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Preparation process for injection ceftiofur sodium with unqualified products convenient to eliminate

A technology of ceftiofur sodium and preparation process, applied in the field of medicine, can solve problems such as unqualified finished products of ceftiofur sodium, and achieve the effects of avoiding unlabeled, suitable for industrial production and mild reaction conditions

Inactive Publication Date: 2016-03-09
CHINA CHENGDU ANIMAL HUSBANDRY IND BIOPHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by this invention is to provide a kind of preparation technology of ceftiofur sodium for injection that is convenient to reject unqualified products, to overcome the finished product of ceftiofur sodium for injection easily caused by the existing ceftiofur sodium preparation in the preparation process unqualified problem

Method used

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  • Preparation process for injection ceftiofur sodium with unqualified products convenient to eliminate

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Such as figure 1 Shown, the preparation technology of the ceftiofur sodium for injection that is convenient to reject unqualified product comprises the following steps:

[0025] 1) Synthesis of ceftiofur sodium: use 7-aminocephalosporanic acid as the raw material, use tetrahydrofuran and purified water as the solvent in a ratio of 1:3, and obtain the triethylamine salt of ceftiofur after reaction, and then in tetrahydrofuran After reacting with sodium isooctanoate, the precipitate of ceftiofur sodium is obtained, the ratio of tetrahydrofuran to sodium isooctanoate is 2:1, the precipitate is washed with ethanol, and the wet product of ceftiofur sodium is obtained after filtration under reduced pressure;

[0026] 2), drying and grinding the prepared ceftiofur sodium wet product into powder;

[0027] 3) The preparation process of ceftiofur sodium: first clean the reagent bottle used to hold the ceftiofur sodium powder, then quantitatively fill the ceftiofur sodium powder ...

Embodiment 2

[0029] Such as figure 1 Shown, the preparation technology of the ceftiofur sodium for injection that is convenient to reject unqualified product comprises the following steps:

[0030] 1) Synthesis of ceftiofur sodium: 7-aminocephalosporanic acid is used as raw material, tetrahydrofuran and purified water are used as solvents in a ratio of 1:4, and the triethylamine salt of ceftiofur is obtained through reaction, and then in tetrahydrofuran After reacting with sodium isooctanoate, the precipitate of ceftiofur sodium is obtained, the ratio of tetrahydrofuran to sodium isooctanoate is 3:1, the precipitate is washed with n-propanol, and the wet product of ceftiofur sodium is obtained after filtration under reduced pressure;

[0031] 2), drying and grinding the prepared ceftiofur sodium wet product into powder;

[0032] 3) The preparation process of ceftiofur sodium: first clean the reagent bottle used to hold the ceftiofur sodium powder, then quantitatively fill the ceftiofur sodi...

Embodiment 3

[0034] Such as figure 1 Shown, the preparation technology of the ceftiofur sodium for injection that is convenient to reject unqualified product comprises the following steps:

[0035] 1) Synthesis of ceftiofur sodium: use 7-aminocephalosporanic acid as the raw material, use tetrahydrofuran and purified water as the solvent in a ratio of 1:5, react to obtain the triethylamine salt of ceftiofur, and then dissolve it in methanol After reacting with sodium 2-ethylhexanoate, the precipitate of ceftiofur sodium is obtained, the ratio of methanol to sodium isooctanoate is 2:1, the precipitate is washed with ethylene glycol, and then filtered under reduced pressure to obtain the wet product of ceftiofur sodium;

[0036] 2), drying and grinding the prepared ceftiofur sodium wet product into powder;

[0037] 3) The preparation process of ceftiofur sodium: first clean the reagent bottle used to hold the ceftiofur sodium powder, then quantitatively fill the ceftiofur sodium powder into ...

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Abstract

The invention relates to a preparation process for injection ceftiofur sodium with unqualified products convenient to eliminate. The preparation process for the ceftiofur sodium includes the following steps that wet ceftiofur sodium products are prepared; the prepared wet ceftiofur sodium products are dried and ground into powder; The preparation process for the ceftiofur sodium includes: reagent bottles used for containing the ceftiofur sodium powder are washed, the ceftiofur sodium powder is quantitatively put into the cleaned reagent bottles according to the specification, the reagent bottles are filled with nitrogen, the reagent bottles are covered with pretreated rubber plugs and sealed by aluminum caps, the products are sealed, the reagent bottles sealed through the caps are sequentially pasted with inner labels, packaged and checked through lamplight, packaging boxes are pasted with outer labels, and checking and packaging are performed. By the adoption of the process, the problem that the finished injection ceftiofur sodium products are unqualified due to a preparation process of ceftiofur sodium is solved.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a preparation process of ceftiofur sodium for injection which is convenient for rejecting unqualified products. Background technique [0002] With the development of modern animal husbandry, the long-term abuse of antibiotics in the past has caused more and more drug resistance and drug residues in many bacteria, which has attracted more and more attention. In particular, the large-scale outbreak of bird flu in recent years has caused the entire pharmaceutical industry to think deeply about medication. [0003] Ceftiofur sodium chemical name: [6R-[6α,7β(Z)]]-7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[ (2-Furancarbonyl)thio]methyl]-8oxo-5-thia-1-aminobicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt, the product is white to grayish yellow Powder, this product is a compound preparation for sterilization, anti-inflammation, antipyretic and analgesia. Ceftiofur s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B65B65/00B65B57/00B65G43/08B07C5/28C07D501/36C07D501/04A61K31/546A61P31/04
CPCB65B65/003A61K31/546B07C5/28B65B57/00B65G43/08B65G2203/0258C07D501/04C07D501/36
Inventor 廖成斌卢朝成
Owner CHINA CHENGDU ANIMAL HUSBANDRY IND BIOPHARM
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