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Externally used emulsifiable paste for treating radiodermatitis and preparation method of emulsifiable paste

A technology for radiodermatitis and topical cream, which is applied in the directions of medical preparations containing active ingredients, skin diseases, ointment delivery, etc. Occur, increase the absorption and penetration speed of the drug, and the effect of the simple preparation method

Inactive Publication Date: 2015-06-03
祖国红
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the absorption effect of this ointment drug is poor, and the drug effect is slow; especially for radiation dermatitis above grade II when there is exudation or blisters, the treatment effect is not obvious

Method used

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  • Externally used emulsifiable paste for treating radiodermatitis and preparation method of emulsifiable paste

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037]An external cream for treating radiation dermatitis of the present invention comprises a medicine and an emulsion base, the ratio of the medicine to the emulsion base is 1:0.5; the medicine includes the following raw materials in parts by weight: 5 parts of Hedyotis diffusa, 5 parts of Angelica sinensis , 1 part of comfrey, 5 parts of skullcap, 5 parts of cnidium, 5 parts of Kochia scoparia, 5 parts of licorice, 5 parts of orange peel, and 1 part of borneol.

[0038] The emulsion base adopts the water-in-oil (W / O) type emulsion base. Due to the effect of surfactants, this type of emulsion matrix has a certain affinity for oil and water, can be mixed with wound exudate or secretion, has little effect on the normal function of the skin, and can promote the contact of the drug with the skin.

Embodiment 2

[0040] An external cream for treating radiation dermatitis of the present invention comprises a medicine and an emulsion base, the ratio of the medicine to the emulsion base is 1:3; the medicine includes the following raw materials in parts by weight: 10 parts of Hedyotis diffusa, 10 parts of Angelica sinensis , 3 parts of comfrey, 10 parts of skullcap, 10 parts of cnidium, 10 parts of Kochia scoparia, 10 parts of licorice, 10 parts of orange peel, 3 parts of borneol.

Embodiment 3

[0042] An external cream for treating radiation dermatitis of the present invention comprises a medicine and an emulsion base, the ratio of the medicine to the emulsion base is 1:0.5; the medicine includes the following raw materials in parts by weight: 5 parts of Hedyotis diffusa, 5 parts of Angelica sinensis , 1 part of comfrey, 5 parts of skullcap, 5 parts of cnidium, 5 parts of Kochia scoparia, 5 parts of licorice, 5 parts of orange peel, 1 part of borneol, 50 parts of 75% ethanol, 25 parts of olive oil, and 250 parts of water;

[0043] The emulsion type base includes the following raw materials in parts by weight: 5 parts of glyceryl monostearate, 18 parts of stearic acid, 5 parts of liquid paraffin, 1 part of Span-80, 1 part of Tween-80, 1.5 parts of triethanolamine; The emulsification temperature of the matrix is ​​80°C.

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Abstract

The invention discloses an externally used emulsifiable paste for treating radiodermatitis and a preparation method of the emulsifiable paste. The medicine can delay the occurrence time of radiodermatitis, the absorption and penetration speed of the medicine is obviously increased, and the wound anti-bacterial effect is improved; the preparation method is simple in operation and easy to popularize. According to the technical scheme, the externally used emulsifiable paste for treating radiodermatitis comprises a medicine and an emulsion base in the proportion of 1: (0.5-3), wherein the medicine comprises raw materials in parts by weight as follows: 5-10 parts of hedyotis diffusa, 5-10 parts of Chinese angelica, 1-3 parts of lithospermum erythrorhizon, 5-10 parts of radix scutellariae, 5-10 parts of cnidium monnieri, 5-10 parts of fructus kochiae scopariae, 5-10 parts of liquorice, 5-10 parts of orange peels and 1-3 parts of borneol. The preparation method comprises the steps as follows: hedyotis diffusa, Chinese angelica, radix scutellariae, cnidium monnieri, fructus kochiae scopariae, liquorice and orange peels are smashed and added with water, volatile oil and decoction are collected, and filter liquor is combined, condensed and subjected to alcohol precipitation; lithospermum erythrorhizon is immersed in olive oil; borneol is dissolved in alcohol; the medicine and the emulsion base are proportioned.

Description

technical field [0001] The invention relates to an external cream and a preparation method thereof, in particular to an external cream for treating radiation dermatitis and a preparation method thereof. Background technique [0002] Radiation therapy is a treatment method that irradiates tumors with rays of various energies to inhibit and kill cancer cells. Radiotherapy, as one of the three basic treatments for tumors, is widely used clinically. Radiation dermatitis is the most common complication of tumor radiation therapy. About 87% of radiotherapy patients will have radiation dermatitis such as erythema and wet desquamation, and the incidence of wet desquamation is 10-15%. According to data, wet desquamation occurs in about 10% of breast cancer patients at the end of radiotherapy. The prevention and treatment of radiation dermatitis has always been a concern of radiotherapy professionals. For the irradiation of superficial lesions and superficial lymphoid tissues, the i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61K9/06A61P17/16
Inventor 祖国红万烨蕾
Owner 祖国红