Preparation method of high-purity refined monensin sodium

A technology of monensin sodium and monensin, which is applied in the field of preparation of high-purity monensin sodium fine products, can solve problems such as consumption and difficulty in filtrate, and achieves reduction of toxic reactions, less solvent consumption, and improved safety. sexual effect

Inactive Publication Date: 2015-04-29
山东齐发药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since monensin is almost insoluble in water, and the pretreatment steps of the process are all carried out in the water phase, and then filtered, it is not easy to obtain a high-concentration filtrate containing monensin sodium, which requires a lot of of water

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A preparation method of high-purity monensin sodium boutique, the steps are as follows:

[0036] (1) pH adjustment: collect 20 tons of 42000u / mL monensin fermentation broth, and adjust the pH value of the feed solution to 8.5 with sodium hydroxide;

[0037] (2) Filtration: filter the fermented liquid processed in step (1) with a plate frame equipped with a filter cloth, and remove the moisture in the fermented liquid to obtain 3.3 tons of filter cakes containing monensin sodium;

[0038] (3) Leaching: according to 4.8m 3 Ratio of methanol / ton of monensin sodium filter cake Add 16m 3 methanol, then drop into 3.3 tons of filter cake obtained in step (2), stir for 60 minutes, filter, collect the methanol extract, then add an equal volume of methanol solution in the extraction tank, extract for 40 minutes, filter, collect the methanol extract The extraction solution is mixed with the methanol extraction solution for the first time for concentration in the next step;

[0...

Embodiment 2

[0046] A preparation method of high-purity monensin sodium boutique, the steps are as follows:

[0047] (1) pH adjustment: collect 22.5 tons of 37500u / mL monensin fermentation liquid, and adjust the pH value of the feed liquid to 9.3 with sodium hydroxide.

[0048] (2) Filtration: filter the fermented liquid processed in step (1) with a plate frame equipped with a filter cloth, and remove the moisture in the fermented liquid to obtain 3.6 tons of filter cakes containing monensin sodium;

[0049] (3) Leaching: according to 5.1m 3 Ratio of methanol / ton of monensin sodium filter cake Add 18.5m 3 Methyl alcohol, then drop into 3.6 tons of filter cakes that step (2) obtains, stir 50 minutes, filter, collect the methanol extract, then add the methanol solution of equal volume in the extraction tank according to the above ratio, extract 30 minutes, filter, Collect the methanol extract and mix it with the first methanol extract for concentration in the next step;

[0050] Extract t...

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PUM

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Abstract

The invention relates to a preparation method of high-purity refined monensin sodium, which comprises the steps of adjusting the pH value of monensin fermented liquid, and sequentially filtering, lixiviating, concentrating, crystallizing, refining, centrifugalizing and drying the obtained product, so that refined monensin sodium is obtained. A pure monensin product produced by using the method is high in purity and good in impurity removal rate, and conforms to the safety requirements of medication.

Description

technical field [0001] The invention relates to the field of production of biological fermentation products, in particular to a preparation method of high-purity monensin sodium refined product. Background technique [0002] Monensin is a monovalent polyether ionophore anticoccidial drug with broad-spectrum anticoccidial activity. The mechanism of its coccidial action is to interfere with the normal penetration of K+ and Na+ in the coccidia cells, so that a large amount of Na+ enters the cells. In order to balance the osmotic pressure, a large amount of water enters the coccidia cells, causing swelling and death. It has effects on chicken poisoning, tenderness, giant, displacement, heap type, Brucelli and other Eimeria. It is also effective against Eimeria glandularis and Eimeria turkeys in turkeys, dispersal of quails and Eimeria laitai, and Eimeria jasperi and Eimeria azadi in lambs. The peak period of monensin's action is in the first 2 days of the life cycle of coccidi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/10
CPCC07D493/10
Inventor 王守奎丁新仁张效军耿英明张莉
Owner 山东齐发药业有限公司
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