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Medical application of paecilomyces hepidl chen PH40 in resisting depression

A Paecilomyces bat moth, anti-depressant technology, applied in the direction of medical preparations containing active ingredients, fungi, pharmaceutical formulas, etc., can solve the problems of strong drug dependence, serious side effects of patients, etc., to achieve good prevention and The effect of the therapeutic effect

Active Publication Date: 2015-09-16
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antidepressant drugs are mostly steroidal inhibitors, which can cause serious side effects in patients while exerting significant drug effects, leading to strong drug dependence

Method used

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  • Medical application of paecilomyces hepidl chen PH40 in resisting depression
  • Medical application of paecilomyces hepidl chen PH40 in resisting depression
  • Medical application of paecilomyces hepidl chen PH40 in resisting depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Take 1L of Paecilomyces phaecillum strain PH40 fermentation broth, centrifuge at 5000r / min for 10min, collect the precipitate, freeze-dry in vacuum, pulverize with a high-speed pulverizer, pass through a 60-mesh sieve, and collect the bacterial powder, which is Paecilomyces phlegm strain PH40 bacterial powder 1

Embodiment 2

[0014] Take 1 L of Paecilomyces phaecillum strain PH40 fermentation broth, spray dry it, and collect the bacterial powder, which is Paecilomyces phalanx strain PH40 bacterial powder 2.

Embodiment 3

[0016] Take 1L of Paecilomyces phaecillum strain PH40 fermentation broth, centrifuge at 5000r / min for 10min, collect the precipitate, freeze-dry in vacuum, pulverize with a high-speed pulverizer, pass through a 60-mesh sieve, and collect the bacterial powder, which is Paecilomyces phlegm strain PH40 bacterial powder 3. Take the bacterial powder 3, add sodium bicarbonate, sodium carboxymethyl cellulose and other pharmaceutical excipients, and prepare the bacterial powder preparation 3 of Paecilomyces spp. strain PH40.

[0017] Following test shows the purposes of the present invention in antidepressant health products

[0018] 1. Materials and methods

[0019] 1.1 Test substance Example 1 Bacteria powder 1, Example 2 Bacteria powder 2, Example 3 Preparation 3.

[0020] 1.2 Experimental animals

[0021] 200 healthy SD male rats, weighing 180-220 g, were provided by the Experimental Animal Center of Jilin University. Randomly divided into 5 groups, 40 in each group.

[0022...

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PUM

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Abstract

The invention discloses a medical application of paecilomyces hepidl chen PH40 in resisting depression, and a remarkable medical effect is achieved. Paecilomyces hepidl chen PH40 bacterial powder is adopted as main components, and multiple kinds of pharmaceutic adjuvant materials are added, thereby preparing tablets, powder, capsules and oral preparations.

Description

technical field [0001] The invention discloses the medical application of the Paecilomyces hematalis strain PH40 in antidepressant, and belongs to the field of traditional Chinese medicine and health products. Background technique [0002] Depression is a common mental disorder that has become a leading cause of suicide and disability. In today's society, lifestyles are changing drastically, and people are under increasing pressure. Continuous exposure to chronic stress can easily lead to the occurrence and development of depression. Antidepressant drugs are mostly steroidal inhibitors, which can cause serious side effects and strong drug dependence in patients while exerting significant drug effects. In the past ten years, people have gradually focused on the antidepressant activity of natural products. Medicinal fungi have attracted more and more attention in recent years because of their high activity and low side effects. received extensive attention from researchers i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/068A61P25/24C12N1/14C12R1/79
Inventor 王迪王娟刘艳滕利荣刘洋程瑛琨权宇彤周毓麟逯家辉
Owner JILIN UNIV
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