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Spina date seed extract and brain-strengthening and sleeping-promoting oral liquid containing spina date seed extract

The technology of jujube seed extract and oral liquid, which is applied in the field of biomedicine, can solve the problems of side effects and addiction application restrictions, and achieve the effects of no toxic side effects, increased yield, and simple and easy-to-operate preparation methods

Active Publication Date: 2015-06-03
汉方萃取生物科技(海南)股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The results of the questionnaire show that about 44% of the patients take benzodiazepines (BDZ) and barbiturates for hypnosis for a long time, but the application of these drugs is limited due to their side effects and addiction

Method used

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  • Spina date seed extract and brain-strengthening and sleeping-promoting oral liquid containing spina date seed extract
  • Spina date seed extract and brain-strengthening and sleeping-promoting oral liquid containing spina date seed extract
  • Spina date seed extract and brain-strengthening and sleeping-promoting oral liquid containing spina date seed extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] (1) Pulverize the air-dried or air-dried Chinese date kernels with a sterilized grinder to obtain Chinese date kernel powder; soak the Chinese date kernel powder in hot water at 80°C for 3 hours, and then filter to obtain filtrate 1 and filter residue 1, wherein , the filtrate 1 is stored at low temperature for subsequent use;

[0048] (2) Semi-bionic extraction: The filter residue 1 prepared in step (1) was soaked with a hydrochloric acid solution of pH 5, and filtered after 3 hours to obtain the filtrate 2 and the filter residue 2, wherein the filtrate 2 was stored at low temperature for subsequent use; the filter residue 2 was used with pH 8.2 Sodium hydroxide solution soaked for 3 hours and then filtered to obtain filtrate 3 and filter residue 3, wherein the filtrate 3 was stored at low temperature for subsequent use;

[0049] (3) Concentration: combine the filtrates 1, 2 and 3 prepared by step (1) and step (2), and concentrate by evaporation under reduced pressure ...

Embodiment 2

[0052] (1) Use a sterilized pulverizer to pulverize the air-dried or air-dried Chinese date kernels to obtain Chinese date kernel powder; soak the Chinese date kernel powder in hot water at 75°C for 4 hours, and then filter to obtain filtrate 1 and filter residue 1, wherein , the filtrate 1 is stored at low temperature for subsequent use;

[0053] (2) Semi-bionic extraction: soak the filter residue 1 prepared in step (1) with a hydrochloric acid solution of pH 1, and filter after 2 hours to obtain the filtrate 2 and the filter residue 2, wherein the filtrate 2 is stored at low temperature for later use; the filter residue 2 is hydrogenated with pH 10 Filtrate after soaking in sodium oxide solution for 2 hours to obtain filtrate 3 and filter residue 3, wherein filtrate 3 is stored at low temperature for subsequent use;

[0054](3) Concentration: combine the filtrates 1, 2 and 3 prepared by step (1) and step (2), and concentrate by evaporation under reduced pressure to obtain a ...

Embodiment 3

[0057] (1) Grinding the air-dried or air-dried spiny jujube kernels with a sterilized pulverizer to obtain spiny jujube kernel powder; soak the spiny jujube kernel powder in hot water at 78°C for 2 hours, and then filter to obtain filtrate 1 and filter residue 1, wherein , the filtrate 1 is stored at low temperature for subsequent use;

[0058] (2) Semi-bionic extraction: the filter residue 1 prepared in step (1) was soaked with a hydrochloric acid solution of pH 4, and filtered after 4 hours to obtain the filtrate 2 and the filter residue 2, wherein the filtrate 2 was stored at low temperature for subsequent use; the filter residue 2 was treated with hydrogen at pH 9 Sodium oxide solution was soaked for 4 hours and then filtered to obtain filtrate 3 and filter residue 3, wherein the filtrate 3 was stored at low temperature for subsequent use;

[0059] (3) Concentration: combine the filtrates 1, 2 and 3 prepared by step (1) and step (2), and concentrate by evaporation under re...

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Abstract

The invention belongs to the field of biological medicines, and in particular relates to a spina date seed extract and brain-strengthening and sleeping-promoting oral liquid containing the spina date seed extract. A preparation method of the spina date seed extract comprises the following steps: crushing spina date seeds, performing water extraction on active substances, performing semi-bionic extraction, concentrating, and removing impurities by using an alcohol precipitation method to obtain the spina date seed extract. The brain-strengthening and sleeping-promoting oral liquid containing the spina date seed extract is further prepared by taking the spina date seed extract as a raw material and blending with other components such as honey. The oral liquid contains sleeping-promoting and nerves-calming effective components of the spina date seeds, including spina date seed flavonoid substances, spina date seed alkaloid and jujuboside D and E, and has the effects of calming the nerves, strengthening the brain, promoting sleeping and benefiting intelligence.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to an extract of spinosa seed and a brain-invigorating and sleep-improving oral liquid containing the extract. Background technique [0002] Insomnia is the most common sleep disorder, which has great harm to human body function, intelligence and immunity. Long-term insomnia not only impairs people's thinking activities, but also affects people's immune system, which will eventually shorten the life span. Clinically, chemically synthesized drugs with sedative and hypnotic effects are commonly used to treat insomnia. The results of the questionnaire showed that about 44% of the patients took benzodiazepines (BDZ) and barbiturates for hypnosis for a long time, but the application of these drugs was limited due to their side effects and addiction. [0003] Ziziphus jujuba Mill var.spinosa Huex.H.F.Chou is the dried and mature kernel of Ziziphus jujuba Mill var.spinosa Huex.H.F....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/725A61K9/08A61P25/20A61P25/22A61K131/00
Inventor 姜建国张恬恬石嫚嫚黄小娟
Owner 汉方萃取生物科技(海南)股份有限公司
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