A kind of bamboo saponin extract and application thereof

Abstract

The invention provides a panax japonicus extract, comprising an IVa compound as an active component or a pharmaceutically acceptable salt. The invention also provides a monomeric compound extracted from panax japonicas root and stem. The monomeric compound comprises a panax japonicas extract according to the claim 1, and pharmaceutically acceptable auxiliary material and carrier. The panax japonicas extract is applied to preparation of medicines for treating intestinal mucosal injuries; the intestinal mucosal injuries are intestinal mucosal injuries caused by non-steroidal anti-inflammatory drugs. The result shows that the intestinal mucosal injuries of a medication administration team of the panax japonicas IVa and permeability transition are obviously reduced; and the panax japonicus IVa has therapeutic effect on intestinal mucosal injuries caused by the non-steroidal anti-inflammatory drugs.

Description

technical field [0001] The invention provides a bamboo saponin extract and application thereof, specifically bamboo saponin IVa. Background technique [0002] Non-steroidal anti-inflammatory drugs (NSAIDs) are a class of anti-inflammatory drugs widely used clinically, such as the prevention of cardiovascular and cerebrovascular diseases and the treatment of rheumatic diseases, pain, and sports injuries. Sustained-release agents and enteric solvents such as diclofenac sodium enteric-coated tablets, which have been clinically introduced in recent years, reduce the toxic side effects of gastric damage, but transfer the damage to the distal small intestine [1-3] ; With the development of capsule endoscopy, the diagnosis rate of NSAID-induced intestinal injury has increased significantly, and NSAID intestinal injury, which has been neglected for a long time, has attracted more and more attention [3,4] However, there is no uniform and reasonable method for the prevention and trea...

AI Technical Summary

Problems solved by technology

Sustained-release agents and enteric solvents such as diclofenac sodium enteric-coated tablets, which have been clinically introduced in recent years, reduce the toxic side effects of gastric damage, but transfer the damage to the distal small intestine [1-3] ; With the development of capsule endoscopy, the diagnosis rate of NSAID-induced intestinal injury has increased significantly, and NSAID intestinal injury, which has been neglected for a long time, has attracted more and more attention [3,4] However, there is no uniform and reasonable method for the prevention and treatment of this complication that threatens human health.

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