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Preparation method of chitosan-based dressing with compact-loose double layer structure

A double-layer structure, chitosan technology, used in medical science, bandages, absorbent pads, etc., can solve the problems of poor moisturizing performance, difficult removal, wound adhesion, etc., and achieve low cost, good physical and chemical properties and biocompatibility The effect that is conducive to large-scale production

Inactive Publication Date: 2015-07-01
CHANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Several types of dressings that are relatively easy to see in the market include spray dressings, foam dressings, and alginate dressings, etc., but they also have many defects, such as poor strength, poor moisturizing performance, wound adhesion, and difficult removal Wait

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) prepare the chitosan solution that mass fraction is 2.5% with acetic acid, dropwise add 0.5% glutaraldehyde to carry out cross-linking as cross-linking agent, the chitosan solution after 8mL cross-linking is rapidly before gelatinization Casting into the mold, gelation molding;

[0024] (2) Prefreeze the chitosan gel obtained in step (1) at 4°C for 4 hours, then at -20°C for 12 hours, then at -80°C for 12 hours, and finally vacuum Freeze drying for more than 24 hours to obtain a chitosan scaffold material with a loose structure;

[0025] (3) The loose layer chitosan material obtained in step (2) is combined with the chitosan gel system containing cross-linking agent of 6mL to form a dense layer, and air-dried to obtain a chitosan base with a dense-loose double-layer structure dressing.

Embodiment 2

[0027] (1) prepare the chitosan solution that mass fraction is 3.0% with acetic acid, dropwise add 0.5% glutaraldehyde as cross-linking agent and carry out cross-linking, the chitosan solution after 6mL cross-linking is rapidly before gelatinization Casting into the mold, gelation molding;

[0028] (2) Prefreeze the chitosan gel obtained in step (1) at 4°C for 4 hours, then at -20°C for 12 hours, then at -80°C for 12 hours, and finally vacuum Freeze drying for more than 24 hours to obtain a chitosan scaffold material with a loose structure;

[0029] (3) The loose layer chitosan material obtained in step (2) is combined with the chitosan gel system containing cross-linking agent of 4mL to form a dense layer, and air-dried to obtain a chitosan base with a dense-loose double-layer structure dressing.

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Abstract

The invention discloses a preparation method of a chitosan-based dressing with a compact-loose double layer structure. The preparation method comprises the following steps: (1) preparing a chitosan solution with a certain concentration by acetic acid, cross linking with glutaraldehyde serving as a cross linking agent, casting a cross linked chitosan solution into a mould; (2) pre-freezing the chitosan gel obtained in the step (1) for 4h at 4 DEG C, then pre-freezing for 12h at (-20) DEG C, and then pre-freezing for 12h at (-80) DEG C, and finally vacuum freezing and drying for more than 24h, so as to obtain the chitosan material of the loose layer; and (3) bonding one side of the chitosan material of the loose layer with a certain amount of chitosan gel system containing a cross linking agent to form the compact layer, drying in air, so as to obtain the chitosan-based dressing with a compact-loose double layer structure. The material is applicable for recovering and healing of wound in medical field, the preparation process is simple and available, and the raw material is easy to get.

Description

technical field [0001] The invention provides a preparation method of a chitosan-based dressing, in particular to a chitosan-based dressing with a dense-loose double-layer structure. technical background [0002] Dressing, that is, a compress moistened with an antiseptic or antiseptic solution for the treatment of a sore or wound. Traditionally, gauze is the most commonly used dressing. The outstanding advantage of this type of dressing is that it has good water absorption, can keep the wound dry and fresh, protect the wound, is simple to make, and is cheap. It still occupies a large market in the current dressing market. huge comparison. However, gauze dressing has its shortcomings that are difficult to overcome, such as the inability to keep the wound surface moist, resulting in delayed healing of the planed surface, and the dressing fibers are easy to fall off, causing foreign body reactions and affecting healing. [0003] In addition to traditional dressings, some mode...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/44
Inventor 刘杨邓林红沈欣倪方杰
Owner CHANGZHOU UNIV
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