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Traditional Chinese medicine preparation for preventing and treating hepatic fibrosis, soft capsule for preventing and treating hepatic fibrosis and preparing process of traditional Chinese medicine preparation and soft capsule

A technology for liver fibrosis and traditional Chinese medicine preparations, applied in capsule delivery, medical preparations containing active ingredients, digestive system, etc., can solve the problems of less research on compound prescriptions, insufficient effect, and no breakthrough progress.

Inactive Publication Date: 2015-04-22
广东广发制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The formation and development of liver fibrosis is an extremely complicated process. In the past 10 years, the research on the anti-hepatic fibrosis treatment of traditional Chinese medicine has made some progress, but there is no breakthrough progress, and there are few studies under the guidance of the theory of traditional Chinese medicine. There are many researches on ingredients, but few researches on compound prescriptions, and the effect is not good enough

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] A traditional Chinese medicine preparation for preventing and treating liver fibrosis, which comprises the following medicinal materials in parts by weight: 500 parts of Panax notoginseng, 300 parts of Radix Astragali, 100 parts of Danshen and 300 parts of Scrophulariae.

[0065] A soft capsule for preventing and treating liver fibrosis, the content of the soft capsule is composed of effective dry cream powder, soybean oil, and beeswax of the extracts of the above-mentioned traditional Chinese medicine preparation; the weight ratio of the effective dry cream powder to soybean oil is 3 : 7, the addition ratio of beeswax is 4% of soybean oil; the capsule shell is made of 0.95 part of gelatin, 0.5 part of glycerin and 0.8 part of water by weight.

[0066] A preparation process of soft capsules for preventing and treating liver fibrosis, comprising the following steps:

[0067] (1) Preparation of dry paste powder of traditional Chinese medicine preparations:

[0068] A1, t...

Embodiment 2

[0080] The difference between this example and Example 1 is: a traditional Chinese medicine preparation for preventing and treating liver fibrosis in this example, which includes the following medicinal materials in parts by weight: 650 parts of Panax notoginseng, 280 parts of Radix Astragali, 120 parts of Salvia miltiorrhiza, Scrophulariaceae 250 copies.

[0081] A soft capsule for preventing and treating liver fibrosis, the content of the soft capsule is composed of effective dry cream powder, soybean oil and beeswax of the extracts of the above-mentioned traditional Chinese medicine preparation; the weight ratio of the effective dry cream powder to soybean oil is 4 : 6, the addition ratio of beeswax is 4.5% of soybean oil; the capsule shell is made of 1 part of gelatin, 0.35 part of glycerin and 0.95 part of water in parts by weight.

[0082] A preparation process of soft capsules for preventing and treating liver fibrosis, comprising the following steps:

[0083] (1) Prep...

Embodiment 3

[0095] The difference between this example and Example 1 is: a Chinese medicine preparation for preventing and treating liver fibrosis in this example, which includes the following medicinal materials in parts by weight: 900 parts of Panax notoginseng, 180 parts of Astragalus membranaceus, 220 parts of Danshen, and Scrophulariaceae 220 copies.

[0096] A soft capsule for preventing and treating liver fibrosis, the content of the soft capsule is composed of effective dry cream powder, soybean oil and beeswax of the extracts of the above-mentioned traditional Chinese medicine preparation; the weight ratio of the effective dry cream powder to soybean oil is 5 : 7, the addition ratio of beeswax is 5% of soybean oil; the capsule shell is made of 0.98 part of gelatin, 0.45 part of glycerin and 0.9 part of water in parts by weight.

[0097] A preparation process of soft capsules for preventing and treating liver fibrosis, comprising the following steps:

[0098] (1) Preparation of t...

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PUM

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Abstract

The invention relates to the technical field of traditional Chinese medicine manufacturing, in particular to a traditional Chinese medicine preparation for preventing and treating hepatic fibrosis, a soft capsule for preventing and treating the hepatic fibrosis and a preparing process of the traditional Chinese medicine preparation and the soft capsule. The traditional Chinese medicine preparation comprises, by weight, 500-1000 parts of seudo-ginseng, 150-350 parts of astragalus membranaceus, 100-300 parts of roots of red-rooted salvia and 150-350 parts of radix scrophulariae. According to the traditional Chinese medicine preparation, multiple Chinese herbal compound components are adopted, the traditional Chinese medicine preparation has obvious advantages in preventing and treating the hepatic fibrosis through the multi-component, multi-link, multi-level and multi-target pharmacological effects of the Chinese herbal compound, and the soft capsule has the advantages of being precise in content, good in stability, good in dissolution, high in absorption speed, small in side effect, convenient to carry, safe and convenient to take, small in dose, high in bioavailability, quick in curative effect, good in effect and the like.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine pharmacy, in particular to a traditional Chinese medicine preparation for preventing and treating liver fibrosis, a soft capsule and a preparation process thereof. Background technique [0002] Liver fibrosis refers to the abnormal proliferation of connective tissue in the liver caused by various pathogenic factors, leading to the pathological process of excessive precipitation of diffuse extracellular matrix in the liver. It is not an independent disease, and many chronic liver diseases can cause liver fibrosis. change. Liver fibrosis caused by accumulation of extracellular matrix (ECM) in the process of chronic liver injury can be reversed by effective treatment, but once cirrhosis is formed, it is difficult to reverse. Effective treatment of liver fibrosis mainly includes etiological treatment targeting the primary disease, anti-inflammatory treatment, inhibition of ECM ge...

Claims

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Application Information

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IPC IPC(8): A61K36/808A61K9/48A61P1/16
Inventor 夏羽李渡春钟耀清黄斌安天祥
Owner 广东广发制药有限公司
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