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Pharmaceutical composition and novel use of preparation of pharmaceutical composition in preparation of anti-influenza drug

A composition and anti-influenza technology, applied in antiviral agents, pharmaceutical formulations, plant raw materials, etc., can solve the problems of difficult to develop and widely use influenza vaccines, easy to large-scale outbreaks, and fast mutation of influenza viruses.

Active Publication Date: 2014-11-26
ZHANGZHOU PIEN TZE HUANG PHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the influenza virus itself mutates quickly and is prone to large-scale outbreaks, once an outbreak of influenza occurs, it is difficult to develop and widely use corresponding influenza vaccines in time
Although chemical antiviral drugs have definite antiviral activity and a clear mechanism of action, the varieties against influenza are very limited, and as the virus continues to mutate, drug resistance will become more prominent, which also limits its cure to a certain extent. Effect

Method used

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  • Pharmaceutical composition and novel use of preparation of pharmaceutical composition in preparation of anti-influenza drug
  • Pharmaceutical composition and novel use of preparation of pharmaceutical composition in preparation of anti-influenza drug
  • Pharmaceutical composition and novel use of preparation of pharmaceutical composition in preparation of anti-influenza drug

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Experimental program
Comparison scheme
Effect test

Embodiment l

[0135] Embodiment 1: the preparation of tablet

[0136] [Prescription] Honeysuckle 234g; Vitex root 390g; Guanzhong 234g; Sanchaku 234g; Gourd tea 234g; Licorice 234g; Peppermint oil 2ml.

[0137] [Preparation method] Take 1 / 3 of honeysuckle and crush it into fine powder; add 6 times the weight of water to the other 2 / 3 of honeysuckle, warm soak at 85°C for 1 hour, filter to obtain honeysuckle extract; Add water to decoct gourd tea and licorice five flavors twice, add 6 times the weight of water for the first time, decoct for 2 hours, add 4 times the weight of water for the second time, decoct for 1 hour, filter, combine the decoction liquid, and mix with the above The honeysuckle extracts are combined and concentrated into a thick paste; the above-mentioned honeysuckle fine powder, auxiliary materials and binders are added to make granules, boiled and dried, granulated, sprayed with peppermint oil, mixed evenly, and pressed into tablets; wherein the auxiliary materials are S...

Embodiment 2

[0138] Embodiment 2: the preparation of tablet

[0139] [Prescription] Honeysuckle 205g; Vitex root 450g; Guanzhong 300g; Sanchaku 210g; Gourd tea 300g; Licorice 200g; Peppermint oil 1ml.

[0140] [Preparation method] Take 1 / 4 honeysuckle and crush it into fine powder; add 7 times the weight of water to the other 3 / 4 honeysuckle, warm soak at 80°C for 0.5 hours, filter to obtain honeysuckle extract; Gourd tea and licorice five flavors were added to 7 times the weight of water and decocted once, filtered, decocted for 3 hours, combined with the above honeysuckle extract, concentrated into a thick paste; Granules, boiled and dried, granulated, sprayed with peppermint oil, mixed evenly, and pressed into tablets; wherein the auxiliary materials are starch: dextrin: micropowder silica gel = 1.5: 1.5: 0.5, and the binder is starch slurry; the auxiliary materials and adhesive Mixtures are conventional dosage.

Embodiment 3

[0141] Embodiment 3: the preparation of tablet

[0142] [Prescription] Honeysuckle 300g; Vitex root 350g; Guanzhong 220g; Sanchaku 290g; Gourd tea 205g; Licorice 295g; Peppermint oil 4ml

[0143] [Preparation method] Take 1 / 2 honeysuckle, crush it into fine powder; add 5 times the weight of water to the other 1 / 2 honeysuckle, soak at 90°C for 2 hours, filter to get honeysuckle extract; Add water to decoct bitterness, gourd tea and licorice 3 times, add 3 times the weight of water for the first time, decoct for 0.5 hours, add 4 times the weight of water for the second time, decoct for 1.5 hours, and add 5 times the water for the third time , decocted for 2.5 hours, filtered, combined the decoction liquid, combined with the above honeysuckle extract, concentrated salty thick paste; added the above honeysuckle fine powder, auxiliary materials and binders to make granules, boiled and dried, granulated, sprayed peppermint oil, mixed evenly, and pressed into tablets; wherein the au...

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Abstract

The invention belongs to the field of pharmaceutical preparations and particularly relates to a pharmaceutical composition and novel use of a preparation of the pharmaceutical composition in preparation of an anti-influenza drug. The composition has an inhibiting effect on influenza virus A I-induced pneumonia and can be used for remarkably reducing the death rate of living bodies infected by the influenza virus A I. The death protective effects of a medial-dose group and a high-dose group of the composition are stronger than that of a low-dose group. The composition has a good inhibiting effect to parainfluenza virus 3, influenza virus A I, respiratory syncytial virus, rhinovirus 14 and the like. The composition has a remarkable curative effect in resisting influenza, which is verified by virtue of a pharmacodynamic research method, so that the pharmaceutical composition has a scientific basis in the clinical application in resisting influenza.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a new application of a pharmaceutical composition and its preparation in preparing anti-influenza drugs. Background technique [0002] Cold is divided into narrow sense and broad sense. In the narrow sense, it refers to the common cold, also known as acute nasopharyngitis, commonly known as "cold". It is a mild upper respiratory tract (nose and throat) viral infection. The most common disease is mostly self-limiting, but has a high incidence rate, affects a wide range of people, and can cause a variety of complications. Traditional Chinese medicine believes that anemopyretic cold is generally treated according to syndrome differentiation by dispelling wind and relieving the exterior, clearing heat and detoxification, clearing lung and purging fire. [0003] A cold in a broad sense also includes influenza, which is more severe than the common cold. Additiona...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/85A61P31/16
Inventor 罗志毅洪绯庄毅超袁慧君殷婷婷
Owner ZHANGZHOU PIEN TZE HUANG PHARM
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