Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A synthetic method of N-cyanomethyl-4-(trifluoromethyl)nicotinamide

The technology of a trifluoromethyl group and a synthetic method, applied in the field of pesticides, can solve the problems of high production safety risks and the like, and achieve the effects of convenient operation, simple process and good yield

Active Publication Date: 2015-07-08
WUXI JIABAO PESTICIDE & PHARMA
View PDF1 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, highly toxic phosgene is required, which poses a high production safety risk

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A synthetic method of N-cyanomethyl-4-(trifluoromethyl)nicotinamide
  • A synthetic method of N-cyanomethyl-4-(trifluoromethyl)nicotinamide
  • A synthetic method of N-cyanomethyl-4-(trifluoromethyl)nicotinamide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] After adding 19g (0.1mol) of 4-(trifluoromethyl)nicotinamide, 12.72g (0.12mol) of sodium carbonate and 80g of dimethylformamide in a 250mL reactor with a reflux condenser, at 15± 8.25 g (0.11 mol) of chloroacetonitrile was added dropwise with stirring at 5°C, and then the reaction temperature was raised to 80°C for 8 hours.

[0028] After the reaction, the liquid layer was analyzed by liquid chromatography, and the result was that the yield (selectivity) of N-cyanomethyl-4-(trifluoromethyl)nicotinamide was 96.8%, and 4-(trifluoromethyl) ) The conversion rate of nicotinamide is 98.9%, and the yield is selectivity, which is the converted yield without separation and purification.

Embodiment 2

[0030] After adding 19g (0.1mol) of 4-(trifluoromethyl)nicotinamide, 15.9g (0.15mol) of sodium carbonate and 100g of dimethylformamide in a 250mL reactor with a reflux condenser, at 15± 8.25 g (0.11 mol) of chloroacetonitrile was added dropwise with stirring at 5°C, and then the reaction temperature was raised to 80°C for 8 hours.

[0031] After the reaction, the liquid layer was analyzed by liquid chromatography, and the result was that the yield (selectivity) of N-cyanomethyl-4-(trifluoromethyl)nicotinamide was 96.5%, and 4-(trifluoromethyl) ) The conversion rate of nicotinamide is 98.6%, and the yield is selectivity, which is the converted yield without separation and purification.

Embodiment 3

[0033] After adding 19g (0.1mol) of 4-(trifluoromethyl)nicotinamide, 15.9g (0.15mol) of sodium carbonate and 100g of dimethylformamide in a 250mL reactor with a reflux condenser, at 15± 11.25 g (0.15 mol) of chloroacetonitrile was added dropwise with stirring at 5°C, and then the reaction temperature was raised to 80°C for 8 hours.

[0034] After the reaction, the liquid layer was analyzed by liquid chromatography, and the result was that the yield (selectivity) of N-cyanomethyl-4-(trifluoromethyl)nicotinamide was 96.2%, and 4-(trifluoromethyl) ) The conversion rate of nicotinamide is 98.1%, and the yield is selectivity, which is the converted yield without separation and purification.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A synthetic method of N-cyanomethyl-4-(trifluoromethyl)nicotinamide is disclosed. 4-(trifluoromethyl)nicotinamide and chloroacetonitrile are adopted as raw materials, and are synthesized into the N-cyanomethyl-4-(trifluoromethyl)nicotinamide under the existence of an acid-binding agent by one step. The chemical equation is shown in the specification. The method achieves synthesis in one step, and is high in conversion rate (not less than 98%), high in yield (not less than 95%), simple in process, convenient in operation and prone to industrial production.

Description

technical field [0001] The invention relates to the field of pesticides, in particular to a synthesis method of N-cyanomethyl-4-(trifluoromethyl)nicotinamide. Background technique [0002] N-cyanomethyl-4-(trifluoromethyl)nicotinamide, English common name: flonicamid, Chinese common name: flonicamid. N-cyanomethyl-4-(trifluoromethyl)nicotinamide is a new type of low-toxicity pyridine amide insect growth regulator insecticide. In 2007, it obtained the temporary registration certificate of my country's agricultural and national pesticide products. The preparation is 10% Water dispersible granules. N-cyanomethyl-4-(trifluoromethyl)nicotinamide is effective against various piercing-sucking mouthparts pests and has good penetration. It can penetrate from roots to stems and leaves, but the penetration from leaves to stems and roots is relatively weak. The agent works by hindering the sucking action of pests. The pests stop sucking soon after ingesting the potion, and finally di...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D213/82
CPCC07D213/82
Inventor 刘正勇王祥荣冷云芬王瑞初吴璇丁同富
Owner WUXI JIABAO PESTICIDE & PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com