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A kind of chitosan hydrogel dressing and preparation method thereof

A technology of chitosan and sugar water, applied in medical science, bandages, absorbent pads, etc., can solve the problems of allergies, long healing period, difficult process control, etc., to enhance the effect of cross-linking reaction, reduce the healing period, avoid The effect of secondary damage

Active Publication Date: 2016-09-28
GUANGDONG TAIBAO MEDICAL SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many studies on preparing chitosan into hydrogel for treating wounds, but there is no report on the preparation of multifunctional and easily absorbable chitosan hydrogel with low molecular weight chitosan
The existing hydrogel dressings are prone to adhesion to the wound surface, low moisture permeability, long healing cycle, tissue hyperplasia, and unsatisfactory hemostasis effects, which lead to long postoperative nursing cycles and many nursing steps, so they are not clinically used. the best choice
[0003] In addition, in chitosan production industry, chitosan is prepared by using strong acid and strong base. The concentration of strong base used in this process is 40%~60%, and the reaction temperature is generally 100~140°C. It is difficult to control and causes serious pollution in production, and it is easy to leave acid and alkali at the same time, leading to allergies during clinical use

Method used

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  • A kind of chitosan hydrogel dressing and preparation method thereof
  • A kind of chitosan hydrogel dressing and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1. The preparation method of low molecular mass chitosan: after the Antarctic krill was thawed at 4°C, the whole shrimp was mashed by a tissue masher, and 100 g of the mashed tissue fluid was weighed and put into a fermenter. The activated lactic acid bacteria were inoculated with a volume fraction of 10%, the activated medium was MRS medium, the initial pH of the fermentation was 6.5, the fermentation temperature was 42°C, and the fermentation time was 72 h; after the fermentation, the filtrate was filtered and the filter residue was collected , and wash the filter residue with distilled water several times to remove impurities such as protein, calcium lactate, astaxanthin, and dry the filter residue after washing until colorless. = 1:15 After mixing evenly, ultrasonic treatment at 50°C for 12 h; After cleaning, dissolve the obtained solid in acetic acid with a volume concentration of 1%, filter off the insoluble matter, collect the filtrate, and adjust the pH of the f...

Embodiment 2

[0029] 1. Experimental group: low molecular weight chitosan. Preparation method: Antarctic krill was thawed at 4°C, and the whole shrimp was mashed by a tissue masher, and 100 g of the mashed tissue fluid was weighed and put into a fermenter. The tank was inoculated with activated lactic acid bacteria with a volume fraction of 10%, the activated medium was MRS medium, the initial pH of the fermentation was 6.5, the fermentation temperature was 42°C, and the fermentation time was 72 h; after the fermentation, the filtrate was filtered and collected filter residue, and wash the filter residue with distilled water several times to remove impurities such as protein, calcium lactate, astaxanthin, and dry the filter residue after washing until colorless, and filter the residue and the NaOH solution with an alkali mass concentration of 15% according to the mass volume ratio (W / V ) = 1:15 After mixing evenly, ultrasonic treatment was performed at 50°C for 4 h; after ultrasonication, t...

Embodiment 3

[0036] 1. The preparation method of low molecular mass chitosan: after Antarctic krill is thawed at 4°C, the whole shrimp is mashed by a tissue masher, and 100 g of the mashed tissue fluid is weighed and put into a fermenter, and inoculated in the fermenter The volume fraction of activated lactic acid bacteria is 10%, the activation medium is MRS medium, the initial pH of fermentation is 6.5, the fermentation temperature is 42°C, and the fermentation time is 72 h; Rinse the filter residue with distilled water several times to remove impurities such as protein, calcium lactate, and astaxanthin. After washing until colorless, dry the filter residue. Dilute the filter residue and NaOH solution with an alkali mass concentration of 15% according to the mass volume ratio (W / V)=1 : 15 After mixing evenly, ultrasonic treatment was performed at 50°C for 4 h; after ultrasonication, the mixed solution was adjusted to neutrality with 4mol / L acidic HCl solution, and then rinsed repeatedly ...

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Abstract

The invention belongs to the field of medical dressings and in particular relates to a chitosan hydrogel dressing and a preparation method of the chitosan hydrogel dressing. The chitosan hydrogel dressing comprises the following components in parts by weight: 1-5 parts of low-molecular-weight chitosan, 0.25-1 part of aloe, 1-3 parts of a percutaneous absorption accelerant, 0.05-1 part of a hemostasis material and 2-5 parts of water. The chitosan hydrogel dressing is easily absorbed by wound surfaces, is excellent in moisture penetrability and air penetrability, is capable of providing wet healing environment for wounds and facilitating the heating of the wounds, and has a hemostasis effect.

Description

technical field [0001] The invention belongs to the field of medical dressings, in particular to a chitosan hydrogel dressing and a preparation method thereof. Background technique [0002] Chitosan and its derivatives can promote the growth of epithelial cells and wound healing. Chitosan can be absorbed by normal skin tissue, but the absorption capacity of injured skin tissue is greatly reduced. Studies have shown that fat-soluble substances and substances with small molecular weights are easily absorbed by the body. Therefore, for wounded tissues, it is very necessary to select low molecular weight chitosan to prepare medical dressings. There are many studies on preparing chitosan into hydrogel for treating wounds, but there is no report on the preparation of multifunctional and easily absorbable chitosan hydrogel with low molecular weight chitosan. The existing hydrogel dressings are prone to adhesion to the wound surface, low moisture permeability, long healing cycle,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/44A61L15/64C12P19/26
Inventor 卢亢陈泽楚李婷陈锦涛
Owner GUANGDONG TAIBAO MEDICAL SCI TECH
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