Method for preparing azlocillin sodium for injection and facilitating rejection of non-confirming products

A technology of azlocillin sodium and qualified products, which is applied in the field of preparation of azlocillin sodium for injection, can solve the problems of unqualified azlocillin sodium finished products, and achieve the effects of avoiding unlabeled, improving efficiency, and speeding up the mixing speed

Inactive Publication Date: 2015-07-08
SICHUAN PHARMA
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  • Abstract
  • Description
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Problems solved by technology

[0006] The technical problem to be solved by this invention is to provide a kind of preparation method of azlocillin sodium for injection that is convenient to reject unqualified pr

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  • Method for preparing azlocillin sodium for injection and facilitating rejection of non-confirming products

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Embodiment

[0022] like figure 1 Shown, the preparation method of the azlocillin sodium for injection that is convenient to reject unqualified product may further comprise the steps:

[0023] (1) Synthesis of azlocillin sodium: Mix dichloromethane and ampicillin at a weight ratio of 1:0.065, adjust the pH of the solution to be alkaline, obtain a condensation reaction solution, and mix 1-chloroformyl-2 - Imidazolidinone and dichloromethane are put into the above condensation reaction solution, and the weight ratio of 1-chloroformyl-2-imidazolidinone, dichloromethane and condensation reaction solution is 1:4.6:28.5; the pH of the adjustment solution is weak Alkaline, continue to stir to get the condensation reaction material, use water to extract and separate the above condensation reaction material one by one, transfer the water layer to the crystallization tank, adjust the pH with acid, centrifuge the crystals after crystallization, wash and dry the crystals Azlocillin, the azlocillin is...

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Abstract

The invention relates to a method for preparing azlocillin sodium for injection and facilitating rejection of non-confirming products. The method comprises the steps of firstly synthesizing azlocillin sodium, grinding and preparing, wherein the preparation process is as follows: cleaning a reagent bottle for containing azlocillin sodium powder, then quantificationally putting the azlocillin sodium powder into the cleaned reagent bottle by specification, filling the reagent bottle containing the azlocillin sodium powder with nitrogen, then covering the reagent bottle with a preprocessed rubber plug, fastening an aluminium cap so as to seal the product, sequentially labeling an internal label on the reagent bottle with the fastened cap, packaging and carrying out lamp examination, finally labeling an external label on a packaging box, inspecting and packing. According to the method, a weighing machine, a full-load channel switch and a non-load channel switch are arranged at an output end of a conveyor belt in a preparation process so that the problem of idle load of the reagent bottle is avoided; and an automatic camera, an untagged channel switch and a qualified product channel switch are arranged on the full-load channel so that the problem of missing of labeling of the reagent bottle is avoided.

Description

technical field [0001] The invention relates to the field of preparation methods of medical drugs, in particular to a preparation method of azlocillin sodium for injection which is convenient for rejecting unqualified products. Background technique [0002] Azlocillin sodium, its chemical name is: (2S,5R,6R)-3,3-Dimethyl-6-[(R)-2-(2-oxo-1-imidazolidinecarboxamido)- 2-benzacetylamino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt. [0003] Azlocillin sodium was first developed by Bayer Company of Germany. It went on the market in May 1977. Since the 1980s, it has been used in the United States, Britain and other countries. In 1983, it was included in the supplementary volume of the 20th edition of the US Pharmacopoeia. However, it is recorded that its bactericidal effect on Pseudomonas aeruginosa is about ten times greater than that of carbenicillin, and it also has the effect of ampicillin on Gram-positive bacteria, and it retains the activity of car...

Claims

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Application Information

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IPC IPC(8): C07D499/68C07D499/16
CPCC07D499/68C07D499/16
Inventor 刘萍王强张静文
Owner SICHUAN PHARMA
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