Preparation method and application of medicinal aqueous acrylic resin aqueous dispersion and product produced from medicinal aqueous acrylic resin aqueous dispersion

A technology of acrylic resin and dispersion, applied in water dispersion products and its application as polymer pharmaceutical excipients in solid pharmaceutical dosage forms, in the field of preparation of pharmaceutical acrylic resin water dispersion, can solve the problem of high aggregate content, Problems such as poor film formation, adverse effects on acrylic resin polymer structure and performance, etc., to achieve the effect of simple operation process and reduced residual monomer content

Active Publication Date: 2015-05-27
浙江瓯伦包衣技术有限公司
View PDF8 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] Although the above-mentioned methods are usually used in the preparation of medicinal acrylic resin aqueous dispersions, they all have the following disadvantages: the aggregate content is relatively high, generally based on 0.1%-0.5% or more of the total emulsion amount; Polymer latex with acrylic acid and its esters as monomers has a relatively coarse particle size, and the average particle size is generally 150-500nm
Due to these shortcomings, the aqueous dispersion product obtained by the preparation

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method and application of medicinal aqueous acrylic resin aqueous dispersion and product produced from medicinal aqueous acrylic resin aqueous dispersion
  • Preparation method and application of medicinal aqueous acrylic resin aqueous dispersion and product produced from medicinal aqueous acrylic resin aqueous dispersion
  • Preparation method and application of medicinal aqueous acrylic resin aqueous dispersion and product produced from medicinal aqueous acrylic resin aqueous dispersion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0107] Example 1 (ME-262)

[0108] Instruments: 100-liter experimental reaction kettle, water bath, paddle stirrer, temperature measuring device and processing control pipeline system for metering and feeding.

[0109] Preparation steps:

[0110] Heating the initial feed liquid to an internal temperature of 75°C, adding 5.6 parts of ammonium persulfate (6%) for 5 minutes, maintaining the temperature at 80°C and metering in 24.4 parts of the feed liquid dropwise, the dripping is completed within 1 hour, and the insulation reaction is 1 Hours, add 2.5 parts of isoascorbic acid (6%) to react for 5 minutes. Cool down to 58-60°C, add 4.6 parts of ferrous sulfate heptahydrate (0.1%) to react for 5 minutes, add 1.7 parts of tert-butyl hydroperoxide (6%) to react for 5 minutes, and drop the remaining dripping feed liquid into the The dripping was finished within 90-120 minutes and the feed liquid I was dripped within 120-150 minutes, and then the reaction was continued for 15 minute...

Embodiment 2

[0128] Example 2 (ME-261)

[0129] Instruments: 1 liter experimental reaction kettle, water bath, paddle stirrer, temperature measuring device and processing control pipeline system for metering and feeding.

[0130] Preparation steps:

[0131] Heat the initial feed solution to an internal temperature of 75°C, add 6.3 parts of ammonium persulfate (6%) and react for 5 minutes, then maintain the temperature at 80°C and add 48.8 parts of the dropwise feed solution dropwise, and finish the drop within 1.5 hours. After 1 hour, add 5.6 parts of isoascorbic acid (3%) and react for 5 minutes. Cool down to 58-60°C, add 4.6 parts of ferrous sulfate heptahydrate (0.1%) to react for 5 minutes, add 1.7 parts of tert-butyl hydroperoxide (6%) to react for 5 minutes, and drop the remaining dripping feed liquid into the The dripping was finished within 90-120 minutes and the feed liquid I was dripped within 120-150 minutes, and then the reaction was continued for 15 minutes. After adding 1....

Embodiment 3

[0149] Example 3 (ME-257)

[0150] Instruments: one 100-liter experimental reaction kettle, water bath, paddle stirrer, temperature measuring device and processing control pipeline system for metering and feeding.

[0151] Preparation steps:

[0152] Heat the initial feed liquid to an internal temperature of 75°C, add 3.3 parts of ammonium persulfate (6%) and react for 5 minutes, then maintain the temperature at 80°C and add 8 parts of the feed liquid dropwise, and finish the dripping within 1 hour. 1 hour, add 2.9 parts of isoascorbic acid (3%) and react for 5 minutes; cool down to 58-60° C., add 4.6 parts of ferrous sulfate heptahydrate (0.15%) and react for 5 minutes, add 5 parts of tert-butyl hydroperoxide ( 3%) after reacting for 5 minutes, drop the remaining dripping feed liquid in 90-120 minutes and feed liquid I in 120-150 minutes, then continue to react for 15 minutes; add 5 parts of tert-butyl After hydrogen peroxide (3%) reacted for 5 minutes, drop feed solution I...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Granularityaaaaaaaaaa
Login to view more

Abstract

The invention discloses a preparation method and application of a medicinal aqueous acrylic resin aqueous dispersion and a product produced from the medicinal aqueous acrylic resin aqueous dispersion. The preparation method adopts combination of a thermal decomposition initiation system and an oxidation and reduction initiation system and comprises the steps of preparing a seed latex in the thermal decomposition initiation system and the polymerizing the seed latex in the oxidation and reduction initiation system. The medicinal aqueous acrylic resin aqueous dispersion with the average size of less than 100nm, the coagulum content of less than 0.1% and the residual monomer content of less than 100ppm is prepared by adopting the preparation method. In addition, the invention further provides a product produced from the medicinal aqueous acrylic resin aqueous dispersion and application of the medicinal aqueous acrylic resin aqueous dispersion in solid medicinal preparations. The purpose of realizing low-cost industrial production can be achieved, and the situation that the production, application and popularization of the medicinal aqueous acrylic resin aqueous dispersion are limited strictly due to technology and cost factors in more than 30 years since the medicinal aqueous acrylic resin aqueous dispersion is introduced into China can be improved.

Description

technical field [0001] The invention belongs to the field of pharmaceutical polymer materials, and relates to a preparation method of a pharmaceutical acrylic resin water dispersion, the water dispersion product and its application as a polymer pharmaceutical auxiliary material in a solid pharmaceutical dosage form. Background technique [0002] Since the 1960s, a large number of polymer materials have entered the pharmaceutical field, which has promoted the application and development of polymer materials in the pharmaceutical field. In recent years, with the development of nanotechnology and material science, a large number of new preparations of nano-sized particles loaded with drugs have emerged in the field of pharmaceutical formulations. These pharmaceutical polymer materials are combined into preparations in different ways such as solid dispersions, microspheres, microcapsules, and pellets, or appear in common coated tablets and coated pellets to control the drug rele...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C08F220/18C08F220/06C08F220/14C08F2/26C08F2/30C08F2/38A61K47/32
Inventor 邱湘龙黄建国杨秀德方卫卫
Owner 浙江瓯伦包衣技术有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap