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Product qualified rate improving preparation method for cefuroxime sodium for injection

A technology for cefuroxime sodium and product qualification rate, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, and organic active ingredients, etc. Unlabeled effects

Inactive Publication Date: 2015-08-19
SICHUAN PHARMA
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0006] The technical problem to be solved by this invention is to provide a kind of preparation method of the cefuroxime sodium for injection that improves the qualified rate of the product, to overcome the production process of the existing cefoxitin sodium injection that is easy to cause the product failure due to more unqualified products The problem of reduced quality

Method used

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  • Product qualified rate improving preparation method for cefuroxime sodium for injection

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Embodiment

[0022] Such as figure 1 Shown, the preparation method of the cefuroxime sodium for injection that improves product qualified rate comprises the following steps:

[0023] (1), the synthesis of cefuroxime sodium: add absolute ethanol or methanol,

[0024] Sodium lactate aqueous solution and sodium isooctanoate are stirred until sodium isooctanoate is completely dissolved, and the dissolution temperature is set at 30°C to obtain a sodium solution, wherein, in the sodium solution, the molar ratio of sodium isooctanoate and sodium lactate is 2:7, and the other Add acetone, water and cefuroxime acid into the container, stir to dissolve cefuroxime acid completely, add activated carbon, stir to decolorize, filter to obtain cefuroxime acid filtrate, add cefuroxime acid filtrate to the sodium solution, the amount of sodium solution is greater than that of cefuroxime The amount of caprylic acid filtrate, stir, produce precipitation, filter, obtain cefuroxime sodium wet product;

[0025...

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Abstract

The invention relates to a product qualified rate improving preparation method for cefuroxime sodium for injection. The method includes the steps of: first synthesis of cefoxitin sodium into a wet product, then powdering of cefoxitin sodium, and then preparation process, which includes: firstly cleaning a reagent bottle for holding cefoxitin sodium, then loading the cefoxitin sodium powder into the cleaned reagent bottle quantitatively according to specifications, filling the cefoxitin sodium powder filled reagent bottle with nitrogen, covering the reagent bottle with a pretreated rubber plug, then carrying out aluminum cover tying treatment to seal the product, subjecting the tied reagent bottle to inner label pasting, packaging and lamp inspection in order, then pasting an outer label on the packaging box, and then conducting inspection and packing. With the method provided by the invention, the product quality reduction problem caused by a lot of unqualified products in existing injection cefoxitin sodium preparation technologies can be overcome.

Description

technical field [0001] The invention relates to the field of preparation methods of medical drugs, in particular to a preparation method of cefuroxime sodium for injection which improves the qualified rate of products. Background technique [0002] Cefuroxime sodium, chemical name (6R,7R)-7-[2-furyl(methoxyimino)acetamido]-3-carbamoyloxymethyl-8-oxo-5-thia- 1-Azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt. [0003] Cefuroxime sodium is a second-generation cephalosporin antibiotic, and its antibacterial activity against Gram-positive cocci is similar or slightly worse than that of the first-generation cephalosporins, but its β-lactamase against Staphylococcus and Gram-negative bacilli is comparable Stablize. Methicillin-resistant Staphylococcus, Enterococcus and Listeria are drug-resistant, and other positive cocci are sensitive to this product. It can be used for pneumonia caused by sensitive bacteria and other lower respiratory tract infections, urinary tract i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K31/546C07D501/04C07D501/34A61P31/04
Inventor 陈继源包莹刘萍
Owner SICHUAN PHARMA
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