Purposes of polydatin in preparing anti-arrhythmic products

An anti-arrhythmia and arrhythmia technology is applied in the field of application of Polygoniside in the preparation of anti-arrhythmic products, which can solve the problems of sinus bradycardia, atrioventricular block and the like, and achieve the effect of low price

Active Publication Date: 2015-06-10
SHENZHEN UNIV
View PDF4 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antiarrhythmic drugs currently used and developed clinically can be classified into four categories according to their effects on myocardial electrophysiology and their mechanism of

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Purposes of polydatin in preparing anti-arrhythmic products
  • Purposes of polydatin in preparing anti-arrhythmic products
  • Purposes of polydatin in preparing anti-arrhythmic products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0028] 1. Materials and Methods

[0029] 1.1 Materials

[0030] 1) Reagent The polydatin used in the present invention is provided by Shenzhen Haiwang Pharmaceutical Company, and the specific method is as follows:

[0031] 100g rhizome of Polygonum cuspidatum, properly crushed, extracted by percolation with 800ml ethanol, filtered, concentrated under reduced pressure (50°C, 0.07-0.1Mpa) to a final volume of 50ml, added 100ml water, and extracted 3 times with 200ml acetic acid ethanol, the extract was decompressed Concentrate (50°C, 0.07-0.1Mpa) to 150ml, stir the polyamide powder, evaporate the solvent under reduced pressure, and use it as a loading sample for later use.

[0032] The loaded sample is loaded on a spare polyamide column (about 600ml column) by dry method, and then chromatographically eluted with 1000ml water and 3000ml30% ethanol water as the mobile phase at a flow rate of 600ml / hr, collected and washed with 30% ethanol The effluent was removed, and the fracti...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to purposes of polygonum cuspidatum extract, namely polydatin. Myocardial hypertrophy is the most important reason for triggering congestive heart failure. Ventricular hypertrophy usually involves ventricular structure change, namely ventricular remodeling. The ventricular remodeling is a complication of multiple cardiovascular diseases and a vital and decisive element in the development process of the congestive heart failure. The arrhythmia occurrence rate after the myocardial remodeling is increased by 28%, and cardiac sudden deaths caused in the end are increased by over five times. It is indicated that through in vitro study tests, the polydatin remarkably restrains heart ion channels caused by ischemia indury of mice from remodeling and has a great protective effect for arrhythmia, and therefore the polydatin can be used for preparing products resisting against arrhythmia caused by myocardial hypertrophy and/or ventricular hypertrophy. According to the method, the polydatin plays the anti-arrhythmic role by increasing the electric current density of transient outward potassium current (Ito), shortening the action potential duration (APD) of cardiac muscle cells and restraining the QT inter-phase from being prolonged.

Description

technical field [0001] The present invention relates to the clinical application of active ingredients of Chinese medicinal materials, and mainly relates to the use of a Chinese medicinal extract, piceid, polydatin, in the preparation of anti-arrhythmia products caused by cardiac hypertrophy and / or ventricular hypertrophy. Background technique [0002] 1. Arrhythmia [0003] Heart disease has become one of the fastest growing diseases in recent years. Arrhythmia is due to abnormal sinoatrial node excitation or excitation outside the sinoatrial node, the conduction of the excitation is slow, blocked or conducted through abnormal channels, that is, the origin of cardiac activity and (or) conduction disorders lead to the frequency and (or) heart beat ) abnormal rhythm. Arrhythmia is an important group of diseases in cardiovascular diseases. It can occur alone or be associated with cardiovascular disease. It can cause sudden death due to sudden onset, and it can also continu...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/7034A61P9/06
Inventor 刘杰董鸣刘文娟邓建新
Owner SHENZHEN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap