Panax japonicus extract and application thereof

A technology of extract and saponin, which is applied in the field of bamboo saponin extract, can solve the problems of no unified and reasonable method for prevention and treatment, and the increase in the diagnosis rate of intestinal injury

Active Publication Date: 2015-02-18
湖北森元药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sustained-release agents and enteric solvents such as diclofenac sodium enteric-coated tablets, which have been clinically introduced in recent years, reduce the toxic side effects of gastric damage, but transfer the damage to the distal small intestine [1-3] ; With the development of capsule endoscopy, the diagnosis

Method used

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  • Panax japonicus extract and application thereof
  • Panax japonicus extract and application thereof
  • Panax japonicus extract and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] experimental animals

[0014] Hubei Provincial Animal Experiment Center provided: 60 healthy male BABL / c mice, weighing about 18-24g, fed with standard formula common feed under natural light cycle, constant temperature and humidity conditions, free to eat and drink.

[0015] Instruments and Reagents

[0016] Inverted fluorescence microscope: Nikon ECLIPSE TE2000-S, Japan; full-wavelength microplate reader: Thermo Electron; gel imaging system (Gel Logic-200): Kodak, USA; high-performance gradient PCR instrument: Whatman Biometra, Germany; multifunctional fluorescence Microplate reader: Swiss Tecan Group; ECL chemiluminescence system: Shanghai Ouxiang Scientific Instrument Co., Ltd.

[0017] Diclofenac: CSPC Ouyi Pharmaceutical Co., Ltd., prepare 0.5 mg / ml with 1% carboxymethyl cellulose before use; bamboo ginsenoside IVa: Chengdu Dikang Technology Pharmaceutical Company, dissolve 0.5 mg / ml with normal saline before use mg / ml, 2mg / ml; FD4: product of Sigma Company in t...

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Abstract

The invention provides a panax japonicus extract, comprising an IVa compound as an active component or a pharmaceutically acceptable salt. The invention also provides a monomeric compound extracted from panax japonicas root and stem. The monomeric compound comprises a panax japonicas extract according to the claim 1, and pharmaceutically acceptable auxiliary material and carrier. The panax japonicas extract is applied to preparation of medicines for treating intestinal mucosal injuries; the intestinal mucosal injuries are intestinal mucosal injuries caused by non-steroidal anti-inflammatory drugs. The result shows that the intestinal mucosal injuries of a medication administration team of the panax japonicas IVa and permeability transition are obviously reduced; and the panax japonicus IVa has therapeutic effect on intestinal mucosal injuries caused by the non-steroidal anti-inflammatory drugs.

Description

technical field [0001] The invention provides a bamboo saponin extract and application thereof, specifically bamboo saponin IVa. Background technique [0002] Non-steroidal anti-inflammatory drugs (NSAIDs) are a class of anti-inflammatory drugs widely used clinically, such as the prevention of cardiovascular and cerebrovascular diseases and the treatment of rheumatic diseases, pain, and sports injuries. Sustained-release agents and enteric solvents such as diclofenac sodium enteric-coated tablets, which have been clinically introduced in recent years, reduce the toxic side effects of gastric damage, but transfer the damage to the distal small intestine [1-3] ; With the development of capsule endoscopy, the diagnosis rate of NSAID-induced intestinal injury has increased significantly, and NSAID intestinal injury, which has been neglected for a long time, has attracted more and more attention [3,4] However, there is no uniform and reasonable method for the prevention and trea...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P1/00
CPCA61K31/704
Inventor 袁丁张长城刘朝奇王婷周志勇顿耀艳赵海霞
Owner 湖北森元药业有限公司
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