Iron chelation application of Trichiutus haumela bone iron-chelated collagen peptide

A technology of iron chelation and collagen peptides, which can be used in the direction of medical preparations, applications, and drug combinations containing active ingredients, and can solve the problem of wasting fishery resources.

Inactive Publication Date: 2015-07-08
ZHEJIANG OCEAN UNIV
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  • Abstract
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Problems solved by technology

However, most of the fish bones produced during hairtail processing are processed into fish bone meal or thrown away as waste, which is a waste of

Method used

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  • Iron chelation application of Trichiutus haumela bone iron-chelated collagen peptide

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Embodiment

[0019] 1) Pretreatment of hairtail fish bones: Will hairtail ( Trichiutus haumela ) fish bones were added to NaOH solution (0.1 mol / L) according to the ratio of material to liquid 1 g: 20 mL, and soaked at 2 °C for 4 h to remove non-collagen; after treatment, hairtail fish bones were repeatedly washed with distilled water until neutral, drained According to the ratio of solid to liquid 1 g: 8 mL, add EDTA solution (0.5 mol / L) with pH 7.4, soak at 3°C ​​for 3 days (replace the EDTA solution once a day), wash with distilled water 3 times, dry and pulverize to obtain Calcium hairtail fish bone meal.

[0020] 2) Preparation of hairtail fish bone collagen: The decalcified hairtail fish bone meal was added to 0.5 mol / L acetic acid solution according to the ratio of solid to liquid 1 g:8 mL and dynamically soaked at 4 °C for 3 days, 10 000 g Centrifuge for 25 min, take the supernatant, add NaCl to the final concentration of 1.0 mol / L, let stand for 90 min, 12 000 g Centrifuge f...

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Abstract

The invention relates to iron chelation application of Trichiutus haumela bone iron-chelated collagen peptide. Owing to a unique chelation and transport mechanism, the iron-chelated collagen peptide is high in absorption and utilization degree, also can supplement polypeptide/amino acid and iron and is an ideal iron supplement substance. According to the iron-chelated collagen peptide, Trichiutus haumela bone is taken as a raw material, collagen is extracted by an acid process and is enzymatically hydrolyzed by compound flavourzyme and neutral protease, and separation and purification are performed by ultrafiltration, immobilized iron ion affinity chromatography and reversed-phase high-performance liquid chromatography to obtain the iron-chelated collagen peptide Gly-Pro-Pro-Gly-Pro-Trp-Gly-Pro-His-Gly, and the molecular weight based on ESI/MS detection is 957.99Da.

Description

technical field [0001] The invention belongs to the product application field of deep processing technology of aquatic products, and in particular relates to an iron chelation application of hairtail fish bone iron chelation collagen peptide. Background technique [0002] Collagen peptide is a hydrolyzate with an average molecular weight of about 1 000 Da prepared from collagen by enzymatic cleavage technology. Compared with the complex three-level superhelical structure of collagen, the linear structure of collagen peptide allows it to be absorbed by the human body without decomposition Utilization, the digestion and absorption rate is as high as 80%. Compared with macromolecular substances such as collagen, collagen peptides can effectively penetrate into the dermis, prolong the lifespan of skin cells, resist the attack of free radicals on DNA, inhibit cell membrane lipid peroxidation, promote the synthesis of collagen and hyaluronic acid, and improve skin immunity It h...

Claims

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Application Information

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IPC IPC(8): A61K38/39A61K33/26A61P7/06A61P3/02A23L1/304A23L1/305
Inventor 王斌迟长凤邓尚贵孙坤来
Owner ZHEJIANG OCEAN UNIV
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