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Polyurethane derivatives simulating human fibrinolytic system and vascular endothelial system, preparation method and related product preparation method

A technology of polyurethane derivatives and fibrinolytic systems, applied in prosthesis, transportation and packaging, anticoagulation treatment, etc., can solve problems such as restricting development, uncontrollable binding amount, harsh reaction conditions of bioactive molecules, etc.

Inactive Publication Date: 2017-10-10
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These materials include cardiovascular system implants (heart valves, cardiovascular stents, catheters, vascular grafts, heart assist devices, etc.) and extracorporeal blood treatment instruments (hemodialysis equipment, extracorporeal circulation equipment), etc. Problems such as thrombus have always restricted the development of this type of material
The methods reported so far for the preparation of multifunctional anticoagulant surfaces have many shortcomings, such as harsh reaction conditions during the immobilization process of bioactive molecules, uncontrollable binding amount, etc.

Method used

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  • Polyurethane derivatives simulating human fibrinolytic system and vascular endothelial system, preparation method and related product preparation method
  • Polyurethane derivatives simulating human fibrinolytic system and vascular endothelial system, preparation method and related product preparation method
  • Polyurethane derivatives simulating human fibrinolytic system and vascular endothelial system, preparation method and related product preparation method

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Experimental program
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Effect test

preparation example Construction

[0069] (c) Preparation of lysine-modified cyclodextrin (β-CD-(Lys) 7 )

[0070] Alkynylated lysine and azidated β-cyclodextrin were subjected to click reaction, followed by deprotection treatment, and finally lysine-modified cyclodextrin was prepared.

[0071] The preparation method described in the above step (a) is one or both of the following:

[0072] First, the hydroxyl group at the sixth position of β-cyclodextrin is replaced by bromine (β-CD-(Br) 7 ), followed by azidation with sodium azide;

[0073] First, replace the hydroxyl group at the sixth position of β-cyclodextrin with iodine (β-CD-(I) 7 ), followed by azidation with sodium azide.

[0074] 4-oxo-4-(prop-2-yn-1-oxy)butanoic anhydride (4-oxo-4-(prop-2-yn-1-yloxy)butanoic anhydride described in step (b) above ) solution and a mixed solution of N(ε)-Boc-L-lysine tert-butyl ester hydrochloride and triethylamine, the solvents of which are dichloromethane.

[0075] The method used for the deprotection described ...

specific Embodiment

[0079](1) Polyurethane surface graft copolymerization P(HEMA-co-AdaMA)

[0080] Put 0.98 g of potassium thiocyanate and 40 mL of anhydrous acetonitrile in a 100 mL reaction flask and stir to dissolve. Slowly drop 0.82 mL of acryloyl chloride into the reaction flask, and stir the reaction at room temperature for 12 hours. The precipitate was removed by filtration, and the filtrate was directly used in the next reaction. Put 60 polyurethane diaphragms (thickness 0.5 mm) with a diameter of about 6 mm in a reaction flask containing 30 mL of the above filtrate, add 0.75 g of triethylamine to the reaction flask, stir and react at 65 °C for 2-12 hours, and then place The polyurethane diaphragm is taken out, washed with acetonitrile and dried to obtain a polyurethane diaphragm with carbon-carbon double bonds on the surface. Place 0.074 g of azobisisobutyronitrile, 5.78 g of HEMA, 0.13 g of AdaMA, 40 mL of isopropanol, and 60 pieces of polyurethane diaphragms with carbon-carbon doubl...

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Abstract

The invention provides a polyurethane derivative simulating the fibrinolytic system and vascular endothelial system of a human body, a preparation method and a preparation method of related products. The surface of the polyurethane material is covered with an inert polymer layer combined with two bioactive ligands. The above-mentioned hydrophilic inert polymer layer is P(HEMA‑co‑AdaMA). Covalent binding and host-guest interaction are modified step by step. The reaction conditions of the invention are mild and controllable, and the activity of the ligand can be preserved to a large extent. The inert polymer layer containing two bioactive molecules on the surface of the modified polyurethane provided by the present invention can not only effectively repel non-specific protein adsorption, but also has specificity because the polymer layer contains relatively rich ε-lysine Combined with plasminogen and its activator t-PA and capable of dissolving primary thrombus on the surface, the polymer layer contains REDV short peptide sequence, so that the modified surface can effectively promote the adhesion and proliferation of endothelial cells.

Description

technical field [0001] The invention relates to the field of biomedical functional polymer materials, in particular to a preparation method of a polyurethane material with good blood compatibility that simulates the fibrinolytic system and vascular endothelial system of a human body. Background technique [0002] Cardiovascular disease has become one of the biggest problems threatening human health. Since medical devices used for diagnosis and treatment of cardiovascular diseases inevitably come into contact with blood, blood-contact biomedical materials have very broad application prospects and huge market demands. These materials include cardiovascular system implants (heart valves, cardiovascular stents, catheters, vascular grafts, heart assist devices, etc.) and extracorporeal blood treatment instruments (hemodialysis equipment, extracorporeal circulation equipment), etc. Problems such as thrombus have always restricted the development of this type of material. Since t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L33/12A61L33/04A61L27/34A61L27/54A61L31/10A61L31/14C08F283/00C08F220/28
Inventor 陈红于谦占文俊陈高健
Owner SUZHOU UNIV
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