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Preparation method for counting device equipped ceftriaxone sodium for injection

A technology of ceftriaxone sodium and a counting device, which is applied in the fields of medical preparations containing active ingredients, organic chemistry, pharmaceutical formulations, etc., can solve the problems of inability to control products, and cannot monitor the preparation process, so as to increase the service life and avoid future failures. The effect of labeling

Inactive Publication Date: 2015-08-19
SICHUAN PHARMA
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  • Claims
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Problems solved by technology

[0006] The technical problem to be solved by this invention is to provide a kind of preparation method of ceftriaxone sodium for injection with counting device, to overcome the existing preparation process of injection ceftriaxone sodium can not monitor the preparation process in real time, can not monitor the product The problem of effective management and control

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  • Preparation method for counting device equipped ceftriaxone sodium for injection

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Embodiment

[0024] like figure 1 Shown, the preparation method of the ceftriaxone sodium for injection with counting device may further comprise the steps:

[0025] (1) Synthesis of ceftriaxone sodium: 7-aminocephalosporanic acid and triazine acid are reacted in dimethyl carbonate to generate 7-ACT, and then 7-ACT and AE-active ester are mixed in ethanol and water Synthesize ceftriaxone sodium wet product in the element system;

[0026] (2) Freeze-drying the synthesized wet product of ceftriaxone sodium and pulverizing it into powder and sieving;

[0027] (3) The preparation process of ceftriaxone sodium: firstly, the reagent bottle used to hold ceftriaxone sodium powder is cleaned, and the cleaning process of the reagent bottle is ultrasonic washing, 80°C-100°C

[0028] Soak in hot water for 30min-60min, then rinse with warm water at 25°C, air dry, oven dry, and sterilize, then fill the ceftriaxone sodium powder quantitatively into the above-mentioned cleaned reagent bottle according t...

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Abstract

The invention relates to a preparation method for counting device equipped ceftriaxone sodium for injection. The method includes the steps of: ceftriaxone sodium synthesis, crushing and preparation. The preparation process includes: cleaning a reagent bottle for holding ceftriaxone sodium powder, then loading the ceftriaxone sodium powder into the cleaned reagent bottle quantitatively according to specifications, then filling the ceftriaxone sodium powder loaded reagent bottle with nitrogen, then covering the bottle with a pretreated rubber plug, then carrying out aluminum cover tying treatment to seal the product, subjecting the tied reagent bottle to inner label pasting, packaging and lamp inspection in order, then pasting an outer label on the packaging box, and then conducting inspection and packing. In the preparation process of the invention, by disposing a weighing machine, a full load channel switch, and a no-load channel switch at the output end of a conveyor belt, the reagent bottle idle load problem is avoided, and through arrangement of a counter, the problem that product production cannot be controlled in real time is avoided.

Description

technical field [0001] The invention relates to the field of preparation methods of medical drugs, in particular to a preparation method of ceftriaxone sodium for injection with a counting device. Background technique [0002] Ceftriaxone sodium, chemical name (6R,7R)-7-[(Z)-2-amino-4thiazolyl-2-methoxyiminoacetamido]-8-oxo-5-sulfur-1-nitrogen Hetero[4,2,0]-oct-2-ene-2-carboxylic acid disodium salt. [0003] Ceftriaxone sodium is a long-acting antibiotic drug among the third-generation cephalosporins. It has a bactericidal effect on many Gram-positive bacteria, negative bacteria and anaerobic bacteria, and it has a bactericidal effect on most of the β-lactams produced by bacteria. The enzyme is highly stable, which enhances its antibacterial effect. Clinically, it is widely used in respiratory tract infection and urinary system infection sensitive to this product, including nephritis and gonorrhea, meningitis, burn infection, postoperative infection, bone joint, soft tissu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K31/546C07D501/06C07D501/36A61P31/04
Inventor 刘萍王强张静文
Owner SICHUAN PHARMA
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