Adriamycin liposome temperature-sensitive gel for tumor local injection

Abstract

The invention discloses adriamycin liposome temperature-sensitive gel and a preparation method thereof. The adriamycin liposome temperature-sensitive gel comprises the following components in parts by weight: 1-3 parts of adriamycin or adriamycin hydrochloride, 10-30 parts of soyabean lecithin, 2-8 parts of cholesterol, 5-20 parts of ammonium sulfate, 10-40 parts of 2-hydroxypropyl trimethyl ammonium chloride chitosan, 40-120 parts of sodium glycerophosphate and 500-1500 parts of menstruum. When the adriamycin liposome temperature-sensitive gel is applied to the tumor local injection, the anti-tumor effect of an adriamycin preparation is improved, the dosing frequency is reduced, and the systemic side effects are reduced; the nature of the temperature-sensitive gel is relatively stable and is unlikely to be affected by the environmental pH and the ionic strength.

Description

(1) Technical field

[0001] The invention relates to the technical field of medicine, in particular to a doxorubicin lipothermic gel for local tumor injection and a preparation method thereof. (2) Background technology

[0002] Due to the lack of selectivity of antineoplastic drugs, especially cytotoxic drugs, when they are administered by conventional routes, they often cause great systemic toxicity, which brings great damage to patients, and even makes many patients unable to bear the systemic toxicity. and was forced to discontinue chemotherapy. However, injection into the tumor site can significantly increase the local drug concentration in the tumor, reduce the systemic toxicity of the anti-tumor drug, and thus obtain a good anti-tumor effect. Due to the cumbersome operation and high technical requirements of local drug administration to tumors, it is not suitable for frequent drug use, so it is required that the injected drug dosage form should have a good sustained-re...

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