Application of a traditional Chinese medicine composition as preparation for treating oral ulcer
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A technology for oral ulcers and compositions, applied in the application field of traditional Chinese medicine compositions as preparations for the treatment of oral ulcers, can solve the problems of undisclosed traditional Chinese medicine compositions and the inability to obtain the treatment of oral ulcers and the like
Active Publication Date: 2018-01-19
GUANGZHOU BOJI MEDICINE SERVICES
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[0011] CN101940630A discloses a traditional Chinese medicine composition for treating gingivitis and a preparation method thereof, but the document does not disclose that the traditional Chinese medicine composition can be applied to the treatment of oral ulcers, and it cannot be concluded that it can be used for Mouth Ulcer Treatment
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[0019] The technical solution of the present invention will be further described below in combination with experiments.
[0020] 1. Materials
[0021] 1.1 Animals
[0022] SPF grade SD rats, male, 180-220g, provided by Zhejiang Experimental Animal Center, certificate number: SCXK (Zhejiang) 2014-0001; common grade guinea pigs, male, 250-300g, provided by Qinglong Mountain Animals, Jiangning District, Nanjing Provided by the breeding farm, certificate number: SCXK (Su) 20120008. The experimental animals were kept in an animal room at 22±2°C, free to eat and drink, and a 12h light / dark cycle was adopted indoors.
[0023] 1.2 Drugs and instruments
[0024]Ice lotus buccal tablets, ice lotus buccal tablets blank excipients, dissolved in double distilled water and set the experimental dose (smear administration, the dose is 50, 100, 200mg / kg three doses, respectively 1,2 of the daily dose of normal clinical administration. , and 4 times, or 5, 10 and 20 times of the clinical do...
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Abstract
The invention discloses the application of a traditional Chinese medicine composition as a preparation for treating oral ulcer. Animal experiments have shown that the traditional Chinese medicine composition disclosed in CN101940630A can reduce the degree of oral ulcers in guinea pigs and guinea pigs caused by phenol stimulation or electrocautery, reduce the content of hydroxyproline in the buccal tissue of model rats and guinea pigs, and promote ulcer healing. The effect is slightly stronger than the watermelon frost spray preparation of the same dose; the pathological examination has further confirmed its positive effect of inhibiting inflammatory cell infiltration and maintaining the integrity of epithelial tissue structure, and can effectively treat oral ulcers.
Description
technical field [0001] The invention relates to a new application of a traditional Chinese medicine composition, in particular to an application of a traditional Chinese medicine composition as a preparation for treating oral ulcers. Background technique [0002] Oral diseases are relatively common diseases, because people's unhealthy diet or bad living habits can cause oral diseases. Common oral ulcers, periodontal disease, pulp disease, wear, juvenile periodontitis, tongue disease, lip disease, dental caries, tetracycline teeth, simple periodontitis, oral candidiasis, etc. are common oral diseases, The incidence of these common oral diseases is very high, but they are often overlooked by people. [0003] Oral ulcers are the most common recurrent oral mucosal ulcerative lesions, mostly on the lips, cheeks, vestibular groove, tongue tip, tongue side edge, etc., with single or multiple pale yellow or off-white ulcerated spots, accompanied by pain or Pain when stimulated. T...
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