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Acetazolamide composition lyophilized tablet and preparation method thereof

A technology of acetazolamide and composition, applied in the field of acetazolamide composition freeze-dried tablets and its preparation, to achieve the effects of improving bioavailability, improving formability, and large dissolution rate

Inactive Publication Date: 2015-03-25
HAINAN WEI KANG PHARMA QIANSHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Starch is the basic excipient of oral solid preparations. It is formed by the polymerization of glucose molecules. It is often used as a binder, diluent and disintegrating agent in tablets. It is cheap and easy to obtain, and is safe for the human body. However, starch is used alone as an excipient There is no report on producing acetazolamide freeze-dried tablets by freeze-drying process

Method used

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  • Acetazolamide composition lyophilized tablet and preparation method thereof
  • Acetazolamide composition lyophilized tablet and preparation method thereof
  • Acetazolamide composition lyophilized tablet and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0028]

[0029]

[0030] A. Weigh 100g of cornstarch, add 900ml of purified water and stir, use a pH regulator to control the pH of the solution at 5-7.5, then heat to 72°C and keep for 120 minutes to make 9% (W / V) cornstarch solution.

[0031] B. Measure 45ml of purified water, boil, add 85g of sucrose, stir, after dissolving, continue heating to 100°C, filter with refined cotton, wash the filter with an appropriate amount of hot distilled water, combine the lotion and filtrate, let cool, add Add appropriate amount of distilled water to make the whole volume into 100mL, stir well to obtain B solution.

[0032] C. Mix the solution obtained in step A with the solution obtained in step B, fully stir for 30 minutes, and then lower the solution to normal temperature to obtain a corn-sucrose solution.

[0033] D. Weigh 250 g of acetazolamide, add it into 1 L of corn-sucrose solution, and stir for 30 minutes.

[0034] E. After measuring the content of acetazolamide in the me...

Embodiment 2

[0037]

[0038] A. Weigh 130g of cornstarch, add 900ml of purified water and stir, use a pH regulator to control the pH of the solution at 5-7.5, then heat to 72°C and keep for 120 minutes to make 13% (W / V) cornstarch solution.

[0039] B. Measure 45ml of purified water, boil, add 85g of sucrose, stir, after dissolving, continue heating to 100°C, filter with refined cotton, wash the filter with an appropriate amount of hot distilled water, combine the lotion and filtrate, let cool, add Add appropriate amount of distilled water to make the whole volume into 100mL, stir well to obtain B solution.

[0040] C. Mix the solution obtained in step A with the solution obtained in step B, fully stir for 30 minutes, and then lower the solution to normal temperature to obtain a corn-sucrose solution.

[0041] D. Weigh 250 grams of acetazolamide (calculated as 1000 tablets), add 1L of corn-sucrose solution, and stir for 30 minutes.

[0042] E. After measuring the content of acetazolam...

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Abstract

The invention provides an acetazolamide composition lyophilized tablet and a preparation method thereof and relates to the technical fields of medicines and medicine production. The acetazolamide composition lyophilized tablet comprises acetazolamide, starch and cane sugar. By taking starch and cane sugar as auxiliary materials, heating process is carried out on common corn starch, so that the bonding and disintegrating effects of starch in the tablet can be improved and the formability of the tablet is improved. The acetazolamide composition lyophilized tablet just needs two auxiliary materials: starch and cane sugar. According to the acetazolamide composition lyophilized tablet, by adopting a lyophilizing process of increasing and decreasing the temperature twice, the formability of the tablet is good due to temperature increase and decrease twice, so that the dissolution rate of the tablet is improved, thereby improving the bioavailability of the tablet. The tablet is used for overcoming the defects of common acetazolamide tablet and reducing the types and use level of auxiliary materials in the acetazolamide tablet, is good in dissolution rate and high in bioavailability and can be used for ensuring the curative effect and safety of clinical medication.

Description

technical field [0001] The invention relates to the technical field of medicine and medicine production, in particular to a freeze-dried tablet of acetazolamide composition and a preparation method thereof. Background technique [0002] Acetazolamide tablets are indicated for the treatment of various types of glaucoma. It is an effective auxiliary drug for lowering intraocular pressure for short-term control of acute attacks of various types of glaucoma. For open-angle (chronic simple) glaucoma, if the intraocular pressure cannot be controlled by drugs, and the treatment with this product can control the intraocular pressure in most cases, it can be used as a short-term preoperative adjuvant drug. In the acute phase of angle-closure glaucoma, after using this product to reduce blood pressure, in principle, an appropriate anti-glaucoma operation should be selected according to the situation of the chamber angle and intraocular pressure tracings. This product is also used for...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/433A61K47/36A61K47/26A61P27/06
Inventor 涂文娟李珠珠饶经纬李彪石金友
Owner HAINAN WEI KANG PHARMA QIANSHAN
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