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Method for comprehensive utilization of lycoris resource

A technology of Lycoris and volume, applied in the field of separation of natural products, can solve the problems of difficulty in removing impurities similar to alkaloids, unsuitable for high-quality requirements, etc., and achieve the effects of shortening processing time, reducing operation steps, and reducing production costs

Active Publication Date: 2015-04-01
徐州天骋智能科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is difficult to remove impurities similar to alkaloids by adopting the traditional separation process, which does not meet the current high-quality requirements of galantamine in various countries in the world. The utilization rate of Lycoris bulbs is only 1%, and the waste generated by extracting galantamine reaches 99%. It is not directly discarded, so the production process of separating and purifying galantamine with high efficiency, high purity and low cost has far-reaching significance. At the same time, making full use of Lycoris waste is also conducive to the long-term development of Lycoris resource development

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Grind and dry 100 kg of Lycoris bulbs, add 500 L of acetone aqueous solution, extract by cold soaking at room temperature three times, each extraction is 1.5 hours, filter once with a ceramic membrane to obtain 400 L of filtrate, and wash the residue of Lycoris with 400 kg of 20% acrylic acid solution to obtain Aqueous solution of starch acrylic acid; Concentrate the ethanol solution of Lycoris total alkali to dry matter under reduced pressure to obtain 1.5kg of Lycoris total alkali; Add 0.001mol / L hydrochloric acid solution 300mL to the dry matter of Lycoris total alkali to dissolve, and make the solution pH Less than 6.0, 8000rpm was centrifuged for 5min to remove insoluble matter to obtain a supernatant; the supernatant was placed on a 732-type cation exchange resin column (Tianjin Bohong Resin Technology Co., Ltd.), washed to neutrality with three times the volume of water, and then washed with four Double the volume of 1mol / L sodium carbonate solution for elution, c...

Embodiment 2

[0040] Grind and dry 200 kg of Lycoris bulbs, add 900 L of acetone aqueous solution, and extract by cold soaking at room temperature three times, each extraction is 1.5 hours, filter once with a ceramic membrane to obtain 800 L of filtrate, and wash the Lycoris residue with 700 kg of 20% acrylic acid aqueous solution to obtain Starch acrylic acid aqueous solution; Concentrate the ethanol solution of Lycoris total alkali to dryness under reduced pressure to obtain 3.12kg of Lycoris total alkali; Add 0.001mol / L hydrochloric acid solution 700mL to the dry matter of Lycoris total alkali to dissolve, and make the pH of the solution Less than 6.0, 8000rpm was centrifuged for 5min to remove insoluble matter to obtain a supernatant; the supernatant was placed on a 732-type cation exchange resin column (Tianjin Bohong Resin Technology Co., Ltd.), washed to neutrality with three times the volume of water, and then washed with four Double the volume of 1mol / L sodium carbonate solution for...

Embodiment 3

[0042] Grind and dry 400 kg of Lycoris bulbs, add 1200L of acetone aqueous solution, extract by cold soaking at room temperature three times, each extraction is 1.5 hours, and filter once with a ceramic membrane to obtain 1100L of filtrate, and the residue of Lycoris is rinsed with 1200kg of 20% acrylic acid aqueous solution to obtain Aqueous starch acrylic acid solution; Concentrate the ethanol solution of Lycoris total alkali to dryness under reduced pressure to obtain 6.25kg of Lycoris total alkali; Add 1.2L of 0.001mol / L hydrochloric acid solution to the dried product of Lycoris total alkali Value is less than 6.0, and 8000rpm centrifuges 5min to remove insoluble matter, obtains supernatant; The 732 type cation exchange resin columns (Tianjin Bohong Resin Technology Co., Ltd.) on the supernatant are washed to neutrality with three times the volume of water, and then used Four times the volume of 1mol / L sodium carbonate solution was used for elution, and the eluate was colle...

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PUM

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Abstract

The invention provides a method for preparing galanthamine and a water retaining gel from lycoris. The method comprises the following steps: refluxing dried lycoris by using a 70-90% alcoholic solution to extract lycorine, performing column separation to obtain galanthamine, washing lycoris residues by using an acrylic acid solution, and compounding with a catalyst to obtain the water retaining gel. According to the method, the starch in the lycoris is fully used for preparing water retaining gel, and the pollution of lycoris wastes to the environment is avoided. An acrylic acid aqueous solution is directly used for washing to dissolve out starch, so that operation steps are reduced, the time for treating the lycoris wastes is shortened, and the production cost of lycorine is reduced.

Description

technical field [0001] The invention belongs to the technical field of separation of natural products, and mainly relates to the high-efficiency utilization of lycoris resources, in particular to a method for extracting galantamine from lycoris and using its starch to prepare water-retaining gel. Background technique [0002] With the intensification of the aging society, Alzheimer's disease (AD), commonly known as senile dementia, is causing an increasing burden of disease, mainly manifested in the continuous decline of memory function and cognitive ability, accompanied by various behavioral disorders and neuropsychiatric disorders. Symptoms, changes in behavior and personality, loss of self-care ability, and finally death, it is the fourth largest health killer of human beings after cardiovascular disease, cancer and stroke. According to the latest data released by Alzheimer's Disease International Federation, there were 36 million Alzheimer's patients in the world in 2010...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D491/107C08F251/00C08F220/06
CPCC07D491/107C08F251/00C08F220/06
Inventor 唐忠海
Owner 徐州天骋智能科技有限公司
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