Medicinal preparation for treating arthralgia, and preparation method thereof
A technology for pharmaceutical preparations and joint pain, which is applied in the field of pharmaceutical preparations for the treatment of joint pain and its preparation. It can solve the problems of complex extract components, poor storage stability of preparations, and easy oxidation and deterioration, so as to achieve high effective active ingredients of drugs and clinical application. Safe and avoid oxidative deterioration
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Embodiment 1
[0018] Embodiment 1: the preparation of Jingulian tablet
[0019] 1) Take 170g of dried Tou Gu Xiang and crush it, pass through a 0.9mm sieve, add 8 times the amount of 60% ethanol to soak for 2 hours, ultrasonically extract for 1 hour, filter, recover ethanol from the medicinal solution under reduced pressure, and dry under reduced pressure to obtain Tou Gu Xiang Extract and dregs for later use;
[0020] 2) Weigh 600ml of warm water at 50-60°C in an insulated barrel, then weigh 40g of sulfobutyl-β-cyclodextrin in a stainless steel stirring incubator, stir to melt the cyclodextrin, and dissolve the prepared product in step 1) The extract is poured into the insulation barrel through the funnel of the insulation barrel for mixing and stirring. The inclusion temperature is kept at 38°C, stirred for 45 minutes, cooled and left for 12 hours, suction filtered, and vacuum-dried at 40°C for 4 hours to obtain the drug-containing inclusion compound ;
[0021] 3) Weigh 25g of Jintiesuo...
Embodiment 2
[0024] Embodiment 2: the preparation of Jingulian capsule
[0025] 1) Take 343g of dried Tou Gu Xiang and crush it, pass through a 0.9mm sieve, add 8 times the amount of 60% ethanol to soak for 2 hours, ultrasonically extract for 1 hour, filter, recover ethanol from the medicinal solution under reduced pressure, and dry under reduced pressure to obtain Tou Gu Xiang Extract and dregs for later use;
[0026] 2) Weigh 600ml of warm water at 50-60°C in an insulated barrel, then weigh 60g of sulfobutyl-β-cyclodextrin in a stainless steel stirring incubator, stir to melt the cyclodextrin, and extract the extract prepared in step (1) The compound was poured into the heat preservation barrel through the funnel of the heat preservation barrel for mixing and stirring, the inclusion temperature was kept at 38°C, stirred for 45 minutes, cooled and left for 12 hours, suction filtered, and vacuum dried at 40°C for 4 hours to obtain the drug-containing inclusion compound;
[0027] 3) Weigh ...
Embodiment 3
[0030] Embodiment 3, the preparation of Jingulian dropping pill
[0031] 1) Take 500g of dried Tou Gu Xiang and crush it, pass through a 0.9mm sieve, add 8 times the amount of 60% ethanol to soak for 2 hours, ultrasonically extract for 1 hour, filter, recover ethanol from the medicinal solution under reduced pressure, and dry under reduced pressure to obtain Tou Gu Xiang Extract and dregs for later use;
[0032] 2) Weigh 600ml of warm water at 50-60°C in an insulated barrel, then weigh 80g of sulfobutyl-β-cyclodextrin in a stainless steel stirring incubator, stir to melt the cyclodextrin, and put the prepared product in step (1) The extract is poured into the insulation barrel through the funnel of the insulation barrel for mixing and stirring. The inclusion temperature is kept at 38°C, stirred for 45 minutes, cooled and left for 12 hours, suction filtered, and vacuum-dried at 40°C for 4 hours to obtain the drug-containing inclusion compound ;
[0033] 3) Weigh 75g of Jintie...
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