Method for preparing transparent body mold for elastic monitoring research of thermal damage treatment

Abstract

The invention discloses a method for preparing a transparent body mold for elastic monitoring research of thermal damage treatment. The method comprises the following steps: 1, taking egg white and then putting into a container; 2, feeding acrylamide, glycerinum and ammonium persulfate to a container and evenly mixing the raw materials; 3, adding gelatin to the container and fully stirring the gelatin, adding de-aerated water and fully stirring the de-aerated water, centrifuging and removing impurities, so as to obtain mold-making concentrate; 4 enclosing the mold-making concentrate into a body mold, adding TEMED to the mold-making concentrate and beginning solution polymerization, injecting a graphite glycerin mixed solution into the central position of the body mold when the solution is in semi-solidification, and finally preparing the transparent body mold. The method has the significant effects that the elasticity modulus of the body mold can be accurately controlled, the light transmittance is good, dynamic and real-time observation is conveniently carried out on the damaged region of the body mold, graphite is added to the central region of the transparent body mold to be used as a movement marker, and rebuilding of elastic parameter distribution through movement analysis is facilitated.

Description

technical field [0001] The invention relates to the technical field of medical polymer materials, in particular to a method for making a transparent phantom used for elastic monitoring research of thermal injury treatment. Background technique [0002] Thermal injury treatment includes HIFU treatment, microwave treatment and radiofrequency ablation treatment. It mainly uses its thermal effect and directly acts on the lesion tissue to make it coagulate and necrosis due to thermal damage. It has the advantages of directional, non-invasive, efficient and accurate. As a A new treatment method, people often study it by using human tissue model (phantom), phantom research is used to simulate the changes of human tissue after thermal injury treatment, traditional phantoms used to simulate thermal injury treatment research are Agar, gelatin, etc. Later, some people used polyacrylamide hydrogel as a phantom, but the phantom of polyacrylamide hydrogel has a single composition, which i...

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Problems solved by technology

[0002] Thermal injury treatment includes HIFU treatment, microwave treatment and radiofrequency ablation treatment. It mainly uses its thermal effect and directly acts on the lesion tissue to make it coagulate and necrosis due to thermal damage. It has the advantages of directional, non-invasive, efficient and accurate. As a A new treatment method, people often study it by using human tissue model (phantom), phantom research is used to simulate the changes of human tissue after thermal injury treatment, traditional phantoms used to simulate thermal injury treatment research are Agar, gelatin, etc. Later, some people used polyacrylamide hydrogel as a phantom, but the phantom of polyacrylamide hydrogel has a single composition, which is very different from human tissue. Egg white is added to the glue as a temperature-sensitive indicator, but the transparency of the current phantom is not good. After simulating thermal damage treatment, the thermal damage in the irradiated area of ​​the phantom is difficult to observe with the naked eye, and requires professional equipment (such as ultrasonic imaging). equipment) to detect it, and at the same time, the existing methods for preparing phantoms are not easy to control the elastic modulus of the product, or the control of the elastic modulus is inaccurate, and it cannot accurately simulate human tissue

Therefore, the researchers thought of providing a transparent phantom with excellent light transmission and precise elastic modulus control, so that it can perform dynamic, real-time and intuitive observation of the damaged area of ​​the phantom during the process of simulating thermal injury treatment, and Accurate simulation results are obtained; however, the resulting transparent phantom is not conducive to elastic monitoring, and is not conducive to reconstructing the distribution of elastic parameters (including elastic modulus / strain / displacement, etc.) during elastography through motion analysis

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