Method for extracting silymarin by using ethyl acetate as extraction solvent

Abstract

The invention provides a method for extracting silymarin by using ethyl acetate as an extraction solvent. The method is characterized by comprising the following steps: (1) removing fatty oil from silybum marianum seeds; (2) grinding oil-pressed cake, and putting into an extraction tank; (3) injecting a proper amount of ethyl acetate from the top end of the extraction tank; (4) putting an extracting solution which is immersed with cake powder into an evaporation tank after static immersion, and injecting a fresh solvent into the charge layer in the extraction tank from the top end of the extraction tank to dynamically balance solvents flowing in and out of the extraction tank; (5) dynamically extracting; (6) concentrating; (7) stopping concentrating until the density is 1.2g / ml, and transferring fluid extract obtained by concentration into an extract washing machine; (8) degreasing for the second time; (9) baking; (10) grinding, and screening products with different specifications for users. According to the method, the existing ethyl acetate process is improved, the operation is simplified, and raw materials of high-content liver-protecting medicines can be provided to clients, so that the method has considerable social and economic benefits.

Description

technical field [0001] The invention relates to a method for extracting silymarin, in particular to a method for extracting silymarin using ethyl acetate as an extraction solvent, which belongs to the extraction and purification technology for extracting active ingredients from silymarin seeds. Background technique [0002] Milk thistle is also known as milk thistle, mouse thistle, artichoke, milk pheasant, etc., and its Latin name is Silybum mariaum. It is native to the Mediterranean coast and is wildly distributed in the grasslands of western Asia. It is a biennial or annual herb. It is currently in Europe. It is cultivated in Asia, Africa and North and South America. [0003] Milk thistle is a kind of medicinal economic crop. In the 1960s and 1970s, a group of scientists such as German botanist H. Wagner and Japanese botanist Tsunematsu found that the seeds contained silymarin, a drug for treating diseases. , invented the extraction technology of this drug and determined...

AI Technical Summary

Problems solved by technology

[0007] Looking at these extraction processes, methanol extracts are generally not used by manufacturers because they are more harmful to the health of on-site operations; acetone, because of its high extraction rate, reduces the proportion of active ingredients in the product; and ethyl acetate extracts Although the content of active ingredients in the product is high, its yield is low and the operation is lengthy

[0008] In order to meet the needs of different foreign customers, the applicant has effectively improved the original ethyl acetate extraction process through several years of experimental research, removed the reconstitution and inorganic back extraction process, and added a method to prevent the hardening of the extract during concentration. According to the research of the applicant, this preparation method after improving the production process is still blank