Novel cyclic depsipeptide derivative and pest control agent comprising same
一种环状、化合物的技术，应用在氨基甲酸衍生物制备、杀生物剂、用于生物控制的化学品等方向，能够解决没有公开化合物、没有建议化合物对有害生物防除效果等问题
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
preparation example Construction
[0151] Preparation of compounds of the present invention
[0152] The compounds of the present invention can be prepared by those skilled in the art according to the methods described in Nobuo Izumiya, Tetsuo Kato, Haruhiko Aoyanagi, and Michinori Waki, "Pepuchido Gosei No Kiso To Jikken (Basics and Experiments of Peptide Synthesis)," Maruzen Co., Ltd., 1985. This method will be described in further detail.
[0153] The compound of formula (1) can be produced by cyclization of the compound of formula (2) (linear octadepsipeptide):
[0154]
[0155] where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R' 1 , R' 2 , R' 3 and R' 4 as defined above. Specifically, the compound of formula (2) can be produced by reacting the compound of formula (2) by using a suitable condensing agent and adding a suitable inert solvent to obtain a dilute solution in the presence of a basic reaction auxiliary agent.
[0156] All condensing agents suitable for the preparation of ami...
Embodiment
[0370] The present invention is further illustrated by the following examples, which should not limit the invention.
preparation example 1
[0372] Preparation Example 1: Synthesis of (R)-(+)-2,3-epoxypropionic acid benzyl ester
[0373] L-serine (100 g) and 340 g of potassium bromide were dissolved in 600 ml of water at 0°C, and 47% aqueous hydrogen bromide was added dropwise thereto. When the reaction solution became uniform, 200 ml of 5N sodium nitrite solution was added dropwise. The mixture was stirred at 0 °C for 30 min, then at room temperature for 24 hr. Diethyl ether was added to the reaction solution, and the mixture was extracted 5 times. The ether phase was dried over sodium sulfate and concentrated. The residue was dissolved in ethanol, and 9.5N potassium hydroxide ethanol solution was added dropwise at -40°C. The mixture was stirred at room temperature for 24 hr, and the reaction solution was concentrated. The obtained white solid was suspended in ethanol, the suspension was stirred at 60° C. for 1 hour, and then filtered through Kiriyama Rohto to collect the white solid. The collected white soli...
PUM
Login to View More Abstract
Description
Claims
Application Information
Login to View More