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Multifunctional mitomycin-containing cotton sheet for stopping bleeding and avoiding adhesion

A mitomycin, multi-functional technology, applied in blood diseases, medical preparations containing active ingredients, medical science, etc., can solve the problem of not inhibiting the hypertrophic scar adhesion of surrounding fibroblasts, unable to achieve accurate hemostasis, waste of goods, etc. problems, to avoid scar hyperplasia, save operation time, clear and effective hemostasis

Active Publication Date: 2015-08-12
南京双健医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to aim at the various operations of ophthalmology, otolaryngology head and neck surgery, plastic surgery, obstetrics and gynecology, orthopedics, stomatology and urology, etc., which cannot achieve accurate hemostasis with cotton pads, and mostly cover oppression with a large area. It is easy to leave gaps to cause hematoma formation, or the hemostatic area needs to be cut to cause waste of goods; at the same time, the cotton pad has only hemostatic effect, and has no effect on inhibiting the proliferation of surrounding fibroblasts and preventing scar adhesion; The prime C method has the disadvantages of ready-to-use and ready-to-use, cumbersome steps, time-wasting, and easy contamination. A multi-functional hemostatic and anti-adhesion cotton sheet containing mitomycin that is easy to use and has anti-scar, adhesion, and postoperative infection is provided.

Method used

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  • Multifunctional mitomycin-containing cotton sheet for stopping bleeding and avoiding adhesion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1: mitomycin C and asiaticoside cotton sheets for preventing cicatrix adhesion, using medical cotton sheets as a carrier, soaking the medical cotton sheets in a certain concentration of mitomycin C solution and asiaticoside solution and then drying, A cotton sheet uniformly adhered with mitomycin C and asiaticoside was obtained. The specific production method is:

[0027] Take an uncut cotton piece of 100cm×100cm as an example:

[0028] Weigh 100g of mitomycin C, dissolve it in a 100cm×100cm×20cm container containing 100L, mix well, prepare a 1mg / ml solution, and freeze it at -20°C. Prepare 0.4mg / ml mitomycin C solution, pour it into a 100L 100cm×100cm×20cm container, completely immerse 10 pieces of 100cm×100cm cotton pieces in it, soak for 5min, mix well, degas, weigh 3.0g Add an appropriate amount of asiaticosides to water, stir for 10 minutes, add water to 100ml after dissolving, stir for 30 minutes, put the cotton slices into the asiaticoside solution for ...

Embodiment 2

[0029] Embodiment 2: The cotton sheet was made according to the same method as in Embodiment 1, except that 0.3 mg / ml mitomycin C solution was used.

Embodiment 3

[0030] Example 3: A cotton sheet was made according to the same method as in Example 1, except that 0.5 mg / ml mitomycin C solution was used.

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Abstract

The invention discloses a multifunctional mitomycin-containing cotton sheet for stopping bleeding and avoiding adhesion, which is designed according to the adhesion generating mechanism (namely local hematoma formation and fibroblast hyperplasia). The multifunctional mitomycin-containing cotton sheet has the effects of locally and precisely stopping bleeding, preventing hematoma formation and inhibiting peripheral fibroblast hyperplasia and locally and precisely preventing adhesion of scar tissues, and is a unique anti-adhesion product which is not needed to be embedded into a body in the current anti-adhesion products. The cotton sheet is a bleeding stopping tool which is most frequently used and is more effective in an operation; the cotton sheet has the advantages of disposability, capability of using after taking, convenience and rapidness as well as remarkable bleeding stopping effect and the like; the requirements for the size specifications of cotton sheets are different according to different operations, and the cotton sheets with different size specifications for meeting different operation requirements are designed, so that the aims of precisely stopping bleeding, avoiding wastes and avoiding hematoma formation are achieved; and mitomycin with a certain concentration and asiaticoside with a certain concentration are uniformly distributed in the cotton sheet disclosed by the invention, so that the cotton sheet has the effects of inhibiting fibroblast hyperplasia and preventing peripheral scar tissue hyperplasia while stopping bleeding, the curative effect of an operation is more remarkable, meanwhile, the operation time of the operation is saved, the operation is simple and rapid, and risks of the operation and environment pollution are reduced.

Description

technical field [0001] The invention relates to a multifunctional hemostatic cotton sheet, in particular to a mitomycin-containing hemostatic and anti-adhesion cotton sheet with functions of anti-scar, adhesion, postoperative infection and the like. Background technique [0002] Postoperative scar adhesion is the most common surgical complication, which seriously affects the function and appearance of patients. Its mechanism is the formation of local hematoma and fibroblast proliferation, and the formation of local hematoma is the main reason for the formation of scar adhesion. At present, the cotton sheet is recognized as the best compression hemostatic material in the operation. Scar hyperplasia and adhesion caused by surgical trauma and hematoma are often the reasons for poor curative effect or even failure of many surgical operations. A cotton pad that can not only accurately stop bleeding but also accurately prevent scar adhesion will bring new hope to surgical operatio...

Claims

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Application Information

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IPC IPC(8): A61L15/44A61K31/7024A61P7/04A61P17/02A61K31/407
Inventor 曹晓建戈应滨眭涛谢浩袁志兰
Owner 南京双健医疗科技有限公司
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