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Eucommia targeting preparation for treating colon cancer and preparation method thereof

A colon cancer, targeting technology, applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, pill delivery, etc., can solve the problem of limited varieties of traditional Chinese medicine and traditional Chinese medicine compound preparations on the market.

Active Publication Date: 2015-03-25
JIANGXI POZIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nowadays, the research and development of colon-targeted preparations using Western medicines as raw materials is quite common, but the marketed varieties of traditional Chinese medicines and traditional Chinese medicine compound preparations are very limited

Method used

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  • Eucommia targeting preparation for treating colon cancer and preparation method thereof
  • Eucommia targeting preparation for treating colon cancer and preparation method thereof
  • Eucommia targeting preparation for treating colon cancer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1 Effect of Eucommia Composition on Proliferation of Human Colon Cancer Cell SW480

[0031] SW480 was cultured in DMEM medium containing 10%, subcultured after 3 days, and the cells were collected in the logarithmic growth phase, spread into a 96-well plate, dissolved Eucommia composition in DMEM medium, and added to the 96-well plate until The final concentration is 50mg / L, and the same amount of DMEM medium is added to the control group, and 5 duplicate holes are set up in each group. The weight percentage of each group of Eucommia composition is as follows:

[0032] ％ Eucommia phenylpropanoid Eucommia iridoids Eucommia polysaccharide Dosing group 1 100 0 0

[0033] Dosing group 2 0 100 0 Dosing group 3 0 0 100 Dosing group 4 20 20 60 Dosing group 5 40 30 30 Dosing group 6 20 30 40

[0034]After cultivating for 48 hours, adopt the CKK-8 method to detect the proliferation of SW480, meas...

Embodiment 2

[0036] The preparation of embodiment 2 eucommia targeting tablet

[0037]

[0038] Stir and mix the eucommia composition, calcium pectin, chondroitin sulfate, and lactose for 15 minutes; prepare amylose into a 10% solution with water, add it to the mixture for granulation, pass through a 16-mesh sieve, and dry at 40°C for 1 hour , granulated, added micro-powdered silica gel, mixed evenly, and pressed into tablets according to conventional methods to obtain Eucommia Targeted Tablets, weighing 300 mg. The eucommia composition is composed of 40% eucommia phenylpropanoid, 30% eucommia iridoid and 30% eucommia polysaccharide.

Embodiment 3-5

[0040] Except the composition of following table, other is all the same with embodiment 2,

[0041] g Example 3 Example 4 Example 5 Composition of Eucommia 400 400 400

[0042] calcium pectin 150 250 250 Chondroitin Sulfate 100 150 0 Amylose 100 150 150 lactose 2 4 2 Micropowder silica gel 2 4 2

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PUM

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Abstract

The invention belongs to the field of traditional Chinese medicines, and particularly relates to an eucommia targeting preparation for treating colon cancer and a preparation method thereof. The eucommia targeting preparation comprises eucommia composition and auxiliary materials, wherein the eucommia composition comprises, in percentage by weight, 10-80% of eucommia phenylpropanoids, 10-80% of eucommia iridoid and 10-80% of eucommia polysaccharide; the auxiliary materials comprise one or more of pectin, pectic calcium, polyacrylic resin, chitosan, beta-cyclodextrin, lactose, calcium hydrophosphate, glucan, amylose, guar gum, chondroitin sulfate, sodium alginate, talcum powder, aerosil, calcium bicarbonate and magnesium stearate.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to an eucommia targeting preparation for treating colon cancer and a preparation method thereof. Background technique [0002] Colon cancer (carcinoma of colon) is a common malignant tumor of the digestive tract, which can occur in any part of the colon, and the sigmoid colon is the most common. According to the world epidemiological survey, colon cancer has the highest incidence rate in North America, Western Europe, Australia, New Zealand and other places, ranking the top two or three among malignant tumors. In my country, according to the latest research data, the incidence and mortality of colorectal cancer are increasing year by year, especially in some big cities, the incidence of colorectal cancer is rising rapidly, such as Shanghai, the incidence of colorectal cancer has increased from earlier The incidence rate of lung cancer has risen from the fifth...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P35/00A61P1/00
CPCA61K9/0053A61K9/28A61K31/715A61K36/46A61K47/02A61K47/36A61K47/40A61K2300/00
Inventor 肖军平吴永忠杨伟庆陈金德李小锋
Owner JIANGXI POZIN PHARMA
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