Traditional Chinese medicine composition and application thereof

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition, can solve problems such as unclear local and systemic effects, improper use by patients, and poor performance, so as to prevent and treat pulmonary angiogenesis and remodeling, reduce airway remodeling, and improve The effect of physique

Inactive Publication Date: 2015-07-22
ZHEJIANG PROVINCIAL HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although inhalation preparations have been developed to a large extent, different types of drugs and dosages can be selected to meet the needs of patients with different degrees of disease, but some patients use them improperly, and the local and systemic effects of some preparations after long-term use are still unclear , and it

Method used

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  • Traditional Chinese medicine composition and application thereof
  • Traditional Chinese medicine composition and application thereof
  • Traditional Chinese medicine composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Raw material formula of traditional Chinese medicine: Astragalus 30g, Codonopsis 30g, Rehmannia glutinosa 15g, Angelica 12g, Ophiopogon japonicus 12g, Xianlingpi 10g, Salvia miltiorrhiza 15g, Guangdilong 15g, Campanulaceae 10g, licorice 6g.

[0023] (2) Extract: Submerge the prescribed amount of traditional Chinese medicine raw materials in water, immerse at room temperature for 0.5-1 hour, decoct twice for 1 hour each time, combine the two decoctions, filter, and concentrate the filtrate to a relative density of 1.08-1.12 After cooling, add absolute ethanol until the volume content of ethanol is 60%, stir fully, refrigerate and stand at 4°C for more than 12 hours until precipitation occurs, take the supernatant of alcohol precipitation, filter, and recover ethanol from the filtrate under reduced pressure, continue to concentrate to relative density It is 1.34~1.40, and the extract of Baofei Dingchuan Decoction is obtained.

Embodiment 2

[0024] Example 2: Experimental research on antitussive, expectorant and anti-inflammatory effects

[0025] 1. Experimental method:

[0026] 1. Grouping and administration:

[0027] Choose 50 ICR mice, be randomly divided into 5 groups (high-dose group, middle-dose group, low-dose group, control group and blank group), each group has 10: large, medium and low-dose groups are given the method of embodiment 1 respectively The prepared extract 16g / kg, 8g / kg, 4g / kg was administered orally qd; the control group was given Guilong Kechuanning Capsules (purchased from Huadong Medicine Co., Ltd.) 1.3g / kg orally qd; the blank group was given normal saline 2g / kg gavage qd.

[0028] 2. Test content:

[0029] (1) Antitussive test in mice: 3 days before the test, the mice were administered 3 days after the last administration, and the mice were placed in a glass bell jar half an hour after the last administration, and 25 % ammonia water was evenly sprayed into the bell jar, stopped after...

Embodiment 3

[0047] Embodiment 3: the influence on the pathology of emphysema rats

[0048] 1. Materials and methods

[0049] 1. Modeling:

[0050] Two-factor stimulus modeling was used. Rats were placed in a fixed wooden box and given 200ppm SO 2 Gas quantitative stimulation, 3min / d, for a total of 15 days, resulting in chronic bronchitis model. Then the rats were placed in a glass bell jar connected with an ultrasonic nebulizer, and 10 ml of 0.5% papain solution (diluted in normal saline) was sprayed into the bell jar through an atomizing tube, once every other day, 5 times in total. The observation was continued after the stimulation was stopped, and the rats were killed on the 50th day.

[0051] 2. Grouping and administration:

[0052] Take 60 healthy SD rats, weighing 180±20g, half male and half male. They were randomly divided into six groups, namely healthy group, model group, Baofei Dingchuan Decoction high, medium and low dose groups, Guilong Kechuanning group, 10 rats in ea...

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Abstract

The invention discloses a traditional Chinese medicine composition and application thereof in the preparation of a drug for treating chronic obstructive pulmonary disease. The traditional Chinese medicine composition is prepared from the following raw materials in part by weight: 1 part of herba epimedii, 1-5 parts of radix codonopsitis, 1-5 parts of radix astragali, 1-5 parts of radix salviae miltiorrhizae, 1-5 parts of radix angelicae sinensis, 1-5 parts of radix rehmanniae preparata, 1-5 parts of radix ophiopogonis, 1-5 parts of pheretima aspergillum, 1-5 parts of radix platycodi and 1-5 parts of radix glycyrrhizae. According to the invention, the traditional Chinese medicine composition can effectively prevent pulmonary angiogenesis and remodeling and effectively reduce airway remodeling; the long-term clinical experience proves that the traditional Chinese medicine composition has good effects of preventing cough, eliminating phlegm, resisting inflammation, preventing emphysema and pulmonary heart disease, improving physical fitness and quality of life, and has no throat discomfort, hoarseness, oropharyngeal candidiasis, rash, contact dermatitis and other side effects.

Description

(1) Technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating chronic obstructive pulmonary disease and its application. (2) Background technology [0002] Chronic Obstructive Pulmonary Disease (COPD) is a common and frequently-occurring disease among middle-aged and elderly people. Due to its high mortality rate and heavy social and economic burden, it has become the fourth leading cause of death in humans after cardiovascular diseases, tumors, and strokes. reason, is expected to rise to third place by 2020. [0003] According to modern medicine, COPD is a lung disease with persistent airflow limitation and progressive development. Its main pathological basis is the remodeling of small airways. Most views believe that the remodeling of small airways is closely related to repeated stimulation of chronic inflammation. The main pathological changes are damage to respir...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61P11/00A61K35/62
Inventor 王会仍骆仙芳陈芳
Owner ZHEJIANG PROVINCIAL HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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