Method for preparing 3-nitropropionic acid

A technology of nitropropionic acid and ethyl nitropropionate, applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., can solve the problems of high production cost and expensive reagents
CN104447346AInactive Publication Date: 2015-03-25QUFU DELU BIOTECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
QUFU DELU BIOTECH
Publication Date
2015-03-25
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for preparing 3-nitropropionic acid. Acrylic acid serves as a raw material, and the 3-nitropropionic acid is prepared by the following four steps: performing olefin addition, performing esterification, carrying out an SN2 reaction and hydrolyzing. Compared with the other methods, the method has the advantages of readily available raw materials, low price, simplicity in operation, mild and controllable conditions, high yield and the like.
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Description

technical field

[0001] The invention belongs to the technical field of compound synthesis, and in particular relates to a preparation method of 3-nitro propionic acid. technical background

[0002] The structural formula of 3-nitropropionic acid is as formula 1,

[0003]

[0004] 1

[0005] 3-Nitropropionic acid is a very useful organic chemical intermediate, which can be used in the synthesis of β-amino acids.

[0006] In addition, it has recently been found that 3-nitropropionic acid has a protective effect on dopaminergic nerves, thereby achieving the effect of preventing Parkinson's disease. It is mainly related to reducing the generation of malondialdehyde, stimulating the synthesis of reduced glutathione, and protecting dopamine neurons. In addition, 3-nitropropionic acid preconditioning can induce cerebral ischemic tolerance and exert a protective effect on focal ischemia-reperfusion injury. It may be related to reducing the permeability of the blood-brain bar...

Claims

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