Method for efficiently preparing low-calcium-content folinic acid
A technology of calcium content and folinic acid, applied in the direction of organic chemistry, etc., can solve problems such as no reported preparation, low folinic acid and the like
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0021] The preparation of embodiment 1 folinic acid
[0022] Add 27L of water into a 50L glass reactor, lower the temperature to below 10°C, add the prepared calcium folinate aqueous solution (900g dissolved in 13.5L of water) and 1.2N hydrochloric acid dropwise into the reactor at the same time, and maintain the pH of the system at 2.7-2.9 , the temperature is 6°C to 10°C, and the dropwise addition is completed in 3.5 hours. Centrifuge and rinse with water (4L) to obtain a wet product.
[0023] Add 9L of deionized water into a 20L glass reactor, cool down to 6°C-10°C, add the above wet product to wash, centrifugal filter, rinse with water (4L), and dry the wet product through fluidized bed for 1 hour before 40°C Vacuum drying for 24 hours yielded 686 g of light yellow powder with a water content of 8.1%. The calcium content tested by atomic absorption method is 0.006%, and the residue on ignition is 0.04%.
Embodiment 2
[0024] The preparation of embodiment 2 folinic acid
[0025] Add 300mL water into a 1L four-necked bottle, cool down to below 6°C, add the prepared calcium folinate aqueous solution (20g dissolved in 600mL water) and 2.4N hydrochloric acid to the reaction flask at the same time, to maintain the pH value of the system at 2.3-2.5, The temperature is 2°C-6°C, and the dropwise addition is completed in 3 hours. Filter and wash the filter cake with water to obtain a wet product. The wet product was beaten at room temperature, rinsed, and vacuum-dried at 20°C for 48 hours to obtain 15.5 g of yellow powder with a water content of 8.8%. The calcium content tested by atomic absorption method is 0.004%, and the residue on ignition is 0.03%.
Embodiment 3
[0026] The preparation of embodiment 3 folinic acid
[0027] Add 700mL water into a 1L four-necked bottle, cool down to below 12°C, add the prepared calcium folinate aqueous solution (20g dissolved in 120mL water) and 0.3N hydrochloric acid to the reaction flask at the same time, to maintain the pH of the system at 3.1-3.3, The temperature is 8°C to 12°C, and the dropwise addition is completed in 2.5 hours. Filter and wash the filter cake with water to obtain a wet product. The wet product was beaten at room temperature, rinsed, and vacuum-dried at 40°C for 24 hours to obtain 14.8 g of light yellow powder with a water content of 7.8%. The atomic absorption method tested the calcium content to be 0.022%, and the ignition residue was 0.09%.
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com