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Preparation method of ligusticum wallichii and dalbergia wood dry extract for Kuanxin capsules

A dry extract and soft capsule technology, which is applied in the field of traditional Chinese medicine pharmaceuticals, can solve the problems of difficult to achieve disease treatment effects, high energy consumption, and reduced solubility, so as to achieve the improvement of appearance quality and internal quality, reduce energy consumption, and high process efficiency Effect

Inactive Publication Date: 2015-03-18
上海祥鹤药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the drying method of Rhizoma Chuanxiong and Jiangxiang extract in the patent No. ZL03125289.3 of a drug patent for treating acute and chronic myocardial ischemic diseases is decompression drying. This method has high temperature, long time, and large energy consumption. The production efficiency is low, it is easy to coke, and there are defects that the active ingredients will be destroyed, the solubility will be reduced, and it is difficult to achieve the effect of disease treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Weigh Rhizoma Chuanxiong and Jiangxiang, extract, concentrate, alcohol precipitation, concentrate the alcohol precipitation solution to a specific gravity of 1.0 (80°C thermal measurement), add 3% dextrin of the dry extract, and spray dry to obtain.

Embodiment 2

[0010] Weigh Rhizoma Chuanxiong and Jiangxiang, extract, concentrate, alcohol precipitation, concentrate the alcohol precipitation solution to a specific gravity of 1.2 (80°C thermal measurement), add 8% dextrin of dry extract, spray dry, and obtain.

Embodiment 3

[0012] Weigh Rhizoma Chuanxiong and Jiangxiang, extract, concentrate, alcohol precipitation, concentrate the alcohol precipitation solution to a specific gravity of 1.5 (80°C thermal measurement), add 12% dextrin of dry extract, spray dry, and obtain.

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PUM

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Abstract

The invention discloses a preparation method of ligusticum wallichii and dalbergia wood dry extract for Kuanxin capsules. The preparation process comprises the following steps: weighing a certain amount of ligusticum wallichii and dalbergia wood according to a formula, and carrying out extraction, concentration and alcohol precipitation according to the original process. The preparation process is characterized by further comprising the steps of concentrating the alcohol precipitation solution until the specific gravity is 1.0-1.5, adding 3-12% of dextrin, and carrying out spray drying to obtain the product; and carrying out a hot test under an environment at 80 DEG C when the alcohol precipitation solution is concentrated until the specific gravity is 1.0-1.5. Compared with the original process, the preparation method disclosed by the invention is higher in process efficiency and shorter in time, energy consumption is reduced, effective components are prevented from damages, and the appearance quality and the inherent quality of the product are overall improved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a preparation method of Rhizoma Chuanxiong and Jiangxiang dry extracts in the prescription of Kuanxin Soft Capsules. Background technique [0002] Kuanxin Soft Capsule has the effects of promoting blood circulation, removing blood stasis, promoting qi and relieving pain. It is used to treat angina pectoris of coronary heart disease caused by stagnation of qi and blood stasis. It can reduce the frequency of angina pectoris, improve myocardial blood supply, and restore ischemic myocardium. It has been confirmed by clinical trials that Kuanxin Soft Capsules are significantly superior to similar control products in the treatment of patients with coronary heart disease in terms of the number of angina pectoris attacks, TCM symptoms, nitroglycerin withdrawal rate, and electrocardiogram, and there is an obvious dose-effect relationship. However,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61K9/48A61P9/10
CPCA61K36/236A61K36/48A61K2236/51A61K2236/53
Inventor 李学松袁主邦
Owner 上海祥鹤药业有限公司