A kind of synthetic method of 3-amino-4-fluorophenylboronic acid

A technology of fluorophenylboronic acid and synthesis method, which is applied in the field of preparation of 3-amino-4-fluorophenylboronic acid, can solve problems such as expensiveness and difficulty in obtaining, and achieves the effects of low cost, simple and easy operation and high yield.

Active Publication Date: 2016-08-24
DALIAN NETCHEM CHIRAL TECH
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is theoretically possible to prepare 3-amino-4-fluorophenylboronic acid from 3-amino-4-fluorophenylboronic acid pinacol ester depinacol, but in this way, there is one more step reaction, and another disadvantage of this route is PdCl 2 (dppf) expensive, not readily available

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The first step of bromination: the raw materials o-fluoronitrobenzene (367g, 2.6mol) and concentrated sulfuric acid (3057g) were stirred evenly, and N-bromosuccinimide (463g, 2.6mol) was added in batches. warm up to 70 o C reaction. The gas-phase central control reaction is completed. The reaction solution was cooled to room temperature, then poured into ice, and the product 2-fluoro-5-bromonitrobenzene was extracted with 200 ml of ethyl acetate, and evaporated to dryness to obtain a brown solid crude product. The crude product was recrystallized with petroleum ether, the GC was 98%, and the pure product was dried to obtain 198.7g, with a yield of 35.0%;

[0022] The second step reduction: mix 98% 2-fluoro-5-bromonitrobenzene (211g, 0.96mol) and iron powder (212g, 3.8mol), add 1200ml ethanol, drop glacial acetic acid (456g, 7.6 mol). Control the reaction solution with an oil bath for 60 o C reaction, take the reaction liquid and use the gas phase control reaction t...

Embodiment 2

[0025] The first step of bromination: the raw materials o-fluoronitrobenzene (367g, 2.6mol) and concentrated sulfuric acid (2600g) were stirred evenly, and N-bromosuccinimide (463g, 2.6mol) was added in batches. warm up to 65 o C reaction. The gas-phase central control reaction is completed. The reaction solution was cooled to room temperature, then poured into ice, and the product 2-fluoro-5-bromonitrobenzene was extracted with 200 ml of ethyl acetate, and evaporated to dryness to obtain a brown solid crude product. The crude product was recrystallized with petroleum ether, the GC was 98%, and the pure product was dried to obtain 227.1g, with a yield of 40.0%;

[0026] In the second step, 98% 2-fluoro-5-bromonitrobenzene (211g, 0.96mol) and iron powder (163g, 2.9mol) were mixed, 1200ml of ethanol was added, and glacial acetic acid (351g, 5.8mol) was added dropwise at room temperature. Control the reaction solution with an oil bath for 65 o C reaction, gas phase control re...

Embodiment 3

[0029] The first step of bromination: the raw materials o-fluoronitrobenzene (367g, 2.6mol) and concentrated sulfuric acid (2600g) were stirred evenly, and N-bromosuccinimide (535g, 3.0mol) was added in batches. warm up to 75 o C reaction. The gas-phase central control reaction is completed. The reaction solution was cooled to room temperature, then poured into ice, and the product 2-fluoro-5-bromonitrobenzene was extracted with 200 ml of ethyl acetate, and evaporated to dryness to obtain a brown solid crude product. The crude product was recrystallized with petroleum ether, the GC was 98%, and the pure product was dried to obtain 215.7g, with a yield of 38.0%;

[0030] In the second step, 98% 2-fluoro-5-bromonitrobenzene (211g, 0.96mol) and iron powder (134.4g, 2.4mol) were mixed, 1200ml of ethanol was added, and glacial acetic acid (290.4g, 4.8mol) was added dropwise at room temperature ). Control the reaction solution with an oil bath for 55 oC reaction, gas phase cont...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a synthetic method for 3-amino-4-fluorophenylboronic acid. The method includes the steps of conducting bromination on o-fluoronitrobenzene, conducting reduction to generate 5-bromo-2-fluoroanil, making 5-bromo-2-fluoroanil and tetrahydroxydiboron react in a coupled mode to generate the product, namely, 3-amino-4-fluorophenylboronic acid. According to the method, raw materials can be easily obtained, and operation is easy and convenient. The method is an appropriate route for preparing 3-amino-4-fluorophenylboronic acid.

Description

technical field [0001] The invention relates to a preparation method of 3-amino-4-fluorophenylboronic acid. Background technique [0002] In the prior art, the synthesis method of 3-amino-4-fluorophenylboronic acid is to first nitrate p-fluorophenylboronic acid to generate 4-fluoro-3-nitrophenylboronic acid, and then use palladium carbon to catalyze hydrogenation reduction to generate 3-amino- 4-fluorophenylboronic acid (Ref: CN103626791). The problem with this synthetic route is that the nitration of p-fluorophenylboronic acid is difficult to control and the yield is unstable. The 3-amino-4-fluorophenylboronic acid pinacol ester which is the closest to the structure of 3-amino-4-fluorophenylboronic acid basically uses 2-fluoro-5-bromoaniline and pinacol diboron in PdCl 2 (dppf) prepared under catalysis. It is theoretically possible to prepare 3-amino-4-fluorophenylboronic acid from 3-amino-4-fluorophenylboronic acid pinacol ester depinacol, but in this way, there is one ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): C07F5/02
CPCC07F5/025
Inventor 王宪学郑鹏
Owner DALIAN NETCHEM CHIRAL TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap