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Application of parabacteroides merdae in treating or preventing rheumatoid arthritis or related diseases

A technology of Parabacteroides faecalis, rheumatoid, applied in the field of microbiology, can solve the problem of no effective treatment or cure

Active Publication Date: 2015-04-29
BGI SHENZHEN CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Since the etiology and pathogenesis are not yet fully understood, although some progress has been made in the treatment of RA, it is still in the stage of controlling or relieving symptoms, and there is no effective treatment or cure.

Method used

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  • Application of parabacteroides merdae in treating or preventing rheumatoid arthritis or related diseases
  • Application of parabacteroides merdae in treating or preventing rheumatoid arthritis or related diseases
  • Application of parabacteroides merdae in treating or preventing rheumatoid arthritis or related diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Example 1 Identification of beneficial bacteria for the treatment or prevention of rheumatoid arthritis

[0070] 1.1 Sample collection and DNA extraction

[0071] A total of 212 volunteers' feces, tartar and saliva samples were collected from Peking Union Medical College Hospital. The sample information is shown in Table 1. Among them, they were divided into training group and experimental group. The training group consisted of 157 volunteers, of which 77 were untreated RA cases and 80 were healthy subjects (controls). In the experimental group, 34 volunteers formed 17 "case-health" pairs, of which 8 were related by blood, and the other 9 were not related by blood; the other 21 volunteers treated RA with DMARD (disease-modifying antirheumatic drugs) case.

[0072] Fecal samples were collected and transported frozen and quickly transferred to -80°C for DNA extraction (refer to Qin, J. et al. A metagenome-wide association study of gut microbiota in type 2diabetes. Natur...

Embodiment 2

[0098] Example 2 Animal Experiment Verification

[0099] In order to verify that the beneficial bacteria for treating or preventing rheumatoid arthritis in Table 2, Table 3, Table 4, and Table 5 of Example 1 were determined, the inventors carried out animal experiments on each bacterial species, and used the available strains of the bacterial species to verify its efficacy.

[0100] experimental method

[0101] 1. Modeling and drug administration

[0102] 6-8 weeks old SPF (Specific pathogen free) grade male DBA / 1J mice were purchased from Shanghai Laboratory Animal Center, Chinese Academy of Sciences, and housed in IVC (individual ventilated cage) rat cage system (purchased from Suzhou Fengshi Laboratory Animal Equipment Co., Ltd. ), indoor temperature 22 ~ 24 ℃, humidity 40% ~ 60%, daily light for 12 hours, free food and water. After 2 weeks of adaptive feeding, they were randomly divided into 5 groups (model control group, bacterial agent group 1, bacterial agent group 2...

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Abstract

The invention provides an application of parabacteroides merdae in treating or preventing rheumatoid arthritis or related diseases thereof, and also provides a pharmaceutical composition, a medicament, a food and a feed containing the parabacteroides merdae. By providing the parabacteroides merdae for animals, an anti-inflammatory effect can be effectively brought into play, the symptoms of rubefaction and swelling of joints can be effectively improved, and the symptoms of arthritis can be obviously relieved, so that the parabacteroides merdae can be effectively used for treating or preventing the rheumatoid arthritis or the related diseases thereof.

Description

technical field [0001] The present invention relates to the field of microbiology, in particular, to the use of Parabacteroides faecalis in the treatment or prevention of rheumatoid arthritis or its related diseases, and also to pharmaceutical compositions, medicines, foods and feeds containing Parabacteroides faecalis. Background technique [0002] Rheumatoid arthritis (RA) is a systemic autoimmune disease that mainly affects the synovium of the joints, followed by the serosa, heart, lungs, blood vessels, nerves and other connective tissues. In the acute phase, the main manifestations of inflammation are synovial angioedema and synovitis. If not diagnosed and treated in time, the acute inflammatory response will subside, the exudation will gradually be absorbed, the pannus will form in the synovium, and the synovial cells will proliferate significantly. Then cause articular cartilage destruction, bone tissue inflammation, necrosis and fibrous connective tissue hyperplasia. ...

Claims

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Application Information

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IPC IPC(8): A61K35/74A23L1/30A23K1/16A61P19/02A61P29/00
Inventor 冯强张东亚贾慧珏刘传肖亮王俊
Owner BGI SHENZHEN CO LTD
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