Automatic bone marrow sample processing device, and automated analyzing and radiograph reading method thereof

Abstract

The invention relates to an automatic bone marrow sample processing device, and an automatic analyzing and radiograph reading method thereof. The device combines automatic staining technology, sample quality automatic detection technology, encrpytion technology, microscopical technology and image processing technology, and can realize the all-around automation of staining, scanning and radiograph reading. The automatic radiograph reading method comprises the steps of firstly, performing low-power lens complete sample scanning and splicing, so as to obtain a low-power lens complete sample panoramic image, then inputting an interested characteristic parameter set, and finally performing high-power lens interested region scanning and splicing, so as to obtain a high-power lens interested region panoramic image set. Compared with the traditional bone marrow sample processing and radiograph reading method, the automatic analyzing and radiograph reading method has the advantages that the problem that the complete marrow sample quality cannot be checked by doctors on the whole is solved, and the radiograph reading speed and accuracy of doctors are improved. The low-power lens panoramic image and the high-power lens panoramic image set obtained can serve as an objective base and experimental data for clinical diagnosis and provide a necessary support for the development of myelopathy diagnostics, and are huge in social benefit.

Description

technical field [0001] The invention relates to an automatic bone marrow sample processing device and its automatic analysis and film reading method, belonging to the technical field of biomedical detection and analysis instruments and methods, in particular to a human bone marrow sample processing device and automatic analysis and film reading method. Background technique [0002] Blood cell morphology test is an important item in the basic diagnosis of blood diseases and routine hematology tests, and is the most basic, convenient and practical test method. Blood cell morphology examination mainly includes two parts: bone marrow and peripheral blood cell morphology examination. The quality of blood cell morphology inspection is the key to the prevention, diagnosis, differential diagnosis and prognosis of many diseases, especially blood diseases. However, in actual clinical diagnosis, there is often a lack of unified standard testing methods and testing conditions, and due ...

AI Technical Summary

Problems solved by technology

[0003] The traditional staining and sample inspection of bone marrow samples requires staff to do it manually. During the staining process, the doctor needs to estimate the time by himself. After the sample is stained, the staff also needs to perform sample quality inspection according to subjective standards, resulting in low efficiency. , the accuracy rate is not high

According to the standard operating requirements of clinical diagnosis, the examination doctor often needs to complete the morphological analysis of more than 500 nucleated cells in the diagnosis of bone marrow cells. Therefore, it is necessary for the examination doctor to perform manual operations for a long time, which will easily lead to low diagnostic efficiency and waste of human resources.

In addition, the traditional bone marrow sample reading needs to be done manually. First, the doctor has to select the area of ​​interest under the low-power lens, and then move the platform to the area for high-power scanning. If there are too many areas of interest, the doctor will perform multiple scans. Switching between high and low magnification mirrors greatly affects the efficiency, and after multiple area selections, doctors cannot concentrate on the area of ​​interest as a whole, which will reduce the diagnostic accuracy

The patent of authorized notification number CN 1296699C discloses a microscopic multi-spectral bone marrow and peripheral blood cell automatic analyzer and a method for analyzing bone marrow and peripheral blood cells, but the process of spectral analysis and image processing is too complicated and time-consuming, which is not suitable for clinical application, and The automatic analyzer only realizes the automation of scanning and image analysis and processing, but does not realize the all-round automation of auxiliary scanning such as sample staining, sample quality inspection, and image processing.

In addition, the patent CN 101407759A "blood cell analyzer and analysis method" and the patent CN 103604737A "an automatic blood cell identification device and working method" are both based on the automation of sample scanning, and both use manual dyeing and manual quality inspection. It completely breaks through the traditional idea of ​​blood cell sample processing. Therefore, clinical laboratory doctors urgently need a fully automatic device that can automatically stain, automatically detect sample quality, automatically analyze, and read the morphology of bone marrow cells to assist clinicians in completing the diagnosis of bone marrow cell samples. and retain objective diagnostic data

Images