Method and set for detecting alcohol metabolizing genes

A gene and genotype technology is applied in the field of detecting alcohol dehydrogenase and acetaldehyde dehydrogenase, and can solve the problems of complicated genotype polytype detection steps, difficulty in a large number of screening tests, and long time consumption.
CN104862382AInactive Publication Date: 2015-08-26CHI MEI MEDICAL CENT
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
CHI MEI MEDICAL CENT
Publication Date
2015-08-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to a method and a set for detecting alcohol metabolizing genes. The present invention provides a method and a reagent for detecting alcohol dehydrogenase (ADH1B) and aldehyde dehydrogenase (ALDH2). The method and the reagent have enough specifity and sensitivity, can save complicated steps for learning the technology, and can save time and manpower. The present invention further provides a method and a set for detecting an individual who has a high cancer risk after consuming alcohol.
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Description

technical field

[0001] The invention relates to the detection field of alcohol metabolism genes. Specifically, the present invention relates to methods and reagents for detecting alcohol dehydrogenase (ADH1B) and aldehyde dehydrogenase (ALDH2). Background technique

[0002] There have been many previous literatures in the field that support the polymorphism of alcohol dehydrogenase (alcohol dehydrogenase, ADH1B) gene and acetaldehyde dehydrogenase (aldehyde dehydrogenase, ALDH2) gene in cancer risk in alcohol consumers (especially Asian population) increased risk. Alcohol consumption in human individuals with ADH1B*1 / *1 or ALDH2*1 / *2 genotypes increases the risk of upper respiratory, gastrointestinal, and other cancers (Druesne-Pecollo N et al., Lancet Oncol. 2009; 10 (2):173-80; Yokoyama A et al., Keio J Med.2010; 59(4):115-30; Baan R et al., Lancet Oncol.2007Apr; 8(4):292-30 and Brooks PJ et al., PLoS Med. 2009 Mar 24;6(3):e50). The single nucleotide polymorphism (SNP)...

Claims

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