Cimetidine composition chewable tablets and preparation method thereof

A technology of cimetidine and composition, applied in the field of cimetidine composition chewable tablet and its preparation, to achieve the effect of improving molding, improving quality and bioavailability, and convenient operation

Inactive Publication Date: 2015-04-08
HAINAN WEI KANG PHARMA QIANSHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Starch is formed by the polymerization of glucose molecules. It is the basic auxiliary material of oral solid preparations. It is often used as a binder, diluent and disintegrating agent in chewable tablets. The starch is extracted from natural substances such as corn and cassava. It is safe, reliable, It is cheap and easy to obtain, but there is no report on the use of starch alone as an auxiliary material for the production of chewable tablets

Method used

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  • Cimetidine composition chewable tablets and preparation method thereof
  • Cimetidine composition chewable tablets and preparation method thereof
  • Cimetidine composition chewable tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Prescription: 1000 tablets

[0029]

[0030] A. Weigh 100g of cornstarch, add 900ml of purified water and stir, use a pH regulator to control the pH of the solution at 6.5, then heat to 72°C and keep for 120 minutes to make about 10% (W / V) Gelatinized cornstarch solution.

[0031] B. Measure 45ml of purified water, boil, add 85g of sucrose, stir, after dissolving, continue heating to 100°C, filter with refined cotton, wash the filter with an appropriate amount of hot distilled water, combine the lotion and filtrate, let cool, add Add appropriate amount of distilled water to make the whole volume into 100mL, stir well to obtain B solution.

[0032] C. Mix the medicinal solution obtained in step A with the solution obtained in step B, stir thoroughly for 30 minutes, and then lower the medicinal solution to normal temperature to obtain a gelatinized corn-sucrose system medicinal solution.

[0033] D, take by weighing 100g of cimetidine (calculated as 1000 tablets), ad...

Embodiment 2

[0038] Prescription: 1000 tablets

[0039]

[0040] A. Weigh 150g of cornstarch, add 900ml of purified water and stir, use a pH regulator to control the pH of the solution at 6.5, then heat to 72°C and keep for 120 minutes to make about 5-15% (W / V ) of gelatinized cornstarch solution.

[0041] B. Measure 45ml of purified water, boil, add 85g of sucrose, stir, after dissolving, continue heating to 100°C, filter with refined cotton, wash the filter with an appropriate amount of hot distilled water, combine the lotion and filtrate, let cool, add Add appropriate amount of distilled water to make the whole volume into 100mL, stir well to obtain B solution.

[0042] C. Mix the medicinal solution obtained in step A with the solution obtained in step B, stir thoroughly for 30 minutes, and then lower the medicinal solution to normal temperature to obtain a gelatinized corn-sucrose system medicinal solution.

[0043] D, take by weighing 100g of cimetidine (calculated as 1000 tablet...

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PUM

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Abstract

The invention provides cimetidine composition chewable tablets and a preparation method thereof and relates to the technical field of medicines and medical production. The cimetidine composition chewable tablets comprise cimetidine, starch and cane sugar, the defects of common chewable tablets are overcome by virtue of the tablets disclosed by the invention, the types and amount of auxiliary materials in the cimetidine chewable tablets are reduced, and the pharmaceutical preparation is excellent in performance, high in bioavailability, high in stability and high in patient acceptance, does not have a sense of gravel and has important clinical application value.

Description

technical field [0001] The invention relates to the technical field of medicine and medicine production, in particular to a cimetidine composition chewable tablet and a preparation method thereof. Background technique [0002] Tablets are stable in quality and easy to take, and are the most basic and commonly used preparation form. However, for children, the elderly, and patients with dysphagia, ordinary tablets are often difficult to take, and long-term medication may even lead to psychological drug resistance. Chewable tablets can make up for this deficiency. Chewable tablets are a type of tablet that can be chewed and swallowed in the oral cavity. They are generally the same size as ordinary tablets, and can be made into special-shaped tablets of different shapes according to needs. The tablet is easy to swallow after being chewed, and the surface area of ​​the tablet increases, which can promote the dissolution and absorption of the drug in the body. For drugs that are...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4164A61K47/36A61K47/26A61P1/04
Inventor 吴函峰汪宁卿李珠珠饶经纬李彪
Owner HAINAN WEI KANG PHARMA QIANSHAN
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