Method for extracting herbaceous plants for external use by virtue of small-molecular cutting technology

A technology of herbal plants and cutting technology, which is applied in the field of extracting herbal plants with small molecule cutting technology, which can solve the problems of underutilization and incomplete extraction of medicinal ingredients

Active Publication Date: 2015-04-29
马建
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method does not carry out ultrafine grinding and cell wall breaking of Chinese herbal medicines, so that the extraction of medicinal ingredients is not complete and has not been fully utilized.

Method used

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  • Method for extracting herbaceous plants for external use by virtue of small-molecular cutting technology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) Take 500g of Forsythia forsythia removed from mildew and impurities, crush it and dissolve it in 2500mL of acetone, filter the slurry to recover the filtrate.

[0027] (2) The solvent and the solute in the recovered filtrate are separated, and the separated solute is subjected to ultrafine pulverization treatment using an ultrafine pulverizer. Ultrafine pulverization: Forsythia is pulverized three times in a superfine pulverizer, passed through a 100-mesh sieve, and then pulverized twice, passed through a 200-mesh sieve, and pulverized for 10 minutes each time.

[0028] (3) Use the dry method to break the cell wall of the solute after ultrafine pulverization;

[0029] (4) Put 250g of the solute and 100ml of entrainer ethanol into the extraction kettle of the supercritical fluid extraction apparatus after the wall breaking treatment. The flow rate of the supercritical fluid entering the extraction kettle is 30L / h. The temperature of the extraction kettle is 40°C and ...

Embodiment 2

[0034] (1) Take 500g of pinellia that removes mildew and impurities, crush it and dissolve it in 3000mL of ethyl acetate, filter the slurry to recover the filtrate.

[0035] (2) The solvent and the solute in the recovered filtrate are separated, and the separated solute is subjected to ultrafine pulverization treatment using an ultrafine pulverizer. Superfine pulverization Pinellia was pulverized three times in a superfine pulverizer, passed through a 100-mesh sieve, and then pulverized twice, crossed a 200-mesh sieve, and pulverized for 10 minutes each time.

[0036] (3) Use the dry method to break the cell wall of the solute after ultrafine pulverization;

[0037] (4) Put 250g of solute and 120ml of entrainer propylene glycol into the extraction kettle of the supercritical fluid extraction apparatus after the wall-breaking treatment. The flow rate of the supercritical fluid entering the extraction kettle is 40L / h. 32MPa, the extraction time with carbon dioxide supercritical...

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Abstract

The invention discloses a method for extracting herbaceous plants for external use by virtue of a small-molecular cutting technology. According to the method disclosed by the invention, traditional Chinese medicinal materials are milled, ground, wall-broken and extracted, so that raw materials are fully used. By virtue of superfine grinding and cell wall-breaking technologies, the herbaceous plants are cut into small-molecular materials which are easy to be absorbed. Through supercritical carbon dioxide extracting technology, the active ingredients in the traditional Chinese medicinal materials can be effectively extracted respectively, and the residue of an organic solvent in the crude medicines can be removed.

Description

technical field [0001] The invention relates to the field of medicine extraction, in particular to a method for extracting herbal plants for external use by using small molecule cutting technology. Background technique [0002] The development of pharmaceutical preparations has gone through four stages: the first generation of preparations is a general dosage form, such as capsules, tablets, suppositories, injections, etc.; the second generation is prodrugs and sustained and controlled release preparations; the third generation is controlled release preparations ; The fourth generation is a targeted agent. The development of new drug dosage forms, new technologies, new processes and new excipients are inseparable from these four stages of drug preparation development. At present, the drug delivery system, that is, the third-generation and fourth-generation drug dosage forms has become an important development direction in the field of pharmacy, and the sustained and control...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/00
Inventor 马建
Owner 马建
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