Pretreatment ethanol extraction method of dihydroquercetin in larix gmelini wood powder

A technology for extracting dihydroquercetin and ethanol, applied in the direction of organic chemistry and the like, can solve the problems of high difficulty in operation, low production efficiency and high cost, and achieve the effects of improving purity and yield, shortening production cycle and simplifying production steps.

Inactive Publication Date: 2015-06-17
蔡兴福 +1
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  • Abstract
  • Description
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Problems solved by technology

[0008] The purpose of the present invention is to provide a pretreatment ethanol extraction method for dihydroquercetin in larch wood powder, so as to solve the problem of polyhydroxy substances such as tannins and sugars contained in larch wood powder as impurities interfering with dihydroquercetin in the prior art. The extraction of cortex directly affects the technical problems of the extraction rate and purity of dihydroquercetin; it also solves the technical problems of long production cycle, low production efficiency, and complicated operation of the process route in the prior art; it also solves the technical problems of the current hydrolysis process. There are technical problems such as easy introduction of ether, ketone or chlorine-containing solvents, high toxicity, high cost, and inconvenient continuous production

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0036]The raw material is 100g of larch wood powder with a water content of 20%, add 1L of purified water to it, stir and extract for 5 hours at room temperature, and filter out most of the water with a sieve; then add the water-soaked larch wood powder to 1L volume fraction In 95% ethanol aqueous solution, stirring and leaching with an electric stirrer at room temperature for 5 hours, and then filtering the extract with a sieve to obtain filtrate and insoluble larch wood powder; according to the above method, add 1L volume to the larch wood powder The fraction is 95% ethanol aqueous solution, stirring and leaching at room temperature for 5 hours, the extract is filtered and combined with the previous filtrate, concentrated under reduced pressure at 50°C until there is no alcohol smell, and 2.5g of extract is obtained. Suspend the concentrated extract with 0.03 L of purified water at 95°C. After the extract is basically dissolved, filter at a temperature above 60°C, filter out...

Embodiment 2

[0038] The raw material is 100g of larch wood powder with a water content of 20%, add 1L of purified water to it, stir and extract at room temperature for 5h, filter the water with a sieve, add 1L of larch wood powder with a volume fraction of 95% Ethanol aqueous solution was stirred and leached with an electric stirrer at 40°C for 3 hours to obtain the filtrate and insoluble larch wood powder; according to the above method, 1L of ethanol aqueous solution with a volume fraction of 95% was added to the larch wood powder, and stirred and leached at 40°C. After extracting for 3 hours, the extract was filtered and combined with the previous filtrate, and concentrated under reduced pressure at 50°C until there was no alcohol smell to obtain 3.5g of extract. Suspend the concentrated extract with 0.04 L of purified water at 95°C. After the extract is basically dissolved, filter at a temperature above 60°C, filter out the water-insoluble matter, let it stand still, cool to room temper...

Embodiment 3

[0040] Add 1L of purified water to 100g of larch wood powder with 20% water content, stir and extract at room temperature for 5h, and filter out the water. Add 1 L of 95% ethanol aqueous solution to the washed larch wood powder, reflux at 90°C for 4 hours, cool and filter, then concentrate under reduced pressure at 50°C until there is no alcohol smell, and 4.3g of extract is obtained. Suspend the concentrated extract with 0.05 L of purified water at 95°C. After the extract is basically dissolved, filter at a temperature above 60°C, filter out the water-insoluble matter, let it stand still, cool to room temperature, filter the precipitated out, and let it stand still until no precipitate precipitates out. All the precipitates were combined, and suspended again with 0.03 L of purified water at 95°C to obtain 1.7 g of dihydroquercetin powder. 1.7 g of the obtained dihydroquercetin was added to 6 times the amount of 20% ethanol aqueous solution, heated and dissolved, placed at ro...

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Abstract

The invention provides a pretreatment ethanol extraction method of dihydroquercetin in larix gmelini wood powder. The pretreatment ethanol extraction method comprises the following steps: with larix gmelini wood powder as a raw material, firstly pretreating the larix gmelini wood powder: leaching the larix gmelini wood powder with water, wherein the water leaching temperature is room temperature, the water leaching extraction time is 2-5 hours, and the material-water ratio is 1:5 to 1:10; then, filtering water, retaining the wet larix gmelini wood powder, adding an ethanol solution with an ethanol volume fraction of 10-95% for extracting to obtain an ethanol extracting solution, wherein the ethanol extraction method is a soaking extraction method, a reflux method or a leakage method; then concentrating and drying the ethanol extracting solution to obtain a dihydroquercetin crude product, and recrystallizing the dihydroquercetin crude product to obtain fine dihydroquercetin. The pretreatment ethanol extraction method has the main characteristics that the operation process can be directly used without drying, is economic, environmentally friendly, high in yield and suitable for industrial large-scale production, and all the solvents are recycled.

Description

technical field [0001] The invention relates to the technical field of extracting dihydroquercetin in larch wood powder, in particular to a pretreatment ethanol extraction method for dihydroquercetin in larch wood powder. Background technique [0002] Dihydroquercetin (taxifolin, dihydroquercetin), also known as Taxifolin, Taxifolin or Taxifolin, molecular formula C 15 h 12 o 7 , molecular weight 304.25, molecular structure shown in formula I. It is a dihydroflavonol compound with the chemical name 5,7,3,4-tetrahydroxydihydroflavonol. [0003] Formula I [0004] Dihydroquercetin has a strong antioxidant capacity, which can effectively eliminate excess free radicals from the human body and promote the permeability of capillaries. The antioxidant properties are superior to many existing antioxidants, and no toxicity has been reported. Therefore, it is often used as an antioxidant additive in foods such as vegetable oil, animal oil, milk powder and fat cakes. In addi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/32C07D311/40
CPCC07D311/32C07D311/40
Inventor 蔡兴福勾风云宗跟东郭庆芳张爱国蒲保岩
Owner 蔡兴福
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