Application of cortex mori fatty oil in preparing diuresis-inducing and blood pressure-reducing drug

A technology of Cortex Morus alba and fatty oil, which is applied in the application field of cortex Morus alba fatty oil in the preparation of diuretic and antihypertensive medicines, can solve the problems of inconvenience and medication for unknown patients, and achieve convenience in use, great clinical significance, and convenience in taking Effect

Inactive Publication Date: 2015-01-28
HENAN UNIV OF CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the problem in the prior art that the material basis of the diuretic and antihypertensive effect of Cortex Morus alba is not clear, which brings a lot of inconvenience to patients, the present invention provides The application of Morus Alba Fatty Oil in the preparation of diuretic and antihypertensive drugs, the diuretic and antihypertensive activity of Morus Alba Fatty Oil components were preliminary pharmacological studies, which laid the foundation for further exploration, and provided a basis for clinical treatment of edema. Disease Expansion Medication Resources

Method used

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  • Application of cortex mori fatty oil in preparing diuresis-inducing and blood pressure-reducing drug
  • Application of cortex mori fatty oil in preparing diuresis-inducing and blood pressure-reducing drug
  • Application of cortex mori fatty oil in preparing diuresis-inducing and blood pressure-reducing drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Materials and instruments used in this embodiment:

[0023] 1. Experimental materials

[0024] 1.1 Animals

[0025] Wistar rat, male, weighing 180~220g, provided by the laboratory animal room of Shandong Lukang Pharmaceutical Co., Ltd. Quality Supervision Center, certificate number: 0014947. Raised in a clean animal laboratory at 18-22°C, free to eat and drink.

[0026] SHR rats, male, 13-16 weeks old, provided by Beijing Weitong Lihua Laboratory Animal Technology Co., Ltd., certificate number: SCXK2012-0001. Raised in a clean animal laboratory at 18-22°C, free to eat and drink.

[0027] 1.2 Drugs and reagents

[0028] Mulberry bark was purchased from the Zhengzhou Traditional Chinese Medicine Market, and was identified as a moraceae plant by Professor Chen Suiqing and Professor Dong Chengming of Henan University of Traditional Chinese Medicine. Morus alba Dry root bark of L.;

[0029] The positive control drug was hydrochlorothiazide (HCTZ), purchased from Shandong Renhetang Ph...

Embodiment 2

[0068] Materials and instruments used in this embodiment:

[0069] 1. Experimental materials

[0070] 1.1 Drugs and reagents

[0071] Mulberry bark was purchased from the Zhengzhou Traditional Chinese Medicine Market, and was identified as a moraceae plant by Professor Chen Suiqing and Professor Dong Chengming of Henan University of Traditional Chinese Medicine. Morus alba Dry root bark of L.

[0072] 1.2 Main instruments

[0073] 90-3 Magnetic Stirrer, Shanghai Zhenjie Experimental Equipment Co., Ltd., ZRD-7080 automatic new blast drying oven, Shanghai Zhicheng Analytical Instrument Manufacturing Co., Ltd., SK6200H ultrasonic cleaner, Shanghai Kedao Ultrasonic Instrument Co., Ltd., standard glass Cable extractor (Shanghai Yuming Instrument Co., Ltd.), AB204-N type 1 / 10,000 electronic balance (Henan Aibot Technology Development Co., Ltd.), Q-250A3 grinder (Ruida International), SB-1000 type rotating Evaporator (Shanghai Ailang Instrument Co., Ltd.).

[0074] In this example, the ...

Embodiment 3

[0076] Materials and instruments used in this embodiment:

[0077] 1. Experimental materials

[0078] 1.1 Drugs and reagents

[0079] Mulberry bark was purchased from the Zhengzhou Traditional Chinese Medicine Market, and was identified as a moraceae plant by Professor Chen Suiqing and Professor Dong Chengming of Henan University of Traditional Chinese Medicine. Morus alba Dry root bark of L.

[0080] 1.2 Main instruments

[0081] 90-3 Magnetic Stirrer, Shanghai Zhenjie Experimental Equipment Co., Ltd., ZRD-7080 automatic new blast drying oven, Shanghai Zhicheng Analytical Instrument Manufacturing Co., Ltd., SK6200H ultrasonic cleaner, Shanghai Kedao Ultrasonic Instrument Co., Ltd., standard glass Cable extractor (Shanghai Yuming Instrument Co., Ltd.), AB204-N type 1 / 10,000 electronic balance (Henan Aibot Technology Development Co., Ltd.), Q-250A3 grinder (Ruida International), SB-1000 type rotating Evaporator (Shanghai Ailang Instrument Co., Ltd.).

[0082] In this example, the ...

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Abstract

The invention discloses an application of cortex mori fatty oil in preparing a diuresis-inducing and blood pressure-reducing drug, and discusses a diuresis-inducing and blood pressure-reducing effect of the cortex mori fatty oil on SHR rat. According to the invention, the influences of the cortex mori fatty oil on urine volume of normal rats are observed by adopting a metabolic cage method of rats; and then the influences of the cortex mori fatty oil on urine volume and systolic blood pressure (SBP) of SHR rats are observed by selecting a spontaneously hypertensive rats (SHR) model and dosing for 7 days in repeated doses. The results show that compared with a control group (CMC-Na group), the cortex mori fatty oil has an obvious diuresis-inducing effect on both the normal rats and the SHR rats (P<0.01) and can significantly reduce systolic pressure of the SHR rats (P<0.01). Compared with the prior art, the invention determines that the cortex mori fatty oil components have the obvious diuresis-inducing and blood pressure-reducing effect, so that the use of the cortex mori fatty oil in preparing the diuresis-inducing and blood pressure-reducing drug is convenient, and the problem that much inconvenience is brought to patients who take the drug, due to unknown material basis of the cortex mori playing the diuresis-inducing and blood pressure-reducing effects, is overcome.

Description

technical field [0001] The invention belongs to the application of natural plants, and in particular relates to the application of Morus alba fat oil in the preparation of diuretic and antihypertensive drugs. Background technique [0002] Clinically commonly used diuretics such as furosemide and hydrochlorothiazide are the most commonly used drugs for human cardiovascular diseases. These drugs can lower blood pressure in hypertensive diseases and improve heart failure function in heart diseases. However, these diuretics also have some side effects, such as systemic electrolyte disturbance, decreased blood volume, metabolic acid or alkalosis, etc. Therefore, searching for new natural plant diuretics has become a hot spot in the study of cardiovascular diseases in recent years. It can not only treat and alleviate cardiovascular diseases, but also reduce the occurrence of side effects on the body. [0003] Cortex Mori (Cortex Mori) is the mulberry plant of the Moraceae plant ...

Claims

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Application Information

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IPC IPC(8): A61K36/605A61P7/10A61P9/12
CPCA61K36/605A61K2236/35A61K2236/51A61K2236/53
Inventor 郑晓珂李玲玲曾梦楠袁培培张娜赫金丽王小兰冯卫生匡海学
Owner HENAN UNIV OF CHINESE MEDICINE
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