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Method for improving hydrophilicity and flexibility of polypeptide film by polytrimethylene carbonate and carboxymethyl chitosan

A technology of carboxymethyl chitosan and methyl carbonate monotridecyl ether, which is applied in the field of polymer film preparation to achieve the improvement of hydrophilicity and flexibility of polypeptide modified films, simple operation and easy mastery Effect

Inactive Publication Date: 2015-04-29
SHANDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the improvement of the hydrophilicity and flexibility of polypeptide membranes with polytrimethylene carbonate and carboxymethyl chitosan

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 1) Synthesis of Polypeptide-Polytrimethylene Carbonate Block Copolymer

[0018] 16.1 g of poly(r-benzyl-L-glutamate) (molecular weight 80,000) and 7 g of carboxy-terminated polytrimethylene carbonate monotridecyl ether (molecular weight 3,000) were added to the dry reactor ), add 308 ml DMSO, and then add 0.048 g N,N' -Dicyclohexylcarbodiimide, under an inert atmosphere, stirred and reacted at 25°C for 2 days, terminated the reaction, and obtained the target product by filtration, dialysis, and drying;

[0019] 2) Synthesis of carboxymethyl chitosan-polytrimethylene carbonate graft copolymer

[0020] Add 3.5 g of carboxymethyl chitosan (molecular weight: 5000) and 9 g of amino-terminated polytrimethylene carbonate monotridecyl ether (molecular weight: 3000) into the dry reactor, add 163 ml dimethylmethylene Sulfone, add 0.165 g N,N' -Dicyclohexylcarbodiimide, under an inert atmosphere, stirred and reacted at 25°C for 2 days, then terminated the reaction, filtered, ...

Embodiment 2

[0025] 1) Synthesis of Polypeptide-Polytrimethylene Carbonate Block Copolymer

[0026] 16.3 g of poly(r-ethyl-L-glutamate) (molecular weight 85,000) and 7 g of carboxy-terminated polytrimethylene carbonate monotridecyl ether (molecular weight 3,500) were added to the dry reactor , add 310 ml of dimethyl sulfoxide, then add 0.031 g of N,N'-diisopropylcarbodiimide, under an inert atmosphere, stir and react at 27°C for 3 days, terminate the reaction, filter, dialyze, and dry, get the target

[0027] 2) Synthesis of carboxymethyl chitosan-polytrimethylene carbonate graft copolymer

[0028] Add 3 g of carboxymethyl chitosan (molecular weight: 5500) and 9 g of amino-terminated polytrimethylene carbonate monotridecyl ether (molecular weight: 3500) into the dry reactor, add 158 ml dimethylmethylene Sulfone, then add 0.08 g N,N' -Diisopropylcarbodiimide, under an inert atmosphere, stirred at 28°C for 3 days, then terminated the reaction, filtered, dialyzed, and dried to obtain the ...

Embodiment 3

[0033] 1) Synthesis of Polypeptide-Polytrimethylene Carbonate Block Copolymer

[0034] 16.5 g of poly(r-methyl-L-glutamate) (molecular weight 92,000) and 7 g of carboxy-terminated polytrimethylene carbonate monotridecyl ether (molecular weight 4,000) were added to the dry reactor , add 310 ml dimethyl sulfoxide, then add 0.046 g 3-ethyl-1-(3-dimethylaminopropyl) carbodiimide, under inert atmosphere, stir the reaction at 30°C for 4 days to terminate the reaction, Through filtration, dialysis, and drying, the target object is obtained;

[0035] 2) Synthesis of carboxymethyl chitosan-polytrimethylene carbonate graft copolymer

[0036] Add 3.1 g of carboxymethyl chitosan (molecular weight: 6000) and 9.2 g of amino-terminated polytrimethylene carbonate monotridecyl ether (molecular weight: 4000) into the dry reactor, add 158 ml dimethylmethylene Sulfone, then add 0.141 g of 3-ethyl-1-(3-dimethylaminopropyl) carbodiimide, under an inert atmosphere, stir and react at 35°C for 2 day...

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PUM

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Abstract

The invention discloses a method for improving hydrophilicity and flexibility of a polypeptide film by polytrimethylene carbonate and carboxymethyl chitosan. The method comprises the following steps: 1) adding carboxyl-terminated polytrimethylene carbonate monotridecyl ether, a solvent, a condensation agent and a polypeptide homopolymer into a drying reactor and reacting to obtain a polypeptide-polytrimethylene carbonate block copolymer; 2) adding amino-terminated polytrimethylene carbonate monotridecyl ether, the solvent, the condensation agent and carboxymethyl chitosan into the drying reactor and reacting to obtain a carboxymethyl chitosan-polytrimethylene carbonate graft copolymer; and 3) adding the polypeptide-polytrimethylene carbonate block copolymer, the carboxymethyl chitosan-polytrimethylene carbonate graft copolymer and the solvent into the drying reactor, mixing, then forming a film by a tape casting method, and drying to obtain a target object. The method disclosed by the invention is simple in preparation process, and the hydrophilicity and flexibility of the obtained modified film are greatly improved.

Description

technical field [0001] The invention relates to a method for improving the hydrophilicity and flexibility of a polypeptide film with polytrimethylene carbonate and carboxymethyl chitosan, belonging to the technical field of polymer film preparation. Background technique [0002] Polypeptide is a biomaterial with good biocompatibility and biodegradability. Polypeptide film can be used as artificial skin, etc., but the polypeptide film is relatively stiff and lacks hydrophilicity, which limits its application. Polytrimethylene carbonate has better biocompatibility and biodegradability, and is relatively soft. Carboxymethyl chitosan has good biocompatibility and biodegradability, and has good hydrophilicity. First, the polytrimethylene carbonate segment is introduced into the polypeptide segment and the carboxymethyl chitosan segment respectively to form a polypeptide-polytrimethylene carbonate block copolymer and a carboxymethyl chitosan-polytrimethylene Carbonate-based gra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L87/00C08J5/18C08G81/00
Inventor 朱国全董抒华崔红卫
Owner SHANDONG UNIV OF TECH
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