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Production method for preparing pharmaceutical gelatin by enzyme process

A production method and an enzymatic preparation technology are applied in the field of enzymatic preparation of medicinal gelatin to achieve the effects of improving the degree of loosening and swelling, increasing yield and increasing efficiency

Active Publication Date: 2015-02-04
HUNAN ER KANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0011] The object of the present invention is to provide a kind of production method of enzymatic method for preparing gelatin, to solve the various problems existing in the above-mentioned existing enzymatic method for preparing gelatin technology, further improve the production efficiency and product quality of gelatin as a whole, make the obtained in the traditional extraction method The product quality of the fourth and fifth pass gelatin can also reach a higher level

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  • Production method for preparing pharmaceutical gelatin by enzyme process

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Embodiment 1

[0037] In this embodiment, 1kg of pigskin (wherein the collagen content is measured to be 256.4g) is used to carry out the process through the pretreatment process of the present invention.

[0038] row processing, including the following steps:

[0039] (1) Skin cutting: use a skin cutting machine to cut the leather into strips, and transfer it to the washing tank with a delivery pump;

[0040] (2) Alkali pretreatment: first add water to the leather, then add liquid alkali, control the concentration of the solution to 1.0%, soak at room temperature for 2 days;

[0041] (3) Separation of skin and water, recovery of liquid caustic soda;

[0042] (4) Wash the leather in the washing tank until the pH value of the solution reaches 7.5;

[0043] (5) Enzymolysis: add neutral protease to the leather aqueous solution with adjusted pH value, o Enzymolysis reaction at C for 5 hours;

[0044] (6) Hydrogen peroxide pretreatment: After adding citric acid to adjust the pH value of the s...

Embodiment 2

[0057] In this embodiment, 1 kg of cowhide (278.2 g of collagen content was measured) was used to carry out the process through the pretreatment process of the present invention.

[0058] row processing, including the following steps:

[0059] (1) Skin cutting: use a skin cutting machine to cut the leather into strips, and transfer it to the washing tank with a delivery pump;

[0060] (2) Alkali pretreatment: first add water to the leather, then add liquid alkali, control the concentration of the solution to 0.6%, soak at room temperature for 5 days;

[0061] (3) Separation of skin and water, recovery of liquid caustic soda;

[0062] (4) Wash the leather in the washing tank until the pH value of the solution reaches 6.5;

[0063] (5) Enzymolysis: Add neutral protease to the leather aqueous solution with adjusted pH value, o Enzymolysis reaction at C for 2 hours;

[0064] (6) Hydrogen peroxide pretreatment: After adding citric acid to adjust the pH value of the solution to ...

Embodiment 3

[0071] In this embodiment, 1 kg of cowhide (278.2 g of collagen content was measured) was used to carry out the process through the pretreatment process of the present invention.

[0072] row processing, including the following steps:

[0073] (1) Skin cutting: use a skin cutting machine to cut the leather into strips, and transfer it to the washing tank with a delivery pump;

[0074] (2) Alkali pretreatment: first add water to the leather, then add liquid alkali, control the concentration of the solution to 0.6%, soak at room temperature for 3 days;

[0075] (3) Separation of skin and water, recovery of liquid caustic soda;

[0076] (4) Wash the leather in the washing tank until the pH value of the solution reaches 7.0;

[0077] (5) Enzymolysis: add neutral protease to the leather aqueous solution with adjusted pH value, o Enzymolysis reaction at C for 3 hours;

[0078] (6) Hydrogen peroxide pretreatment: After adding citric acid to adjust the pH value of the solution to ...

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Abstract

The invention belongs to the field of gelatin preparation, and particularly relates to a production method of a pharmaceutical gelatin by an enzyme process. The gelatin prepared by the method can satisfy the index requirements of gelatins for pharmaceutical capsules. The method basically comprises the following steps: leather pretreatment, enzyme-process gelatin extraction, filtering, ion exchange, membrane concentration, straight plate drying, sterilization, gumming, drying, pulverization, and inspection to obtain the finished product. The leather treatment time is obviously shorter than that of the alkaline process, and the acid and alkali consumptions are greatly reduced; and besides, the yield of the high-quality gelatin obtained by the method is greatly enhanced.

Description

technical field [0001] The invention relates to gelatin preparation technology, in particular to a production method for enzymatically preparing medicinal gelatin. Background technique [0002] The finished product of gelatin is a colorless or light yellow transparent flake or particle, and its main composition is a mixture of 18 kinds of amino acid polypeptide molecules with the same composition and a wide molecular weight distribution. The molecular weight is generally tens of thousands to hundreds of thousands. In addition to water and minerals below 15%, the protein content in gelatin reaches more than 85%, which is an ideal protein source. Gelatin is a type of protein obtained by partial hydrolysis of collagen because of its homology with collagen. Collagen has a rod-shaped triple-helix structure, and when it is partially hydrolyzed to prepare gelatin, this triple-helix structure of collagen is partially separated and broken. The amino acid composition of gelatin is s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09H3/00C09H3/02
Inventor 帅放文王向峰章家伟
Owner HUNAN ER KANG PHARMA
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