A preparation method of traditional Chinese medicine composition for treating nephropathy

Abstract

The invention relates to a preparation method for traditional Chinese medicine composition for treating nephropathy. Auxiliary rheum officinale is soaked and then subjected to treatment combining heating reflux water extraction and alaochol extraction, so that active ingredient dissolving-out amount of rheum officinale anthraquinones is effectively increased and the cold property of rheum officinale is improved when water-soluble substances of the rheum officinale are dissolved out, and the dosage proportion of the rheum officinale raw powder is greatly reduced, and the influence of the bitter and cold property of rheum officinale raw powder to drugs and human body is reduced, thereby improving the drug effect and reducing the cost. Water extract of raw material drugs of radix pseudostellariae and the like is refined and purified by adopting a macroporous resin adsorption method, active ingredients in the formula are highly enriched, and components of sugars, inorganic salts and the like in decoction are removed, so that the extract is small size, not prone to absorb water, and easily prepared into various drug forms, and heavy metals and a great deal of organic residues can be effectively removed, the phenomena of being thick, large and black of the conventional traditional Chinese medicine preparation are changed, the effects of removing rough products and obtaining fine products, and improving drug quality are achieved, and the preparation method is suitable for being popularized and applied in the traditional Chinese medicine field for treating nephropathy.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a preparation method of a traditional Chinese medicine composition for treating nephropathy. Background technique [0002] A number of studies have shown that rhubarb has a good curative effect on the treatment of kidney disease, it can inhibit the proliferation of mesangial cells and renal tubular epithelial cells, reduce compensatory hypertrophy, delay glomerular sclerosis, and improve hypercoagulation and hyperviscosity in patients with renal failure. state, improve renal blood flow, protect residual renal function, and reduce proteinuria. As a classic Chinese herbal medicine, rhubarb has a bitter and cold nature and taste, and returns to the spleen, stomach, large intestine, liver, and pericardium. Discomfort due to dysentery, damp-heat jaundice, vomiting of blood-heat, red eyes, swollen throat, abdominal pain, carbuncle and furuncle, blood stasis, amen...

AI Technical Summary

Problems solved by technology

Rhubarb is the king drug of traditional Chinese medicine composition for the treatment of kidney disease, and its main active ingredient rhubarb anthraquinone is an alcohol-soluble substance. At present, rhubarb is generally extracted by alcohol extraction, but rhubarb also contains total polysaccharides and flavonoids that can improve immunity. Water-soluble ingredients, while the extraction rate of the total active ingredients in the existing alcohol extraction method does not exceed 24%, so that the total polysaccharides, flavonoids and other water-soluble ingredients are lost

[0003] In addition, compound Chinese medicine is the main form of clinical treatment of traditional Chinese medicine. However, the problem of "thick, big and black" of compound Chinese medicine preparations seriously restricts its development.

However, the traditional water extraction and alcohol precipitation process is easy to cause the loss of active ingredients in the precipitation, the loss of active ingredients is too large during the removal of impurities, the production cycle is too long, and heavy metals and a large amount of organic residues cannot be removed.

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