Subnormal temperature transplanted organ in vitro intelligent support system and method

Abstract

The invention discloses a sub normal temperature transplanted organ extracorporal intelligent support system and method. The system mainly comprises a sensor acquisition module, a perfusion / oxygenation module, a safety protection module, a man-machine interaction module, a data storage and analysis module, a network module, a power management module and a central control module. According to the invention, intracorporal physiological simulation of full-simulation pulsating wave perfusion, temperature control and oxygenation supply combination is constructed, and various sensors are coordinated to monitor various life indicators, so that multifunctional and multiparameter intelligent storage of an organ is realized. The method is designed according to extracorporal storage characteristics of the transplanted organ and comprises analysis of organ real-time physiological parameter, intelligent feedback adjustment and control of perfusion / oxygenation, failure alarm and safety protection, network data sharing and remote control, and safe and effective long-time storage can be realized. The system adopts the full-simulation pulsating wave perfusion and dynamic simulation feedback control technologies; the perfusion pressure is closer to that of a human body, the parameter adjustment and control are more accurate, and the range is wider.

Description

technical field [0001] The invention belongs to the field of biomedical instruments, and in particular relates to a system and method for in vitro subnormal temperature intelligent perfusion preservation of organs to be transplanted. Background technique [0002] When an organ is in vitro, it will be separated from the internal environment of a human or animal. If an appropriate living environment is not provided for it, the organ will gradually fail and die. Organ transplantation has become one of the effective measures to save the lives of patients with multiple organ failure. With the improvement of scientific research and medical treatment, the types and scope of organ transplantation have been continuously expanded, and the demand for organ transplantation has also increased sharply. According to statistics from the Ministry of Health, about 1.5 million people in China need organ transplants every year, but only 10,000 people can receive transplants every year. The ma...

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Problems solved by technology

However, under the current technical conditions, the effective time limit for the preservation of transplanted organs is relatively short. Clinically, it is difficult to preserve the isolated kidney for more than 24-30 hours, and the effective preservation time for the liver and heart is even shorter. Moreover, the preservation system is complex and huge, which is very difficult for the transportation of transplanted organs. and large-scale deployment pose great challenges

Continuous Hypothermic Perfusion (CHP) can be used to improve ischemic injury in simple cryopreservation, but since the perfusate temperature of CHP needs to be maintained at around 4°C, low temperature will inevitably lead to damage of transplanted organs

Machine perfusion at room temperature (37°C) has shown good results in animal organ transplantation, but machine perfusion at room temperature requires complex thermal perfusion units and oxygenation systems. Whether normothermic conditions are optimal or necessary for organ preservation remains debatable

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