Unlock instant, AI-driven research and patent intelligence for your innovation.

A phenyl-2-condensed n 4 -Phenylthiosemicarbazide aryl ruthenium complex and its preparation method and use

A technology of phenylamino and ruthenium complexes, applied in ruthenium organic compounds, compounds containing elements of group 8/9/10/18 of the periodic table, platinum group organic compounds, etc., to achieve active supplementation and enhancement, low cost, Effect of enhancing aroma

Active Publication Date: 2016-08-24
GUANGXI UNIV OF CHINESE MEDICINE
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, dozens of anti-tumor drugs currently used in clinical chemotherapy or adjuvant therapy only have a good curative effect on the treatment of some tumors

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A phenyl-2-condensed n <sup>4</sup> -Phenylthiosemicarbazide aryl ruthenium complex and its preparation method and use
  • A phenyl-2-condensed n <sup>4</sup> -Phenylthiosemicarbazide aryl ruthenium complex and its preparation method and use
  • A phenyl-2-condensed n <sup>4</sup> -Phenylthiosemicarbazide aryl ruthenium complex and its preparation method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The phenyl-2-condensed N of the present invention 4 -Phenylthiosemicarbazide aryl ruthenium complex is an organometallic ruthenium ion pair compound, and its chemical name is trichloro-methylisopropylphenyl ruthenium (II) monochloro-phenyl-2-condensed N 4 -Phenylthiosemicarbazide-methylcymenylruthenium(II);

[0039] Its structural formula is:

[0040]

[0041] Its physical and chemical properties: red crystals, easily soluble in water and organic solvents.

[0042] Trichloro-methylisopropylphenyl ruthenium (II) chloride-chloro-phenyl-2-condensed N of the present invention 4 - the preparation method of phenylthiosemicarbazide-cymene ruthenium (II), its concrete steps are as follows:

[0043] Step 1, 65 parts by weight of ruthenium trichloride hydrate with a ruthenium weight content of 37% and 470 parts by weight of gamma-terpinene with a purity of 95% are dissolved in 1450 parts by weight of dehydrated alcohol, heated to reflux and stirred for 6 hours, static Set ...

Embodiment 2

[0049] The phenyl-2-condensed N of the present invention 4 -Phenylthiosemicarbazide aryl ruthenium complex is an organometallic ruthenium ion pair compound, and its chemical name is trichloro-methylisopropylphenyl ruthenium (II) monochloro-phenyl-2-condensed N 4 -Phenylthiosemicarbazide-methylcymenylruthenium(II);

[0050] Its structural formula is:

[0051]

[0052] Its physical and chemical properties: red crystals, easily soluble in water and organic solvents.

[0053] Trichloro-methylisopropylphenyl ruthenium (II) chloride-chloro-phenyl-2-condensed N of the present invention 4 - the preparation method of phenylthiosemicarbazide-cymene ruthenium (II), its concrete steps are as follows:

[0054] Step 1, 70 parts by weight of ruthenium trichloride hydrate with a ruthenium weight content of 37% and 480 parts by weight of gamma-terpinene with a purity of 95% are dissolved in 1500 parts by weight of dehydrated alcohol, heated under reflux and stirred for 6 hours, static S...

Embodiment 3

[0060] The phenyl-2-condensed N of the present invention 4 -Phenylthiosemicarbazide aryl ruthenium complex is an organometallic ruthenium ion pair compound, and its chemical name is trichloro-methylisopropylphenyl ruthenium (II) monochloro-phenyl-2-condensed N 4 -Phenylthiosemicarbazide-methylcymenylruthenium(II);

[0061] Its structural formula is:

[0062]

[0063] Its physical and chemical properties: red crystals, easily soluble in water and organic solvents.

[0064] Trichloro-methylisopropylphenyl ruthenium (II) chloride-chloro-phenyl-2-condensed N of the present invention 4 - the preparation method of phenylthiosemicarbazide-cymene ruthenium (II), its concrete steps are as follows:

[0065] Step 1, 69 parts by weight of ruthenium trichloride hydrate with a ruthenium weight content of 37% and 478 parts by weight of gamma-terpinene with a purity of 95% are dissolved in 1480 parts by weight of dehydrated alcohol, heated under reflux and stirred for 6 hours, static S...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a phenyl-2-acetal N<4>-phenyl thiosemicarbazide ruthenium aryl complex as well as a preparation method and application thereof. The complex has a structural formula (III) in the specification. The chemical name of the complex is trichloromonomethyl isopropylbenzene ruthenium (II) monochloro-phenyl-2-acetal N<4>-phenyl thiosemicarbazide-methyl isopropylbenzene ruthenium (II). The complex shows good inhibitory activities towards gastric cancer SGC7901 cell lines and liver cancer BEL-7404 cell lines, can be used for preparing medicines for treating cancers, and can be used after being prepared into the forms, such as injections, tablets, pills, capsules, suspending agents or emulsion. The preparation method of the phenyl-2-acetal N<4>-phenyl thiosemicarbazide ruthenium aryl complex is simple, is accessible in raw materials and has the advantage of low cost.

Description

technical field [0001] The invention relates to the field of compound preparation, more specifically a phenyl-2-condensed N 4 -Phenylthiosemicarbazide aryl ruthenium complex and its preparation method and use. Background technique [0002] In 1965, biophysics professors Rosenberg and Van Camp of Michigan State University in the United States found that cisplatin had potential anticancer activity, and then cisplatin entered the attention of many researchers. In the past two decades, metal complex antineoplastic drugs have become the main drugs for the treatment of cancer. However, dozens of anti-tumor drugs currently used in clinical chemotherapy or adjuvant therapy only have a good curative effect on the treatment of some tumors. Therefore, the preparation of new metal complex anti-tumor drugs, which can provide more and better options for the treatment of tumor diseases, has become a current research hotspot. Utility model content [0003] The object of the present inv...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07F15/00A61P35/00
CPCC07F15/0046
Inventor 李培源苏炜霍丽妮陈睿
Owner GUANGXI UNIV OF CHINESE MEDICINE