Drug for intrapleural hyperthermic perfusion therapy

A hyperthermic perfusion and drug technology, applied in the field of thoracic hyperthermic perfusion therapy, can solve the problems of reducing recurrence rate, limited thoracic movement, lack of elasticity, etc., to relieve pleural irritation pain, reduce platelet aggregation rate and aggregation speed Effect

Inactive Publication Date: 2015-05-27
阮秀云
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are two main perfusion fluids for hyperthermic pleural perfusion therapy: one is normal saline, which has poor timeliness in controlling pleural effusion and has a high recurrence rate; the other is chemotherapy drugs, such as cisplatin and nedaplatin, whose mechanism of action lies in the local Anti-cancer and promotion of pleural adhesions, but clinically, due to excessive adhesion promotion, a large amount of cellulose is deposited on the pleura, capillaries and fibroblasts in

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1, the weight ratio of raw materials: 2 parts of crab seven, 8 parts of longan longan, 2 parts of water safflower seeds, 16 parts of eucalyptus leaves, 16 parts of sea sinensis, 6 parts of fruit upper leaves, 6 parts of fragrant osmanthus, 16 parts of ginger, 16 parts of cicadas, 6 parts of mussels.

[0029] The preparation method of embodiment 1 is:

[0030] (1) The above-mentioned raw materials are screened to remove impurities, measured, mixed, and pulverized, and then put into the percolation kettle, add 3 times the weight of the raw materials and ethanol with a volume concentration of 98%, heat to 60°C, and carry out percolation after heating for 5 hours;

[0031] (2) Pour the leachate obtained in step 1 into the distillation kettle to concentrate, return the distillate to the percolation kettle to continue diafiltration, control the filtration rate to 120 ml / min kg, and circulate the diafiltration extraction until the color of the filtrate does not change ...

Embodiment 2

[0036] Example 2, the weight ratio of raw materials: 1 part of crab seven, 6 parts of longan longan, 1 part of water red flower seed, 20 parts of eucalyptus leaves, 10 parts of sea sage, 12 parts of fruit upper leaves, 12 parts of sand ginger, fragrance 3 parts of osmanthus, 12 parts of cicadas, 3 parts of mussels.

Embodiment 3

[0037] Example 3, the weight ratio of raw materials: 3 parts of crab seven, 9 parts of longan longan, 5 parts of water safflower seeds, 12 parts of eucalyptus leaves, 25 parts of sea sinensis, 3 parts of fruit upper leaves, 20 parts of sand ginger, fragrance 12 parts of osmanthus, 20 parts of cicadas, 12 parts of mussels, 20 parts of sweet clover, 12 parts of fennel.

[0038] The Chinese medicine of embodiment 2,3 can be prepared by the following method:

[0039](1) Extract the volatile oils from the coarse powder of Piper longum longum, Chickweed, eucalyptus leaves, Qingxianggui, cicada slough, Shuihonghuazi, sand ginger, and sweet-scented clover, and collect them and mix them for later use, and the dregs for later use;

[0040] (2) Mix the fruit leaves, crab seven, sea sage, mussels and the dregs of the medicine in step 1, add 3 times the amount of water, decoct 2 times, 1 hour each time, combine the decoction, let stand and filter After that, the filtrate is used for subse...

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PUM

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Abstract

The invention discloses a drug for intrapleural hyperthermic perfusion therapy, and is used for solving the therapy problem of cancerous hydrothorax. The drug is characterized by being prepared from the medicinal raw materials including rhizoma arisaematis, folium eucalypti, denseflower bulbophyllum herb, mussel, fragrant sarcococca herb, periostracum cicada, motherwort fruit, sweet clover, kaempferiae, fruits of polygonum orientale and sargassum fusiforme. Clinical experiments prove that the drug disclosed by the invention has good curative effect and higher safety for treating cancerous hydrothorax; and therefore, the drug is worthy of being clinically applied and popularized.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a medicine for pleural hyperthermic perfusion therapy. Background technique [0002] Hyperthermic perfusion therapy is a new therapy for tumors treated by hyperthermia. Its principle is to use physical energy to heat the liquid and infuse it into the tumor site, so that the temperature of the tumor tissue rises to the effective treatment temperature and maintains it for a certain period of time. The difference in temperature tolerance can achieve the therapeutic purpose of making tumor cells apoptosis without damaging normal tissues. [0003] For tumor patients who have already developed cancerous pleural effusion, the pleural cavity is filled with fluid. It is a new idea and theory in recent years to perform hyperthermic pleural perfusion therapy while draining pleural effusion. At present, there are two main perfusion fluids for hyperthermic pleural perfusion therap...

Claims

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Application Information

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IPC IPC(8): A61K36/906A61P7/10A61P11/00A61K35/64A61K35/618
Inventor 阮秀云王蓉华孟琴
Owner 阮秀云
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