Preparation method and application of medicinal aqueous acrylic resin aqueous dispersion and product produced from medicinal aqueous acrylic resin aqueous dispersion

Abstract

The invention discloses a preparation method and application of a medicinal aqueous acrylic resin aqueous dispersion and a product produced from the medicinal aqueous acrylic resin aqueous dispersion. The preparation method adopts combination of a thermal decomposition initiation system and an oxidation and reduction initiation system and comprises the steps of preparing a seed latex in the thermal decomposition initiation system and the polymerizing the seed latex in the oxidation and reduction initiation system. The medicinal aqueous acrylic resin aqueous dispersion with the average size of less than 100nm, the coagulum content of less than 0.1% and the residual monomer content of less than 100ppm is prepared by adopting the preparation method. In addition, the invention further provides a product produced from the medicinal aqueous acrylic resin aqueous dispersion and application of the medicinal aqueous acrylic resin aqueous dispersion in solid medicinal preparations. The purpose of realizing low-cost industrial production can be achieved, and the situation that the production, application and popularization of the medicinal aqueous acrylic resin aqueous dispersion are limited strictly due to technology and cost factors in more than 30 years since the medicinal aqueous acrylic resin aqueous dispersion is introduced into China can be improved.

Description

technical field [0001] The invention belongs to the field of pharmaceutical polymer materials, and relates to a preparation method of a pharmaceutical acrylic resin water dispersion, the water dispersion product and its application as a polymer pharmaceutical auxiliary material in a solid pharmaceutical dosage form. Background technique [0002] Since the 1960s, a large number of polymer materials have entered the pharmaceutical field, which has promoted the application and development of polymer materials in the pharmaceutical field. In recent years, with the development of nanotechnology and material science, a large number of new preparations of nano-sized particles loaded with drugs have emerged in the field of pharmaceutical formulations. These pharmaceutical polymer materials are combined into preparations in different ways such as solid dispersions, microspheres, microcapsules, and pellets, or appear in common coated tablets and coated pellets to control the drug rele...

AI Technical Summary

Problems solved by technology

[0012] Although the above-mentioned methods are usually used in the preparation of medicinal acrylic resin aqueous dispersions, they all have the following disadvantages: the aggregate content is relatively high, generally based on 0.1%-0.5% or more of the total emulsion amount; Polymer latex with acrylic acid and its esters as monomers has a relatively coarse particle size, and the average particle size is generally 150-500nm

Due to these shortcomings, the aqueous dispersion product obtained by the preparation method has the following defects: poor film-forming properties (such as film compactness and glossiness, etc.) and emulsion wettability and penetrating power decrease due to large particle size; A higher content of condensate will significantly damage the storage stability of the aqueous dispersion product and the performance of the material; a single thermal decomposition initiation system at a higher temperature has a significant adverse effect on the polymer structure and properties of the acrylic resin, etc.

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