Method for simultaneously measuring content of nicotine, 1,2-propylene glycol and glycerol in electronic smoke sol

A technology of propylene glycol and glycerol, which is applied in the field of physical and chemical inspection of electronic cigarette products, can solve the problems of time-consuming and cumbersome operation of cold hydrazine capture method, incomplete application of electronic cigarettes, large amount of capture liquid, etc., and achieves repeatability and reliability. The effect of good recovery rate, filling technical gaps, and easy operation

Active Publication Date: 2015-05-13
CHINA NAT TOBACCO QUALITY SUPERVISION & TEST CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many reports on the determination of nicotine content in tobacco and cigarette smoke[3, 4], but the weight, shape, aerosol (smoke) generation mechanism, and smoking of electronic cigarettes and traditional cigarettes are different. There are great differences in mode, chemical composition, single-puff nicotine content and content difference between puffs, so the determination method of nicotine in mainstream smoke of traditional cigarettes is not fully applicable to e-cigarettes[5 , 6]
There are relatively few studies on the determination of nicotine content in e-cigarette aerosol, such as Goniewicz, M[7] and Michael, L[8] etc. using cold hydrazine to capture- Gas chromatography

Method used

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  • Method for simultaneously measuring content of nicotine, 1,2-propylene glycol and glycerol in electronic smoke sol
  • Method for simultaneously measuring content of nicotine, 1,2-propylene glycol and glycerol in electronic smoke sol
  • Method for simultaneously measuring content of nicotine, 1,2-propylene glycol and glycerol in electronic smoke sol

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preparation example Construction

[0060] 1) Preparation of nicotine standard working solution: Accurately weigh 100 mg of nicotine into a 100 mL brown volumetric flask, dissolve it in isopropanol to obtain a nicotine standard stock solution, and then accurately measure 0.02, 0.05, 0.1, 0.2, 0.5, 1.0, 2.0 mL standard stock solution in 10 mL brown volumetric flask, and then accurately add 100 μL internal standard stock solution (20 mg / mL n-heptadecane in isopropanol) Distilled to volume with propanol to obtain a nicotine standard working solution with a 7-level concentration gradient.

[0061] 2) Preparation of 1,2-propanediol and glycerol mixed standard working solution: Accurately weigh 500 mg of 1,2-propanediol and 500 mg of glycerol in a 100 mL volumetric flask, dissolve in isopropanol to volume, and prepare To obtain 1,2-propanediol and glycerol standard stock solutions, and then accurately measure 0.02, 0.05, 0.1, 0.2, 0.5, 1.0, 2.0 mL of mixed standard stock solutions in 10 mL brown volumetric flasks, and...

Embodiment 1

[0076] According to the above-mentioned method for simultaneously measuring the contents of nicotine, 1,2-propanediol and glycerol in electronic cigarette aerosol, select an electronic cigarette product, smoke 50 puffs in the ISO: 3308 smoking mode, and measure the gas The contents of nicotine, 1,2-propanediol and glycerol in the sol were 0.199 mg, 13.682 mg and 5.412 mg, respectively.

Embodiment 2

[0078] According to the above-mentioned method for simultaneously determining the content of nicotine, 1,2-propanediol and glycerol in electronic cigarette aerosol, select an electronic cigarette product, smoke 50 puffs under the Canada Health Intense smoking mode, and measure the gas The contents of nicotine, 1,2-propanediol and glycerol in the sol were 0.305 mg, 19.596 mg and 7.264 mg, respectively.

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Abstract

The invention discloses a method for simultaneously measuring content of nicotine, 1,2-propylene glycol and glycerol in electronic smoke sol. The method comprises the following steps: smoking electronic cigarettes by utilizing a smoking machine provided with a switch connection device, trapping the nicotine, 1,2-propylene glycol and glycerol in the gas sol by adopting a Cambridge filter, by taking an isopropyl alcohol solution added with an interior label as an extraction agent, extracting the nicotine on the filter by using an oscillation extraction method, analyzing by matching a gas chromatograph with a hydrogen flame ionization detector, and performing internal standard method determination. The method disclosed by the invention has the advantages that the efficiency of the adopted measurement method is high, the switch connection device is high in air impermeability, simple and effective, a linear relation among the nicotine, 1,2-propylene glycol and glycerol is good in the respective linearity range, the detection limit is 0.40-2.16ug/mL, the average recovery rate of three labeling levels is between 96.0 and 102.0 percent, and the relative standard deviation is smaller than 3.60 percent. Therefore, the method is high in sensitivity and high in repeatability and recovery rate.

Description

technical field [0001] The invention relates to the technical field of physical and chemical inspection of electronic cigarette products, in particular to a gas chromatography method for simultaneously measuring the contents of nicotine, 1,2-propanediol and glycerol in electronic cigarette aerosol. Background technique [0002] Electronic cigarettes (e-cigarettes), also known as electronic nicotine delivery systems (ENDS), are a new form of nicotine intake that looks similar to cigarettes. Over the years, e-cigarettes have used "health care", "quit smoking" and "cleaning the lungs" as their promotional slogans, with the Internet as the main marketing channel, and their sales in China have increased significantly. However, there are still few studies on the determination of the main components of e-cigarette aerosols. [0003] Nicotine, 1,2-propanediol and glycerol are the main chemical components in electronic cigarette pods and e-liquids. 1,2-Propanediol and glycerin are ...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06
Inventor 韩书磊陈欢刘彤田永峰姜兴益庞永强侯宏卫胡清源
Owner CHINA NAT TOBACCO QUALITY SUPERVISION & TEST CENT
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