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Application of N-acetyl-L-cysteine in preparing drug for treating or preventing porcine virus infection

A virus infection, cysteine ​​technology, applied in the direction of antiviral agents, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems such as the application report of N-acetyl-L-cysteine ​​has not yet been seen. , to achieve the effect of enhancing antioxidant defense function, reducing mortality, and high safety

Active Publication Date: 2015-03-11
HUBEI HAOHUA BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A large number of studies have reported that NAC, as an antioxidant, can regulate the metabolic activity of cells by interfering with the production of free radicals and scavenging the generated free radicals. It has been widely used clinically, but at present, there is no report on the application of N-acetyl-L-cysteine ​​in the prevention and treatment of the above-mentioned porcine viral infectious diseases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A kind of application of N-acetyl-L-cysteine ​​in the preparation treatment or prevention porcine virus infection medicine, its steps are:

[0035] A. Weigh 10g of N-acetyl-L-cysteine, 20mL of absolute ethanol, 30mL of Tween-80, and 100mL of water for injection.

[0036] B. Preparation method: first dissolve N-acetyl-L-cysteine ​​in absolute ethanol, then add Tween-80, and finally add water for injection slowly to make up to 100mL.

[0037] C, obtain a kind of N-acetyl-L-cysteine ​​oral liquid (100mg / mL).

[0038] D. It is used to prevent pig diseases at ordinary times. It can be added to the feed at an additive dose of 10mg / kg body weight and used throughout the feeding cycle;

[0039] E. When used for clinical treatment of pig diseases, the oral liquid can be administered orally according to the dose of 100mg / kg body weight,

[0040] F, or the oral liquid is directly fed according to the dose of 100mg / kg body weight,

[0041] G. Or mix the oral liquid with the diet...

Embodiment 2

[0043] A kind of application of N-acetyl-L-cysteine ​​in the preparation treatment or prevention porcine virus infection medicine, its steps are:

[0044] A. Weigh 5g of N-acetyl-L-cysteine, 20mL of absolute ethanol, 30mL of Tween-80, and 100mL of water for injection.

[0045] B. Preparation method: first dissolve N-acetyl-L-cysteine ​​in absolute ethanol, then add Tween-80, and finally add water for injection slowly to make up to 100mL.

[0046] C, obtain a kind of N-acetyl-L-cysteine ​​oral liquid (50mg / mL).

[0047] D. It is used to prevent pig diseases at ordinary times. It can be added to the feed at an additive dose of 10mg / kg body weight and used throughout the feeding cycle;

[0048] E. When used for clinical treatment of pig diseases, the oral liquid can be administered orally according to the dose of 100mg / kg body weight,

[0049] F, or the oral liquid is directly fed according to the dose of 100mg / kg body weight,

[0050] G. Or mix the oral liquid with the diet a...

Embodiment 3

[0052] A kind of application of N-acetyl-L-cysteine ​​in the preparation treatment or prevention porcine virus infection medicine, its steps are:

[0053] A. Weigh 50 g of N-acetyl-L-cysteine, 15 g of lactose, and 35 g of soluble starch.

[0054] B. Preparation method: Mix and granulate N-acetyl-L-cysteine, lactose and soluble starch, dry and granulate, and then pack.

[0055] C, obtain a kind of N-acetyl-L-cysteine ​​granule (N-acetyl-L-cysteine ​​content is 50%).

[0056] D. It is used to prevent pig diseases at ordinary times. It can be added to the feed at an additive dose of 10mg / kg body weight and used throughout the feeding cycle;

[0057] E. When used for clinical treatment of pig diseases, the granules can be fed directly according to the dose of 100mg / kg body weight,

[0058] F. Or mix the granules with the diet according to the dose of 100mg / kg body weight, add it to the feed for use, add it three times a day in the morning, middle and evening, and use it continuo...

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Abstract

The invention discloses an application of N-acetyl-L-cysteine in preparing a drug for treating or preventing porcine virus infection. The application comprises the steps: A, preparing N-acetyl-L-cysteine, absolute ethyl alcohol, tween-80, lactose, soluble starch and bran into a granule, oral liquid or powder, B, adding the granule, the oral liquid or the powder into feed or drinking water, or C, independently administering N-acetyl-L-cysteine, D, continuously using N-acetyl-L-cysteine during a whole feeding period as preventive addition and long-term usage in the feed, E, feeding the powder and the granule directly for treatment, or F, mixing the powder and the granule with daily ration, adding into the feed in the morning, at noon and in the evening every day, and continuously using the powder and the granule. N-acetyl-L-cysteine has high safety, no toxic or side effects, and antiviral activity, and can effectively prevent and treat the porcine circovirus type 2 and porcine epidemic diarrhea virus infection, reduce a mortality rate of infected pigs, and effectively increase a survival rate and productivity of the pigs.

Description

technical field [0001] The invention belongs to the technical field of porcine virus disease prevention and treatment, and more specifically relates to the application of N-acetyl-L-cysteine ​​in the preparation of medicines for treating or preventing porcine virus infection. Background technique [0002] N-acetyl-L-cysteine ​​(NAC) is a derivative of L-cysteine ​​and a synthetic precursor of reduced glutathione with the molecular formula C 5 h 9 NO 3 S, the molecular weight is 163.2, and its biological activity mainly lies in the sulfur group. After entering the animal body, about 97% of NAC is rapidly absorbed by the small intestine, metabolized by small intestine and liver cells, and combined with protein peptide chains to form a variety of metabolites. [0003] NAC is a thiol compound, which is the precursor of natural L-cysteine ​​and reduced glutathione (GSH), and then plays an important role in the body's antioxidant defense system. For a long time, as a mucolytic...

Claims

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Application Information

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IPC IPC(8): A61K31/198A61P31/20A61P31/12
CPCA61K31/198
Inventor 侯永清吴涛丁斌鹰易丹赵迪
Owner HUBEI HAOHUA BIOTECH
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