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Acarbose capsule pharmaceutical composition

A technology of acarbose and capsules, which is applied in the field of medicine and can solve problems such as inconvenient taking, inability to guarantee tablet weight qualification, powder spraying, etc.

Active Publication Date: 2015-04-22
HANGZHOU ZHUYANGXIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Disadvantages of this method: acarbose has poor fluidity, even if lubricant is added, its fluidity cannot be improved well, and the main drug and auxiliary materials are mixed and pressed into tablets. The raw material of acarbose is relatively light, and the auxiliary materials After mixing directly, and then compressing the tablets, there will be large differences in the tablets, and even unqualified phenomena, and powder spraying will occur during the tableting process, which cannot guarantee the eligibility of the tablet weight
It is believed that the invention overcomes the disadvantages of inconvenient administration of existing tablets and capsules, and provides an easier-to-administer acarbose preparation that disintegrates rapidly in the oral cavity and does not require water

Method used

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  • Acarbose capsule pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0099] Embodiment 1: Preparation of acarbose capsules

[0100] formula:

[0101] Acarbose

50mg

microcrystalline cellulose

20mg

corn starch

90mg

Modified pregelatinized starch

40mg

silica

1mg

Magnesium stearate

1.5mg

[0102] Preparation method:

[0103] (1) Mix acarbose and the microcrystalline cellulose of the prescribed amount evenly, and spray concentration>98% ethanol (the weight ratio of acarbose to the ethanol is 50:4) into the mixed powder under high-speed mixing state. ), the resulting mixture is pre-compressed into tablets with an extruder, and then the tablets are broken into granules, dried to remove ethanol, and then the granules are pulverized into fine powders crossing 80 mesh sieves;

[0104] (2) Mix other diluents that have been pulverized and crossed 80 mesh sieves with the mixed powder obtained in step (1) in advance;

[0105] (3) mixing the glidant and lubricant with the mixed p...

Embodiment 2

[0108] Embodiment 2: preparation of acarbose capsules

[0109] formula:

[0110] Acarbose

50mg

microcrystalline cellulose

20mg

Cassava starch

87.5mg

Modified pregelatinized starch

40mg

silica

1mg

Magnesium stearate

1.5mg

[0111] Preparation method:

[0112] (1) Mix acarbose and the microcrystalline cellulose of the prescribed amount evenly, and spray concentration>98% ethanol (the weight ratio of acarbose to the ethanol is 50:3) into the mixed powder under high-speed mixing state ), the resulting mixture is pre-compressed into tablets with an extruder, and then the tablets are broken into granules, dried to remove ethanol, and then the granules are pulverized into fine powders crossing 80 mesh sieves;

[0113] (2) Mix other diluents that have been pulverized and crossed 80 mesh sieves with the mixed powder obtained in step (1) in advance;

[0114] (3) mixing the glidant and lubricant with the mi...

Embodiment 3

[0117] Embodiment 3: Preparation of acarbose capsules

[0118] formula:

[0119] Acarbose

50mg

microcrystalline cellulose

15mg

Potato starch

95mg

Modified pregelatinized starch

45mg

silica

0.5mg

Magnesium stearate

1.2mg

[0120] Preparation method:

[0121] (1) Mix acarbose and the microcrystalline cellulose of the prescribed amount evenly, and spray ethanol with a concentration>98% into the mixed powder under high-speed mixing state (the weight ratio of acarbose and the ethanol is 50:2 ), the resulting mixture is pre-compressed into tablets with an extruder, and then the tablets are broken into granules, dried to remove ethanol, and then the granules are pulverized into fine powders crossing 80 mesh sieves;

[0122] (2) Mix other diluents that have been pulverized and crossed 80 mesh sieves with the mixed powder obtained in step (1) in advance;

[0123] (3) mixing the glidant and lubricant with ...

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Abstract

The invention relates to an acarbose capsule pharmaceutical composition. Concretely, the acarbose capsule pharmaceutical composition comprises a capsule shell and powdery or granular filler wrapped in the capsule shell, wherein the capsule shell is made by taking gelatin, hydroxypropyl methyl cellulose, algal polysaccharides, pectin or carboxymethyl cellulose as a main component, the filler comprises an active substance, a diluent, a lubricating agent and a glidant, and the active substance is acarbose. The acarbose capsule pharmaceutical composition has excellent pharmaceutical property.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a pharmaceutical composition, in particular to a pharmaceutical preparation in the form of a hard capsule, in particular to an acarbose capsule pharmaceutical composition. The invention also relates to a process for their preparation. Background technique [0002] Diabetes Mellitus (DM) is a group of metabolic diseases characterized by chronic increase in blood glucose (referred to as blood sugar) level, which is caused by defects in insulin secretion and / or action. Long-term carbohydrate, fat, and protein metabolic disorders can cause multi-system damage, leading to chronic progressive lesions, functional decline, and failure of tissues and organs such as eyes, kidneys, nerves, heart, and blood vessels. Severe metabolic disorders can occur in severe conditions or stress, such as diabetic ketoacidosis (DKA), hyperglycemia and hyperosmolar state, etc. The disease reduces the quali...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/7036A61K47/42A61K47/38A61K47/36A61P3/10
Inventor 李阅东唐建飞沈如杰何海珍马雯霞姚成娥张群赵福斌张婧
Owner HANGZHOU ZHUYANGXIN PHARMA
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